DUB3/KLF4 combats tumor growth and chemoresistance in hepatocellular carcinoma
Cell Death Discovery, 2022 This study aimed to investigate the role of deubiquitinating enzyme 3 (DUB3) in the regulation of Krüppel-like factor 4 (KLF4) expression in hepatocellular carcinoma (HCC).
Xuebing Jia +16 more
doaj +1 more source
MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs [PDF]
, 2016 Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers.
Alfano, Vincenzo +13 more
core +4 more sources
Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. [PDF]
, 2016 Great progress has been made regarding the capabilities to modify somatic cell fate ever since the technology for generation of induced pluripotent stem cells (iPSCs) was discovered in 2006.
Biswas, Sangita +3 more
core +2 more sources
Co-expression networks in generation of induced pluripotent stem cells. [PDF]
, 2016 We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni +6 more
core +2 more sources
KLF4 transactivates TRIM29 expression and modulates keratin network
Biochemistry and Biophysics Reports, 2021 The Krüppel-like factor 4 (KLF4) is well known to be a conserved zinc-containing transcription factor that participates in diverse biological processes such as cell proliferation and differentiation. In this study, we found KLF4 can bind specific site in
Runqing Huang, Yang Fu, Yanhong Deng
doaj +1 more source
KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency
Stem Cell Reports, 2018 Summary: Cooperative action of a transcription factor complex containing OCT4, SOX2, NANOG, and KLF4 maintains the naive pluripotent state; however, less is known about the mechanisms that disrupt this complex, initiating exit from pluripotency.
Navroop K. Dhaliwal +4 more
doaj +1 more source
Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development. [PDF]
PLoS ONE, 2015 Kruppel-like factor 4 (Klf4) is a transcription factor that regulates many important cellular processes in stem cell biology, cancer, and development. We used histological and molecular methods to study the expression of Klf4 in embryonic development of ...
Peter Zhang +4 more
doaj +1 more source
KLF4 is a novel regulator of the constitutively expressed HSP90 [PDF]
Cell Stress and Chaperones, 2010 Krüppel-like factor 4 (KLF4) is a zinc finger-containing transcription factor with diverse regulatory functions in cell growth, proliferation, and differentiation. But little is known about the regulation of KLF4 on the expression of HSP90 (HSP84 and HSP86).
Ying, Liu +5 more
openaire +2 more sources
Journal of Inflammation Research, 2021 Zhenjun Xu,1,* Kai Zhong,2,* Guanjun Guo,1,* Can Xu,1 Zhizhao Song,1 Dongjin Wang,1 Jun Pan1 1Department of Thoracic and Cardiovascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School ...
Xu Z +6 more
doaj
Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. [PDF]
PLoS ONE, 2012 Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine.
Tianxin Yu +7 more
doaj +1 more source