Results 11 to 20 of about 17,085 (238)
Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells [PDF]
Scientific Reports, 2017 The transcription factor Kruppel-like factor 2 (KLF2) is a critical anti-inflammatory and anti-atherogenic molecule in vascular endothelium. Enhancing KLF2 expression and activity improves endothelial function and prevents atherosclerosis.
Yanni Xu +6 more
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The FBW7-KLF2 axis regulates endothelial functions [PDF]
Cell Research, 2013 FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.
Yongchao, Zhao, Yi, Sun
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Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1 [PDF]
Molecular Immunology, 2008 We have shown previously that dipeptidyl peptidase 2 (DPP2) activity is essential for the survival of quiescent, but not activated, lymphocytes. The specific requirement of DPP2 activity for non-dividing cells is indicative of cell cycle specific regulation of this gene product.
Pradeep, Bista +3 more
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KLF2 regulates neutrophil migration by modulating CXCR1 and CXCR2 in asthma
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2020 Neutrophils are key inflammatory cells in the immunopathogenesis of asthma. Neutrophil migration can be initiated through activation of the CXCR1 and CXCR2 receptors by CXC chemokines, such as IL-8. Although transcription factor KLF2 has been found to maintain T cell migration patterns through repression of several chemokine receptors, whether KLF2 can
Zi Wang
exaly +3 more sources
FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation [PDF]
Cell Research, 2013 F-box and WD repeat domain-containing 7 (FBW7), the substrate-binding subunit of E3 ubiquitin ligase SCF(FBW7) (a complex of SKP1, cullin-1 and FBW7), plays important roles in various physiological and pathological processes. Although FBW7 is required for vascular development, its function in the endothelium remains to be investigated.
Rui, Wang +15 more
exaly +3 more sources
Redox Biology, 2020 To define the regulatory role of Kruppel-like factor 2 (KLF2) during osteoblast (OB) differentiation of dental pulp-derived stem cell (DPSC)s, herein, we show that the levels of KLF2 and autophagy-related molecules were significantly increased in ...
Jyotirindra Maity +2 more
exaly +3 more sources
A novel mechanism in regulating drug sensitivity, growth, and apoptosis of bortezomib-resistant multiple myeloma cells: the USP4/KLF2/HMGA2 cascade [PDF]
Journal of Orthopaedic Surgery and ResearchBackground Multiple myeloma (MM) is a malignant disorder originating from plasma cells. Bortezomib (BTZ) resistance has become a huge obstacle to MM treatment.
Ziyi Liu +7 more
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Mechanism of KLF2 in young mice with pneumonia induced by Streptococcus pneumoniae
Journal of Cardiothoracic SurgeryBackground Streptococcus pneumoniae (Spn) is a major causative agent of pneumonia, which can disseminate to the bloodstream and brain. Pneumonia remains a leading cause of death among children aged 1–59 months worldwide.
Xiaoshuang Li, Weihua Xu, Tao Jing
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Neutrophil extracellular traps in cardiac hypertrophy: a KLF2 perspective [PDF]
Journal of Clinical Investigation, 2022 About 6 million adults in the United States have heart failure, and the mortality five years after diagnosis remains high at approximately 50%. Incomplete understanding of disease pathogenesis limits therapeutics, especially in the case of heart failure with preserved ejection fraction, a condition commonly associated with cardiac hypertrophy ...
Dario F. Riascos-Bernal +1 more
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