Results 101 to 110 of about 11,628 (203)

Genome‐wide association study in 21,271 individuals identifies 9 novel loci associated with circulating CD34+ hematopoietic stem and progenitor cell levels

HemaSphere, Volume 10, Issue 7, July 2026.
Yuwen Xie, Antton Lamarca, Caterina Cafaro, Gudmar Thorleifsson, Ludvig Ekdahl, Daniela Torres Di Bello, Zain Ali, Yen La, Lilja Stefansdottir, Alex Antill, Maroulio Pertesi, Maria Laura Mahecha Escobar, Magnús K. Magnússon, Simon N. Stacey, Kari Stefansson, Ingileif Jonsdottir, Göran Karlsson, Thorunn Olafsdottir, Unnur Thorsteinsdottir, Aitzkoa Lopez de Lapuente Portilla, Björn Nilsson   +20 more
wiley   +1 more source

X‐Linked USP11 Drives Depression‐Like Behaviors by Stabilizing CK2α and Disrupting Mitochondrial Function

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that USP11 mediates depressive‐like behaviors and mitochondrial dysfunction in the prefrontal cortex. Mechanistically, USP11 directly binds to and deubiquitinates CK2α, thereby stabilizing its protein level and promoting mitochondrial impairment.
Yuqi Feng, Ningyuan Li, Lingfeng Zhang, Wei Wang, Hao Duan, Siqi Sun, Ruiling Li, Yuhui Zhang, Xinhua Song, Yingyue Zhang, Honghan Zhang, Zhaowen Nie, Hanchun Yan, Chao Wang, Zhongchun Liu   +14 more
wiley   +1 more source

OPG content of mock- or KLF2-transduced BOECs.

, 2012
(A) Immunofluorescence image showing co-localization of OPG (green) and VWF (red) in both mock- and KLF2-tranduced BOECs. Nuclei were stained using DAPI (blue).
Ruben Bierings (159083), Bieuwke S. Dragt (159089), Ellen L. van Agtmaal (159077), Jan Voorberg (159111), Mar Fernandez-Borja (159099), Anton J. G. Horrevoets (159105), Thomas A. Leyen (159093)   +6 more
core   +1 more source

Inflammatory Neovascularization and Vascular Remodeling Associated With Carotid Plaque Destabilization

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
A subset of endothelial cells in the AC region promoted neovascularization, while the PA region exhibited an increase in osteogenic VSMCs, contributing to vascular remodeling. Fibroblast‐mediated inflammatory regulation was predominantly enriched in the PA region, whereas the AC region harbored more macrophage subsets involved in lipid metabolism and ...
Xuejiao Dai, Jia Huang, Feihua Ni, Ruying Hu, Huiyan Zheng, Dan Wang, Jianqiao Zhang, Ting Sun   +7 more
wiley   +1 more source

Reduced average length of WPBs in KLF2-transduced BOECs.

, 2012
(A) Confocal microscopy analysis of WPBs in mock- and KLF2-transduced BOECs stained for VWF (red) and DAPI (blue). Scale bars: 10 µm. (B) Average amount of WPBs per cell in unstimulated and stimulated mock-transduced BOECs and KLF2-transduced BOECs ...
Ruben Bierings (159083), Bieuwke S. Dragt (159089), Ellen L. van Agtmaal (159077), Jan Voorberg (159111), Mar Fernandez-Borja (159099), Anton J. G. Horrevoets (159105), Thomas A. Leyen (159093)   +6 more
core   +1 more source

KLF2 Upregulates miR-483 to Modulate Endothelial Function [PDF]

, 2013
.KLF2, originally named lung kruppel-like factor (LKLF), is a zinc finger transcription factor that is heavily involved in vascular development. Recent studies have identified this shear stress responsive gene as a key regulator of endothelial function ...
Woo, Brian Justin
core  

MEFs lacking MED23 show altered Klf2 expression.

, 2014
A, Klf2 mRNA expression by qRT-PCR in Med23+/+ (WT) and Med23Δflox/Δflox (MED23 null) MEFs treated with Cre adenovirus, then three days later starved overnight and treated with serum for 1 hour.
Tomofusa Fukuyama (495453), Lawryn H. Kasper (495452), Paul K. Brindle (495455)   +2 more
core   +1 more source

UM171 suppresses breast cancer progression by inducing KLF2

Breast Cancer Research and Treatment
Abstract Purpose Breast cancer is the most frequent cancer in women with significant death rate. Morbidity is associated with drug resistance and metastasis. Development of novel drugs is unmet need.
Ran, Xiaojuan, Hu, Anling, Kuang, Yi, Wang, Chunlin, Liu, Wuling, Xiao, Xiao, Zacksenhaus, Eldad, Yu, Xiangdi, Ben-David, Yaacov   +8 more
openaire   +2 more sources

IL-6 and IL-8 content of KLF2-transduced BOECs.

, 2012
(A) Immunofluorescence image showing co-localization of IL-6 (green) and VWF (red) in IL-1β-treated KLF2- and mock-transduced BOECs. Nuclei were visualized with DAPI (blue). Scale bars: 10 µm.
Ruben Bierings (159083), Bieuwke S. Dragt (159089), Ellen L. van Agtmaal (159077), Jan Voorberg (159111), Mar Fernandez-Borja (159099), Anton J. G. Horrevoets (159105), Thomas A. Leyen (159093)   +6 more
core   +1 more source

The role of CCM proteins inβ1 Integrin-Klf2-Egfl7-mediated angiogenesis [PDF]

, 2015
Angiogenese ist entscheidend für die meisten physiologische Prozesse und viele pathologische Umstände. Dabei wird Angiogenese durch die Interaktion zwischen der extrazellulären Matrix (ECM) und endothelialen Zellen reguliert. Während der kardiovaskulären
Renz, Marc Andreas
core   +1 more source