Results 11 to 20 of about 12,659 (217)
The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy [PDF]
Biomedicines, 2022 Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS (endothelial nitric oxide synthase) expression, subsequent
Siarhei A. Dabravolski +5 more
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Klf2 Is an Essential Factor that Sustains Ground State Pluripotency [PDF]
Cell Stem Cell, 2014 The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiation Mek/Erk and Gsk3/Tcf3 pathways.
Yeo, Jia-Chi +14 more
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Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension [PDF]
Nature Communications, 2020 Abstract Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are compromised in PAH.
Hebah A. Sindi +17 more
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Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy [PDF]
Cells, 2022 Kruppel-like factor 2 (KLF2) regulates endothelial cell metabolism; endothelial dysfunction is associated with hypertension and is a predictor of atherosclerosis development and cardiovascular events.
Eunjin Bae +8 more
doaj +3 more sources
, 2018 Supplemental material, supplement_table-KLF2 for KLF2 Inhibits the Migration and Invasion of Prostate Cancer Cells by Downregulating MMP2 by Binshuai Wang, Mingyuan Liu, Yimeng Song, Changying Li, Shudong Zhang and Lulin Ma in American Journal of Men’s ...
Binshuai Wang +5 more
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Shear stress modulates endothelial KLF2 through activation of P2X4 [PDF]
Purinergic Signalling, 2015 Vascular endothelial cells that are in direct contact with blood flow are exposed to fluid shear stress and regulate vascular homeostasis. Studies report endothelial cells to release ATP in response to shear stress that in turn modulates cellular functions via P2 receptors with P2X4 mediating shear stress-induced calcium signaling and vasodilation.
Sathanoori, R +6 more
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KLF2 may suppress chicken adipogenesis by enhancing the GATA2 transcription
Scientific ReportsKruppel-like factor 2 (KLF2) acts as an essential modulator of adipogenesis; nevertheless, the exact molecular pathways governing its role remain uncharacterized. This investigation characterized the expression profile of KLF2 in human adipose tissue and
Tingting Zhang +6 more
doaj +2 more sources
Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins [PDF]
Developmental Cell, 2015 Mechanotransduction pathways are activated in response to biophysical stimuli during the development or homeostasis of organs and tissues. In zebrafish, the blood-flow-sensitive transcription factor Klf2a promotes VEGF-dependent angiogenesis. However, the means by which the Klf2a mechanotransduction pathway is regulated to prevent continuous ...
Renz, Marc +20 more
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Archives of Medical ScienceIntroduction Mesenchymal stem cells can develop into osteoblasts, making them a promising cell-based osteoporosis treatment. Despite their therapeutic potential, their molecular processes are little known.
Wenjie Ma, Chen Li
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KLF2 IS REQUIRED FOR NORMAL MOUSE CARDIOVASCULAR DEVELOPMENT [PDF]
, 2013 VCU Theses and ...
Chiplunkar, Aditi Raghunath
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