Molecular basis for modulation of the p53 target selectivity by KLF4 [PDF]
, 2012 The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo ...
Brandt, Tobias +4 more
core +23 more sources
Krüppel-like factor 4 transcriptionally regulates TGF-β1 and contributes to cardiac myofibroblast differentiation. [PDF]
PLoS ONE, 2013 Angiotensin II (Ang II) plays a major role in the pathogenesis of cardiac fibrosis in hypertension. It is known that Ang II induces TGF-β1 expression.
Yi Zhang +5 more
doaj +1 more source
Krüppel-like factor 2: a central regulator of B cell differentiation and plasma cell homing
Frontiers in Immunology, 2023 The development of B cells, their activation and terminal differentiation into antibody-producing plasma cells are characterized by alternating phases of proliferation and quiescence that are controlled by complex transcriptional networks.
Jens Wittner, Wolfgang Schuh
doaj +1 more source
Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease [PDF]
, 2016 BACKGROUND: Small airway remodeling is an important cause of the airflow limitation in chronic obstructive pulmonary disease (COPD). A large population of patients with COPD also have pulmonary hypertension.
Abe, K +14 more
core +4 more sources
PLoS ONE, 2021 Genes from the Grainyhead-like (GRHL) family code for transcription factors necessary for the development and maintenance of various epithelia. These genes are also very important in the development of many types of cancer. However, little is known about
Grzegorz Kotarba +4 more
doaj +1 more source
Technology in Cancer Research & Treatment, 2020 Cancer stem cells, a special subgroup of cancer cells, have self-renewal capabilities and multidirectional potential, which may be reprogrammed from the dedifferentiation of cancer cells, contributing to the failure of clinical treatments.
Mei Chen BSc +4 more
doaj +1 more source
Krüppel-like transcription factors and control of pluripotency
BMC Biology, 2010 Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant ...
Bourillot Pierre-Yves, Savatier Pierre
doaj +1 more source
Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]
, 2013 Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op +4 more
core +3 more sources
Erythroid Kruppel-like factor directly activates the basic Kruppel-like factor gene in erythroid cells [PDF]
, 2007 The Sp/Kriippel-like factor (Sp/KIf) family is comprised of around 25 zinc finger transcription factors that recognize CACCC boxes and GC-rich elements.
Crossley, Merlin +6 more
core +1 more source
Acute myeloid leukemia and transcription factors: role of erythroid Krüppel-like factor (EKLF)
Cancer Cell International, 2012 We have investigated the role of erythroid transcription factors mRNA expression in patients with acute myeloid leukemia (AML) in the context of cytogenetic and other prognostic molecular markers, such as FMS-like Tyrosine Kinase 3 (FLT3), Nucleophosmin ...
Ayala Rosa +2 more
doaj +1 more source