Results 71 to 80 of about 10,149 (182)
KLF4 Promotes Angiogenesis by Activating VEGF Signaling in Human Retinal Microvascular Endothelial Cells. [PDF]
PLoS ONE, 2015 The transcription factor Krüppel-like factor 4 (KLF4) has been implicated in regulating cell proliferation, migration and differentiation in a variety of human cells and is one of four factors required for the induction of pluripotent stem cell ...
Yinan Wang +6 more
doaj +1 more source
eLife, 2021 The mechanical challenge of attaching elastic tendons to stiff bones is solved by the formation of a unique transitional tissue. Here, we show that murine tendon-to-bone attachment cells are bi-fated, activating a mixture of chondrocyte and tenocyte ...
Shiri Kult +15 more
doaj +1 more source
KLF6 and STAT3 Co-Occupy Regulatory DNA and Functionally Synergize to Promote Axon Growth in CNS Neurons [PDF]
, 2018 The failure of axon regeneration in the CNS limits recovery from damage and disease. Members of the KLF family of transcription factors can exert both positive and negative effects on axon regeneration, but the underlying mechanisms are unclear.
Blackmore, Murray G. +7 more
core +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism
eLife, 2021 The mammalian circadian timing system and metabolism are highly interconnected, and disruption of this coupling is associated with negative health outcomes.
Anthony A Ruberto +8 more
doaj +1 more source
Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo [PDF]
, 2016 Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of ...
Berek, Jonathan S +5 more
core +2 more sources
Journal of Biological Chemistry, 1994 Erythroid Kruppel-like factor (EKLF) is an erythroid-specific transcription factor that binds a CACCC motif found in the human beta-globin gene promoter. We have studied the promoter of the EKLF gene and identified binding sites for the transcription factors GATA-1 and CCAAT-binding Protein 1 (CP1). We show that both types of binding sites are required
M, Crossley +3 more
openaire +2 more sources
Medicine Bulletin, EarlyView.ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang +10 more
wiley +1 more source
LifeThe kidneys contribute to the overall health of an organism by maintaining systemic homeostasis. This process involves various biological mechanisms, in which the Krüppel-like factors (KLFs), a family of transcription factors, are essential for ...
Itzel S. Salmon-Cabrales +10 more
doaj +1 more source
Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis
Scientific Reports, 2023 Krüppel-like transcription factors (Klfs), which are characterized by the three conserved C-terminal zinc fingers, are involved in various biological processes, such as haematopoiesis and angiogenesis. However, how the Klf family of transcription factors
Hiroaki Suzuki +4 more
doaj +1 more source