Results 11 to 20 of about 54,134 (244)
KLF4 transcription factor in tumorigenesis
Cell Death Discovery, 2023 AbstractKrüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of Krüppel-like transcriptional factor usually causes abnormal embryonic development and even embryonic death. KLF4 is a prominent member of this family, and embryonic deletion of KLF4 leads to alterations in skin permeability and postnatal death.
Zhihong He, Jie He, Keping Xie
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KLF4 Regulates Metabolic Homeostasis in Response to Stress [PDF]
Cells, 2021 Cancerous cells are detrimental to the human body and can be incredibly resilient against treatments because of the complexities of molecular carcinogenic pathways. In particular, cancer cells are able to sustain increased growth under metabolic stress due to phenomena like the Warburg effect.
Andrew Blum +6 more
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Transcriptional Regulation of Adipogenesis by KLF4 [PDF]
Cell Metabolism, 2008 While adipogenesis is known to be controlled by a complex network of transcription factors, less is known about the transcriptional cascade that initiates this process. We report here the characterization of Krüppel-like factor 4 (KLF4) as an essential early regulator of adipogenesis.
Birsoy, Kıvanç +2 more
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MiRrored Regulation of KLF2 and KLF4 [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2012 A healthy organism demands much from its endothelium; constance in homeostatic control of blood fluidity, vascular tone, interaction with circulating blood cells, maintenance of barrier functions, and, when appropriate, creation of new blood vessels. Breakdown in any of these functions, anywhere in the 60,000 miles of vessels in the human body, leads ...
Anne, Hamik, Mukesh K, Jain
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Endothelial KLF4: Crippling Vascular Injury? [PDF]
Journal of the American Heart Association, 2014 The health of the vascular endothelium is critical for normal vascular physiologic function, and dysfunction of the endothelium can lead to development of vascular disease, such as atherosclerosis and thrombosis.
Tugal, Derin +2 more
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Upregulation of the constitutively expressed HSC70 by KLF4 [PDF]
Cell Stress and Chaperones, 2008 Krüppel-like factor 4 (KLF4) is a transcription factor that is abundantly expressed in various organisms from bacteria to mammals. It has been demonstrated that KLF4 regulates the expression of a wide range of genes. Analysis of KLF4 target genes reveals its diverse regulatory functions in cell growth, proliferation, differentiation, embryogenesis, and
Ying, Liu +5 more
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Open Life Sciences, 2020 Accumulating evidence suggests that dysregulation of long non-coding RNAs is closely associated with various human diseases, including Parkinson’s disease (PD). However, the role of nuclear-enriched abundant transcript 1 (NEAT1) in the PD process remains
Liu Jiyao +6 more
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Regulation of EMT by KLF4 in Gastrointestinal Cancer [PDF]
Current Cancer Drug Targets, 2013 Gastrointestinal (GI) cancer is characterized by its aggressiveness, but the underlying mechanism is not fully understood. Studies reveal that epithelial to mesenchymal transition (EMT), which is regulated by a series of transcription factors and signaling pathways, is strongly associated with GI cancer cell proliferation, invasion and metastasis ...
Jiujie, Cui +3 more
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Induction of KLF4 in response to heat stress [PDF]
Cell Stress & Chaperones, 2006 Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor with diverse regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. However, little is known about the response of KLF4 to heat stress.
Ying, Liu +9 more
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The Partial Role of KLF4 and KLF5 in Gastrointestinal Tumors
Gastroenterology Research and Practice, 2021 Background. KLF4 and KLF5 are members of the KLF transcription factor family, which play an important role in many gastrointestinal tumors. To gain a deeper insight into its function and role, bioinformatics was used to analyze the function and role of KLF4 and KLF5 in gastrointestinal tumors. Methods. Data were collected from several online databases.
Jun-Chen Li +7 more
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