Results 11 to 20 of about 11,628 (203)
The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy [PDF]
Biomedicines, 2022 Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS (endothelial nitric oxide synthase) expression, subsequent
Siarhei A. Dabravolski +5 more
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Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy [PDF]
Cells, 2022 Kruppel-like factor 2 (KLF2) regulates endothelial cell metabolism; endothelial dysfunction is associated with hypertension and is a predictor of atherosclerosis development and cardiovascular events.
Eunjin Bae +8 more
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Klf2 Is an Essential Factor that Sustains Ground State Pluripotency [PDF]
Cell Stem Cell, 2014 The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiation Mek/Erk and Gsk3/Tcf3 pathways.
Yeo, Jia-Chi +14 more
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Scientific Reports, 2017 The transcription factor Kruppel-like factor 2 (KLF2) is a critical anti-inflammatory and anti-atherogenic molecule in vascular endothelium. Enhancing KLF2 expression and activity improves endothelial function and prevents atherosclerosis.
Yanni Xu +6 more
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Transcriptional regulation of endothelial KLF2 in vascular development
, 2022 The development of a functional vascular system is critically dependent on shear stress, a hemodynamic force exerted onto the vascular endothelium by flowing blood. Krüppel-like factor 2 (KLF2) is the central transcriptional regulator of the endothelial shear stress response, yet the mechanisms by which shear stress signalling controls KLF2 expression ...
Fleisinger, Lucija
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The impact of KLF2 modulation on the transcriptional program and function of CD8 T cells.
PLoS ONE, 2013 Krüppel-like factor 2 (KLF2) is a transcription factor that is highly expressed in quiescent T lymphocytes and downregulated in effector T cells. We now show that antigen receptor engagement downregulates KLF2 expression in a graded response determined ...
Gavin C Preston +4 more
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Shear stress modulates endothelial KLF2 through activation of P2X4 [PDF]
Purinergic Signalling, 2015 Vascular endothelial cells that are in direct contact with blood flow are exposed to fluid shear stress and regulate vascular homeostasis. Studies report endothelial cells to release ATP in response to shear stress that in turn modulates cellular functions via P2 receptors with P2X4 mediating shear stress-induced calcium signaling and vasodilation.
Sathanoori, R +6 more
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Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension [PDF]
Nature Communications, 2020 Abstract Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are compromised in PAH.
Hebah A. Sindi +17 more
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, 2018 Supplemental material, supplement_table-KLF2 for KLF2 Inhibits the Migration and Invasion of Prostate Cancer Cells by Downregulating MMP2 by Binshuai Wang, Mingyuan Liu, Yimeng Song, Changying Li, Shudong Zhang and Lulin Ma in American Journal of Men’s ...
Binshuai Wang +5 more
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Archives of Medical ScienceIntroduction Mesenchymal stem cells can develop into osteoblasts, making them a promising cell-based osteoporosis treatment. Despite their therapeutic potential, their molecular processes are little known.
Wenjie Ma, Chen Li
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