Results 11 to 20 of about 10,149 (182)

Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization [PDF]

Journal of Biological Chemistry, 2014
Accumulating evidence supports the importance of macrophage plasticity in a broad spectrum of biological processes operative in health and disease. A major locus of control regulating macrophage polarization is at the transcriptional level, and several major pathways have been elucidated in recent years.
Dipali, Date, Riku, Das, Goutham, Narla, Daniel I, Simon, Mukesh K, Jain, Ganapati H, Mahabeleshwar   +5 more
openaire   +2 more sources

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

The Kruppel‐like transcription factor KLF13 is a novel regulator of heart development [PDF]

The EMBO Journal, 2006
In humans, congenital heart defects occur in 1-2% of live birth, but the molecular mechanisms and causative genes remain unidentified in the majority of cases. We have uncovered a novel transcription pathway important for heart morphogenesis. We report that KLF13, a member of the Krüppel-like family of zinc-finger proteins, is expressed predominantly ...
Nemer, Georges, Horb, Marko E., Nemer, Mona, Nadeau, Mathieu, Lefebvre, Chantal, Lavallée, Geneviève, Andelfinger, Gregor   +6 more
openaire   +3 more sources

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis [PDF]

Journal of Clinical Investigation, 2015
Mitochondrial homeostasis is critical for tissue health, and mitochondrial dysfunction contributes to numerous diseases, including heart failure. Here, we have shown that the transcription factor Kruppel-like factor 4 (KLF4) governs mitochondrial biogenesis, metabolic function, dynamics, and autophagic clearance.
Xudong, Liao, Rongli, Zhang, Yuan, Lu, Domenick A, Prosdocimo, Panjamaporn, Sangwung, Lilei, Zhang, Guangjin, Zhou, Puneet, Anand, Ling, Lai, Teresa C, Leone, Hisashi, Fujioka, Fang, Ye, Mariana G, Rosca, Charles L, Hoppel, P Christian, Schulze, E Dale, Abel, Jonathan S, Stamler, Daniel P, Kelly, Mukesh K, Jain   +18 more
openaire   +2 more sources

Cell-specific Transcription of Leukotriene C4Synthase Involves a Kruppel-like Transcription Factor and Sp1 [PDF]

Journal of Biological Chemistry, 2000
Leukotriene C(4) synthase (LTC(4)S) is responsible for the biosynthesis of cysteinyl leukotrienes that participate in allergic and asthmatic inflammation. We analyzed 2.1 kilobases of the 5'-flanking region of the human LTC(4)S gene, which contains three DNase I hypersensitivity sites, for its transcriptional activity when fused to a promoterless and ...
J L, Zhao, K F, Austen, B K, Lam
openaire   +2 more sources

Lung Kruppel-like Factor, a Zinc Finger Transcription Factor, Is Essential for Normal Lung Development [PDF]

Journal of Biological Chemistry, 1999
Lung Kruppel-like factor (LKLF) is a member of the Kruppel-like factor family of transcription factors and is highly expressed in lung with limited distribution in other tissues. Mice lacking LKLF due to inactivation of LKLF by gene targeting die in utero at midgestation around day 12.5 due to severe hemorrhage, making it difficult to study the role of
M A, Wani, S E, Wert, J B, Lingrel
openaire   +2 more sources

Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages [PDF]

Journal of Biological Chemistry, 2004
Transcription of interleukin (IL)-12 p40 in myeloid cells is attributed to the recruitment of multiple activated transcription factors such as nuclear factor kappaB (NFkappaB), CCAAT enhancer-binding protein beta, ets-2, PU.1, and so forth. We now provide the first description of the human erythroid Kruppel-like factor (EKLF) in human primary ...
Qi, Luo, Xiaojing, Ma, Sharon M, Wahl, James J, Bieker, Merlin, Crossley, Luis J, Montaner   +5 more
openaire   +2 more sources

Prognostic value and immunological role of Kruppel-like transcription factor 9 gene in pan-carcinoma

Medicine, 2022
Objective: To investigate the correlation between the expression of Kruppel-like transcription factor 9 (KLF9) and the prognostic value of tumors as well as its relationship with tumor immune invasion. Methods: A series of bioinformatics methods were used to analyze the relationship
Weichao Cai, Yecheng Li, Weihong Cao
openaire   +2 more sources

Kruppel-Like Factor 2 Is a Transcriptional Regulator of Chronic and Acute Inflammation

The American Journal of Pathology, 2013
Although myeloid cell activation is requisite for an optimal innate immune response, this process must be tightly controlled to prevent collateral host tissue damage. Kruppel-like factor 2 (KLF2) is a potent regulator of myeloid cell proinflammatory activation.
Nayak, Lalitha, Goduni, Lediana, Takami, Yoichi, Sharma, Nikunj, Kapil, Parul, Jain, Mukesh K., Mahabeleshwar, Ganapati H.   +6 more
openaire   +2 more sources

Transcriptional repression of Kruppel like factor‐2 by the adaptor protein p66shc

The FASEB Journal, 2009
ABSTRACT The adaptor protein p66shc promotes cellular oxidative stress and apoptosis. Here, we demonstrate a novel mechanistic relationship between p66shc and the kruppel like factor‐2 (KLF2) transcription factor and show that this relationship has biological relevance to p66shc‐regulated cellular oxidant level ...
Ajay, Kumar, Timothy A, Hoffman, Jeremy, Dericco, Asma, Naqvi, Mukesh K, Jain, Kaikobad, Irani   +5 more
openaire   +3 more sources