Results 51 to 60 of about 10,149 (182)

Functional Evolution of cis-Regulatory Modules at a Homeotic Gene in Drosophila [PDF]

, 2011
It is a long-held belief in evolutionary biology that the rate of molecular evolution for a given DNA sequence is inversely related to the level of functional constraint.
Allen, John M, Bae, Esther, Bender, Welcome W., Celniker, Susan E., Drewell, Robert A., Fisher, William W., Goetz, Sara E., Ho, Margaret C. W., Johnsen, Holly, Rau, Christoph, Schiller, Benjamin J., Shur, Andrey S., Tran, Diana A.   +12 more
core   +1 more source

Mechanisms of Pericyte‐Mediated Cancer Metastasis

Advanced Science, EarlyView.
Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley   +1 more source

Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer

Heliyon
Lung cancer still is one of the most common malignancy tumors in the world. However, the mechanisms of its occurrence and development have not been fully elucidated.
Yang Shi, Min Yao, Shuijie Shen, Li Wang, Dengfu Yao   +4 more
doaj   +1 more source

Direct targets of Klf5 transcription factor contribute to the maintenance of mouse embryonic stem cell undifferentiated state

BMC Biology, 2010
Background A growing body of evidence has shown that Krüppel-like transcription factors play a crucial role in maintaining embryonic stem cell (ESC) pluripotency and in governing ESC fate decisions. Krüppel-like factor 5 (Klf5) appears to play a critical
Aloia Luigi, Ciriello Simona, Passaro Fabiana, Tarantino Carolina, Cozzuto Luca, Parisi Silvia, Antonini Dario, De Simone Vincenzo, Pastore Lucio, Russo Tommaso   +9 more
doaj   +1 more source

Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells [PDF]

, 2012
It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells.
Alluin, J, Habib, N, Kasahara, N, Mintz, P, Rossi, J, Sun, G, Sætrom, P, Voutila, J   +7 more
core   +4 more sources

Interaction of PRP4 with Krüppel-Like Factor 13 Regulates CCL5 Transcription [PDF]

The Journal of Immunology, 2007
Abstract Activation of resting T lymphocytes initiates differentiation into mature effector cells over 3–7 days. The chemokine CCL5 (RANTES) and its major transcriptional regulator, Krüppel-like factor 13 (KLF13), are expressed late (3–5 days) after activation in T lymphocytes.
Boli, Huang, Yong-Tae, Ahn, Lisa, McPherson, Carol, Clayberger, Alan M, Krensky   +4 more
openaire   +2 more sources

Quantitative Analysis of Kruppel-Like Factor 5-Related Messenger RNA Transcripts in Ischemic Myocardium for Discrimination of Death Causes

Journal of Forensic Science and Medicine, 2022
Background: Accumulated studies have demonstrated that Kruppel-like factor 5 (KLF5), a transcription factor, plays an important role in regulating cell proliferation and tissue remodeling through the expression of its downstream genes.
Xingyu Ma, Yeming Li, Ya Xi, Liyang Su, Yuxing Tong, Chun Wang, Tianshui Yu, Dong Zhao   +7 more
openaire   +2 more sources

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation

Haematologica, 2014
The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis. They can partially compensate for each other during mouse development, and coordinately regulate numerous erythroid genes, including the β-like globins ...
Divya S. Vinjamur, Kristen J. Wade, Safa F. Mohamad, Jack L. Haar, Stephen T. Sawyer, Joyce A. Lloyd   +5 more
doaj   +1 more source

New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma

Acta Neuropathologica Communications, 2020
The catalytic activity of human Telomerase Reverse Transcriptase (TERT) compensates for the loss of telomere length, eroded during each cell cycle, to ensure a correct division of stem and germinal cells.
Tiziana Pierini, Carlotta Nardelli, Anair Graciela Lema Fernandez, Valentina Pierini, Fabrizia Pellanera, Valeria Nofrini, Paolo Gorello, Martina Moretti, Silvia Arniani, Giovanni Roti, Paolo Giovenali, Marco Lupattelli, Giulio Metro, Carmen Molica, Corrado Castrioto, Rodolfo Corinaldesi, Maria Elena Laurenti, Stefano Ascani, Cristina Mecucci, Roberta La Starza   +19 more
doaj   +1 more source