Cutting Edge: The Transcription Factor Kruppel-Like Factor 4 Regulates the Differentiation of Th17 Cells Independently of RORγt [PDF]
The Journal of Immunology, 2010 Abstract Th17 cells play a significant role in inflammatory and autoimmune responses. Although a number of molecular pathways that contribute to the lineage differentiation of T cells have been discovered, the mechanisms by which lineage commitment occurs are not fully understood.
Lori, Lebson +6 more
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Frontiers in Cell and Developmental Biology, 2019 A variety of cardiac transcription factors/cofactors, signaling pathways, and downstream structural genes integrate to form the regulatory hierarchies to ensure proper cardiogenesis in vertebrate.
Chang Xue +6 more
doaj +1 more source
Transcription Factors as Therapeutic Targets in Chronic Kidney Disease
Molecules, 2018 The growing number of patients with chronic kidney disease (CKD) is recognized as an emerging problem worldwide. Recent studies have indicated that deregulation of transcription factors is associated with the onset or progression of kidney disease ...
Akihito Hishikawa +2 more
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A systems biology analysis of brain microvascular endothelial cell lipotoxicity. [PDF]
, 2014 BackgroundNeurovascular inflammation is associated with a number of neurological diseases including vascular dementia and Alzheimer's disease, which are increasingly important causes of morbidity and mortality around the world.
Aung, Hnin H +3 more
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Luna, a Drosophila KLF6/KLF7, is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo. [PDF]
PLoS ONE, 2014 Krüppel like factors (KLFs) are conserved transcription factors that have been implicated in many developmental processes including differentiation, organ patterning, or regulation of stem cell pluripotency.
Ursula Weber +3 more
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MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs [PDF]
, 2016 Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers.
Alfano, Vincenzo +13 more
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Kruppel‐like transcription factor KLF8 regulates of early adipocyte differentiation
The FASEB Journal, 2012 KLF8 is a zinc‐finger transcription factor known to play an essential role in cell cycle and differentiation. However, its physiological roles and functions in 3T3‐L1 cells remain relatively unclear. In the present study, we showed that KLF8 acts as a key regulator controlling adipocyte differentiation.
Hyo Jung Kim +5 more
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Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis [PDF]
Proceedings of the National Academy of Sciences, 1998 Wound repair in the liver induces altered gene expression in stellate cells (resident mesenchymal cells) in a process known as “activation.” A zinc finger transcription factor cDNA, zf9 , was cloned from rat stellate cells activated in vivo .
V, Ratziu +7 more
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The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo [PDF]
, 2012 The CACCC-box binding protein erythroid Kruppel-like factor (EKLF/KLF1) is a master regulator that directs the expression of many important erythroid genes.
Borg J +22 more
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Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2 [PDF]
Cardiovascular Research, 2008 Statins have beneficial vascular effects beyond their cholesterol-lowering action. Since macrophages play a central role in atherogenesis, we characterized the effects of simvastatin on gene expression profile of human peripheral blood monocyte (HPBM)-macrophages.Gene expression profile was studied using Affymetrix gene chip analysis.
Tuomisto, Tiina T. +9 more
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