Results 101 to 110 of about 12,659 (217)

KLF2/KLF4 Double Knock-out Mouse Embryos Show Cranial Bleeding with Endothelial Disruption of the Primary Head Vein [PDF]

, 2010
Krüppel-like factors (KLFs) are a family of 3 Cys2/His2 zinc finger transcription factors with a diverse set of roles in cellular differentiation, cell cycle regulation, tumor suppression, erythropoiesis, angiogenesis, and other processes.
Curtis, Benjamin
core   +1 more source

Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity

Glia, Volume 74, Issue 12, December 2026.
The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Reduced average length of WPBs in KLF2-transduced BOECs.

, 2012
(A) Confocal microscopy analysis of WPBs in mock- and KLF2-transduced BOECs stained for VWF (red) and DAPI (blue). Scale bars: 10 µm. (B) Average amount of WPBs per cell in unstimulated and stimulated mock-transduced BOECs and KLF2-transduced BOECs ...
Ruben Bierings (159083), Bieuwke S. Dragt (159089), Ellen L. van Agtmaal (159077), Jan Voorberg (159111), Mar Fernandez-Borja (159099), Anton J. G. Horrevoets (159105), Thomas A. Leyen (159093)   +6 more
core   +1 more source

Neointimal Hyperplasia and Restenosis: Epidemiology, Pathophysiology, Animal Models, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
The overall graphical diagram to summarize the pathological characteristics, pathogenesis, clinical manifestation, preclinical animal models, diagnostic methods, and intervention strategies for neointimal hyperplasia. Neointimal hyperplasia results from excessive proliferation and intimal migration of vascular smooth muscle cells (VSMCs) in the ...
Kaixu Wang, Daiyu Zhang, Yu Hu, Yixin Zhao, Xinling Wang, Long Jiang, Meixiu Jiang   +6 more
wiley   +1 more source

Levels of Klf2 and Klf4 in Klf5-KO ESCs.

, 2018
(A) Western blot analysis of WT and Klf5-KO ESCs. Western blot analysis was performed with antibodies against Klf2, Klf4, and β-actin. (B) Quantified signal intensity of Klf2 or Klf4 relative to β-actin.
Satoru Takahashi (32871), Ken Matsumoto (47689), Hitoshi Niwa (7709), Masafumi Muratani (4760067), Hyojung Jeon (2550952), Masatsugu Ema (200616), Tsuyoshi Waku (2550955), Takuya Azami (2550946)   +7 more
core   +1 more source

YAP Fuels Cerebral Cavernous Malformations by Regulating KLF4 Transcriptional Activity and Protein Stability

MedComm, Volume 7, Issue 11, November 2026.
Cerebral cavernous malformation (CCM) gene complex deficiency dual‐regulates YAP activity via a “dual‐pronged” mechanism: relieving LATS‐mediated inhibition to license YAP nuclear translocation, and promoting MAP3K3‐mediated YAP phosphorylation to stabilize YAP–KLF4 association.
Tingting Ye, Qi Zheng, Zonghao Hu, Haonan Fan, Zhongxing Sun, Xiya Li, Haomin Mo, Chengdong Chang, Yanhua Xu, Kai Wang, Dong Fang, Hai Song   +11 more
wiley   +1 more source

UM171 suppresses breast cancer progression by inducing KLF2

Breast Cancer Research and Treatment
Abstract Purpose Breast cancer is the most frequent cancer in women with significant death rate. Morbidity is associated with drug resistance and metastasis. Development of novel drugs is unmet need.
Ran, Xiaojuan, Hu, Anling, Kuang, Yi, Wang, Chunlin, Liu, Wuling, Xiao, Xiao, Zacksenhaus, Eldad, Yu, Xiangdi, Ben-David, Yaacov   +8 more
openaire   +2 more sources

The Role Of Klf2 In B Cell-Mediated Mucosal Immunity

, 2021
B cell therapies can help alleviate pathology caused by autoimmunity, indicating that B cells contribute to diseases such as type 1 diabetes, arthritis, and systemic lupus erythematosus (SLE).
Xhaho, Detjona
core   +1 more source

A crucial role of KLF2-regulated mitochondrial oxidative phosphorylation in maintaining the stemness of mesenchymal stem cells derived from bone marrow

Cell & Bioscience
Mesenchymal stem cells (MSCs) have many uses in tissue engineering and clinical applications. However, maintaining their stemness during in vitro expansion is challenging.
Zhiyuan Gong, Yangxi Cheng, Rui Deng, Ying Zhou, Dan Yu, Cheng Chen, Yingjie Wang, Huiyong Zhu   +7 more
doaj   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source