Results 51 to 60 of about 54,134 (244)

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis. [PDF]

, 2018
OBJECTIVE: Cigarette smoke exposure (CSE) is a risk factor for cerebral aneurysm (CA) formation, but the molecular mechanisms are unclear. Although CSE is known to contribute to excess reactive oxygen species generation, the role of oxidative stress on ...
Ali, Muhammad S., Chalouhi, Nohra, Ding, Dale, Dumont, Aaron S., Hare, Joshua M., Hasan, David M., Jabbour, Pascal, Martinez Lege, Alejandra, Owens, Gary K, Pascale, Crissey L., Starke, Robert M., Thompson, John W., Toborek, Michal   +12 more
core   +2 more sources

Cooperative Transcriptional Activation by Klf4, Meis2, and Pbx1 [PDF]

Molecular and Cellular Biology, 2011
The Kruppel-like factor Klf4 is implicated in tumorigenesis and maintaining stem cell pluripotency, and Klf4 can both activate and repress gene expression. We show that the Pbx1 and Meis2 homeodomain proteins interact with Klf4 and can be recruited to DNA elements comprising a Klf4 site or GC box, with adjacent Meis and Pbx sites.
Glen A, Bjerke, Cathy, Hyman-Walsh, David, Wotton   +2 more
openaire   +2 more sources

Structural basis for Klf4 recognition of methylated DNA [PDF]

Nucleic Acids Research, 2014
Transcription factor Krüppel-like factor 4 (Klf4), one of the factors directing cellular reprogramming, recognizes the CpG dinucleotide (whether methylated or unmodified) within a specific G/C-rich sequence. The binding affinity of the mouse Klf4 DNA-binding domain for methylated DNA is only slightly stronger than that for an unmodified oligonucleotide.
Liu, Yiwei, Olanrewaju, Yusuf Olatunde, Zheng, Yu, Hashimoto, Hideharu, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong   +6 more
openaire   +2 more sources

Melatonin selectively influences the transcription of pluripotency and differentiation markers in human non-cancer cells

Biotechnology & Biotechnological Equipment, 2019
Melatonin (MEL) may influence the efficiency of reprogramming both by somatic cell nuclear transfer and by direct induction of pluripotent stem cells (iPSC) through a yet unidentified mechanism. Transcription factors linked to cell reprogramming and cell
Georgi Nikolaev Georgiev, Elena Marinova, Rossitza Konakchieva, Plamen Todorov   +3 more
doaj   +1 more source

Krüppel-Like Factor 4 Inhibits Pancreatic Cancer Epithelial-to-Mesenchymal Transition and Metastasis by Down-Regulating Caveolin-1 Expression

Cellular Physiology and Biochemistry, 2018
Background/Aims: Krüppel-like factor 4 (KLF4), a member of the KLF family of zinc finger transcription factors, has been identified as a tumor suppressor gene in a variety of tumors.
Zhonglin Zhu, Zhilong Yu, Jianfeng Wang, Lisheng Zhou, Jing Zhang, Bin Yao, Jin Dou, Zhengjun Qiu, Chen Huang   +8 more
doaj   +1 more source

KLF4 suppresses the proliferation and metastasis of NSCLC cells via inhibition of MSI2 and regulation of the JAK/STAT3 signaling pathway

Translational Oncology, 2022
Background: Non-small cell lung cancer (NSCLC) remains an aggresive tumor with poor survival rates. Krüppel-like factor 4 (KLF4) is known to be involved in progression of NSCLC; however, the detailed mechanism by which KLF4 regulates the progression of ...
Di-Di Luo, Feng Zhao
doaj   +1 more source

Identification of Candidate Klf4 Target Genes Reveals the Molecular Basis of the Diverse Regulatory Roles of Klf4 in the Mouse Cornea [PDF]

Investigative Opthalmology & Visual Science, 2008
Krüppel-like factor 4 (Klf4) plays a crucial role in the development and maintenance of the mouse cornea. In the current study, wild-type (WT) and Klf4-conditional null (Klf4CN) corneal gene expression patterns were examined, to gain understanding of the molecular basis of the Klf4CN corneal phenotype.Expression of more than 22,000 genes in 10 WT and ...
Shivalingappa K, Swamynathan, Janine, Davis, Joram, Piatigorsky   +2 more
openaire   +2 more sources

Expression of transcription factors KLF2 and KLF4 is induced by the mammalian Golgi stress response

Cell Structure and Function
The Golgi stress response is a homeostatic mechanism that augments Golgi function when Golgi function becomes insufficient (Golgi stress). Glycosylation of the core proteins of proteoglycans is one of the important functions of the Golgi.
Kanae Sasaki, Reishi Tanaka, Iona Miyake, Miyu Sakamoto, Ryuya Tanaka, Azusa Tanaka, Misaki Terami, Ryota Komori, Mai Taniguchi, Sadao Wakabayashi, Hajime Tajima Sakurai, Hiderou Yoshida   +11 more
doaj   +1 more source

Attenuation of krüppel-like factor 4 facilitates carcinogenesis by inducing g1/s phase arrest in clear cell renal cell carcinoma. [PDF]

PLoS ONE, 2013
Krüppel-like factor 4 (KLF4) is a transcription factor with diverse functions in various cancer types; however, the function of KLF4 in clear cell renal cell carcinoma (ccRCC) carcinogenesis remains unknown.
Erlin Song, Xin Ma, Hongzhao Li, Peng Zhang, Dong Ni, Weihao Chen, Yu Gao, Yang Fan, Haigang Pang, Taoping Shi, Qiang Ding, Baojun Wang, Yu Zhang, Xu Zhang   +13 more
doaj   +1 more source

Meningioma: current updates on genetics, classification, and mouse modeling

Upsala Journal of Medical Sciences
Meningiomas, the most common primary brain tumors in adults, are often benign and curable by surgical resection. However, a subset is of higher grade, shows aggressive growth behavior as well as brain invasion, and often recurs even after several rounds ...
Frank Szulzewsky, H. Nayanga Thirimanne, Eric C. Holland   +2 more
doaj   +1 more source