Results 131 to 140 of about 12,659 (217)

Delineation of Klf2 domains required for reprogramming EpiSCs to iPSCs.

open access: yes, 2016
(A) Western blot analysis of EpiSCs expressing epitope-tagged Klf2 and deletion (Δ) mutants. Closed arrowheads indicate epitope-tagged Klf2 proteins. (B) Fluorescence images of a reprogrammed Oct3/4-ΔPE-GFP EpiSC colony with a Klf2 deletion domain on day
Jun Yanagisawa (2550943)   +6 more
core   +1 more source

Krüppel-like Factor 2 (KLF2) in the Regulation of Lipid Accumulation, ROS, and Mitochondrial Functions During Foam Cell Formation in RAW264.7 Cells

open access: yesBiology
Foam cell formation, a hallmark of early atherosclerotic lesion development, is closely associated with mitochondrial dysfunction and excessive reactive oxygen species (ROS) production.
Md Sariful Islam Howlader   +4 more
doaj   +1 more source

KLF2 controls proliferation and apoptosis of human spermatogonial stem cells via targeting GJA1

open access: yesiScience
Summary: Human spermatogonial stem cells (SSCs) are essential for spermatogenesis and male fertility. However, molecular mechanisms regulating fate determinations of human SSCs remain elusive.
Wei Chen   +6 more
doaj   +1 more source

Resveratrol protects against uremic serum-induced endothelial cell injury by activating the FUS/KLF2/FBXW7 signaling pathway

open access: yesApplied Biological Chemistry
Background Chronic kidney disease causes endothelial cell dysfunction associated with uremia, which triggers a high risk of cardiovascular diseases. Furthermore, prolonged exposure of the vascular endothelium to uremic toxins could provoke endothelial ...
Danjun Wang   +3 more
doaj   +1 more source

Regulation of endothelial metabolism by laminar shear stress and flow-induced transcription factor KLF2

open access: yes, 2016
Flow hemodynamics regulates endothelial cell (EC) responses and laminar shear stress induces an atheroprotective and quiescent phenotype. The flow-responsive transcription factor KLF2 is a pivotal mediator of endothelial quiescence, but the precise ...
Doddaballapur, Anuradha
core  

KLF2 Upregulates miR-483 to Modulate Endothelial Function [PDF]

open access: yes, 2013
.KLF2, originally named lung kruppel-like factor (LKLF), is a zinc finger transcription factor that is heavily involved in vascular development. Recent studies have identified this shear stress responsive gene as a key regulator of endothelial function ...
Woo, Brian Justin
core  

KLF2 determines the susceptibility of T cells to immunoregulatory NK cells.

open access: yes
Abstract Natural killer (NK) cells suppress cellular and humoral immune responses via killing of T cells, resulting in diminished vaccine responses in mice and humans. Efforts to overcome this roadblock and achieve optimal immunity require an improved understanding of the molecular mediators facilitating NK cell-targeting of discrete subsets of
Stephen Waggoner   +8 more
openaire   +2 more sources

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