Results 101 to 110 of about 10,149 (182)

Histone-Binding of DPF2 Mediates Its Repressive Role in Myeloid Differentiation [PDF]

, 2017
Double plant homeodomain finger 2 (DPF2) is a highly evolutionarily conserved member of the d4 protein family that is ubiquitously expressed in human tissues and was recently shown to inhibit the myeloid differentiation of hematopoietic stem/progenitor ...
Davenport, Andrew M., Greenblatt, Sarah M., Hoelz, André, Huber, Ferdinand M., Martinez, Concepcion, Nimer, Stephen D., Vu, Ly P., Xu, Ye   +7 more
core   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis [PDF]

, 2011
Background Nerve growth factor (NGF) is a potent growth factor that plays a key role in neuronal cell differentiation and may also play a role in hematopoietic differentiation.
Priyanka Dutta, Alexandra Koch, Bjoern Breyer, Heike Schneider, Oliver Dittrich-Breiholz, Michael Kracht, Teruko Tamura   +6 more
core   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response. [PDF]

, 2018
The major histocompatibility complex (MHC) is most closely associated with nasopharyngeal carcinoma (NPC), but the complexity of its genome structure has proven challenging for the discovery of causal MHC loci or genes.
Cheng, Zhi, Dong, Lei, Han, Ming-Yu, Huang, Zhong-Xi, Jiang, Tao, Li, Jin-Bang, Li, Xin, Li, Xin, Liu, Teng-Fei, Liu, Xiao, Long, Xiao-Bing, Lyu, Xiao-Ming, Qiu, Mo-Chang, Sun, Tao, Wang, Jia-Hong, Wang, Jian-Guo, Wang, Qian, Wang, Shuang, Wei, Gan-Guan, Yang, Xue-Xi, Yao, Kaitai, Zhang, Bo, Zhang, Long-Cheng, Zhao, Manli, Zheng, Hou-Feng, Zheng, Lu, Zhu, Xiao-Wei, Zuo, Xian-Bo   +27 more
core   +2 more sources

Krüppel-Like Factor 4 [PDF]

Circulation Research, 2008
See related article, pages 1548–1557 The transcriptional response to vascular injury. The vascular response to injury is a dynamic and multifactorial process involving several cell types. As part of the vascular response to injury, normally quiescent, contractile vascular smooth muscle cells (VSMCs) respond to inflammatory and growth factors by ...
openaire   +2 more sources

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

The involvement of krüppel-like transcription factor 2 in megakaryocytic differentiation induction by phorbol 12-myrestrat 13-acetate

Biomarker Research
Background Megakaryocytic differentiation is a complicated process regulated by a series of transcription factors in a context- and stage-dependent manner.
Zhen Wang, Zhongwen Liu, Pan Zhou, Xiaona Niu, Zhengdao Sun, Huan He, Zunmin Zhu   +6 more
doaj   +1 more source

Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice

eLife, 2016
Krüppel-like factor 5 (Klf5) is a zinc-finger transcription factor that controls various biological processes, including cell proliferation and differentiation.
Shinichiro Hayashi, Ichiro Manabe, Yumi Suzuki, Frédéric Relaix, Yumiko Oishi   +4 more
doaj   +1 more source

Transposable Elements, Inflammation, and Neurological Disease. [PDF]

, 2019
Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-
Macia, Angela, Muotri, Alysson R, Saleh, Aurian   +2 more
core