Results 1 to 10 of about 54,134 (244)

Mechanism of KLF4 Inhibition of epithelial-mesenchymal transition in gastric cancer cells [PDF]

Open Life Sciences
This study investigates the mechanism by which Krüppel-like Factor 4 (KLF4) suppresses epithelial-mesenchymal transition (EMT) in gastric cancer cells.
Fu Yue, Lu Ze, Liu Xia, Li Chunming
doaj   +2 more sources

New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy

EMBO Molecular Medicine, 2020
KLF4 plays a critical role in determining cell fate responding to various stresses or oncogenic signaling. Here, we demonstrated that KLF4 is tightly regulated by poly(ADP‐ribosyl)ation (PARylation).
Zhuan Zhou, Rui Zhu, Aiping Luo
exaly   +2 more sources

Integrative Mendelian randomization and experimental validation prioritize KLF4 in the gut microbiota–pyroptosis–barrier axis of ulcerative colitis [PDF]

Frontiers in Immunology
BackgroundUlcerative colitis (UC) arises from complex crosstalk between gut microbiota, epithelial barrier integrity, and inflammatory cell death, yet causal mediators along this axis remain poorly defined.
Wenya Zhu, Xiaoxu Jin, Xiaoxu Jin, Xiaofeng Guo, Xin Gao   +4 more
doaj   +2 more sources

TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma [PDF]

Cell & Bioscience
Background Loss of tumor suppressor Krüpple-like factor 4 (KLF4) expression in hepatocellular carcinoma (HCC) is crucial for aggressive tumor progression and poor patient prognosis.
Zeping Chen, Senlin Zhao, Desheng Chen, Yichao Lou, Hanhao Lu, Qihang Yao, Jie Lu, Hongcheng Sun   +7 more
doaj   +2 more sources

Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment [PDF]

Cancer Medicine
Objective Krüppel‐like factor 4 (KLF4) is a zinc finger transcription factor that plays context‐dependent roles in cancer. It functions as either a tumor suppressor or an oncogene depending on tumor type and cellular context.
Min Tang, Binle Tian, Jingyi Zhou, Di Ma, Rongze Sun, Qi Li   +5 more
doaj   +2 more sources

Mechanism of miR-206 in Regulating KLF4 and Affecting Th17 Cell Differentiation in Neutrophil Asthma Inflammation [PDF]

Journal of Asthma and Allergy
Liting Feng, Yingna Li, Lulu Zhang, Yanqing Xing, Rujie Huo, Erjing Cheng, Xinrui Tian Department of Gerontology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Xinrui Tian, Department of ...
Feng L, Li Y, Zhang L, Xing Y, Huo R, Cheng E, Tian X   +6 more
doaj   +2 more sources

Helicobacter pylori infection leads to KLF4 inactivation in gastric cancer through a TET1‐mediated DNA methylation mechanism

Cancer Medicine, 2020
Krüppel‐like factor 4 (KLF4) has a tumor suppressor role in the progression of gastric cancer (GC), and inhibition or loss of KLF4 expression was identified in GC.
Rongrong Zhao, Zhengxia Liu, Yang Ou
exaly   +2 more sources

Evaluation of miR-107, DAPK1, and KLF4 Expression in Colorectal Tumors and Effect of Oxaliplatin and 5-FU on their Levels in Colorectal Cancer Cell Lines [PDF]

Middle East Journal of Cancer, 2021
Background: In recent years, the role of micro-RNAs in the cancer pathophysiology has attracted a great deal of scientific attention. MiRNAs regulate a variety of cellular functions, such as apoptosis, differentiation and migration by targeting oncogenic
Sahar Safaei, Dariush Shanehbandi, Venus Zafari, Elham Eghbali, Mahsa Sadeghzadeh, Haniye Mohammad Reza Khani, Amin Sadrazar, Masood Faghihdinevari, Masoud Shirmohamadi   +8 more
doaj   +1 more source

Role and Possible Mechanism of LncRNA-MEG3 and KLF4 in Carcinogenesis and Progression of Nasopharyngeal Carcinoma

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the role of LncRNAs-MEG3 in the carcinogenesis and progression of nasopharyngeal carcinoma (NPC) and the possible molecular mechanism. Methods qRT-PCR was used to detect the content of MEG3 and miR-543 in NPC cells.
NING Jiayu, BAO Weiijing, ZHOU Sujuan, WEI Rifu, ZHU Zhongshou   +4 more
doaj   +1 more source

KLF4 targets RAB26 and decreases 5-FU resistance through inhibiting autophagy in colon cancer

Cancer Biology & Therapy, 2023
Background Accumulating studies demonstrated that resistance of colon cancer (CC) to 5-fluorouracil (5-FU) contributes to adverse prognosis. We investigated how Kruppel-like factor 4 (KLF4) affected 5-FU resistance and autophagy in CC cells. Methods KLF4
Yu Zheng, Jiansheng Wu, Hong Chen, Dajia Lin, Hongyuan Chen, Junyin Zheng, Haoyun Xia, Liangxiang Huang, Changqing Zeng   +8 more
doaj   +1 more source