Results 91 to 100 of about 10,149 (182)
Selecting Optimal Combinations of Transcription Factors to Promote Axon Regeneration: Why Mechanisms Matter [PDF]
, 2016 Recovery from injuries to the central nervous system, including spinal cord injury, is constrained in part by the intrinsically low ability of many CNS neurons to mount an effective regenerative growth response.
Blackmore, Murray G. +1 more
core +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Mesenchymal Stromal Cells from Neonatal Tracheal Aspirates Demonstrate a Pattern of Lung-Specific Gene Expression [PDF]
, 2011 We have previously isolated mesenchymal stromal cells (MSCs) from the tracheal aspirates of premature neonates with respiratory distress. Although isolation of MSCs correlates with the development of bronchopulmonary dysplasia, the physiologic role of ...
Adam M. Goldsmith +12 more
core +1 more source
Regulation of Corneal Epithelial Barrier Function by Krüppel-like Transcription Factor 4 [PDF]
Investigative Opthalmology & Visual Science, 2011 Previously, the authors showed that Klf4-conditional null (Klf4CN) corneas display epithelial fragility. Here, they investigated the mechanism by which Klf4 regulates corneal epithelial barrier function.Klf4CN mice were generated by breeding Le-Cre with Klf4-LoxP mice. Fluorescein staining was used to test the corneal barrier function.
Sudha, Swamynathan +3 more
openaire +2 more sources
Allergy, EarlyView.We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen +5 more
wiley +1 more source
Stress Can Induce Bovine Alpha-Herpesvirus 1 (BoHV-1) Reactivation from Latency
VirusesBovine alpha-herpesvirus 1 (BoHV-1) is a significant problem for the cattle industry, in part because the virus establishes latency, and stressful stimuli increase the incidence of reactivation from latency.
Fouad El-Mayet, Clinton Jones
doaj +1 more source
Aberrant regulation of FBW7 in cancer [PDF]
, 2014 FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc.
Liu, Yueyong +4 more
core +1 more source
British Journal of Haematology, EarlyView.Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo +13 more
wiley +1 more source
The reprogramming factor KLF4 in normal and malignant blood cells
Frontiers in ImmunologyThe Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger transcription factor that regulates cellular processes in stem cells, epithelial cells, and immune blood cells by controlling gene expression through genetic, epigenetic, and ...
H. Daniel Lacorazza
doaj +1 more source
Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration
eLife, 2017 Altered DNA methylation status is associated with human diseases and cancer; however, the underlying molecular mechanisms remain elusive. We previously identified many human transcription factors, including Krüppel-like factor 4 (KLF4), as sequence ...
Jun Wan +11 more
doaj +1 more source