Results 121 to 130 of about 10,149 (182)

Krüppel-like factors in mitochondrial quality control

Frontiers in Physiology
Krüppel-like factors (KLFs) are a group of transcription factors characterized by conserved zinc finger domains in the C-terminus, which are critically involved in basic cellular processes, including growth, differentiation, apoptosis, and angiogenesis ...
M. Y. Zhang, H. Zhang, Y. M. Yao, D. W. Yang   +3 more
doaj   +1 more source

Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition [PDF]

, 2018
Vascular smooth muscle cells (VSMCs) are central players in carotid atherosclerosis plaque development. Although the precise mechanisms involved in plaque destabilization are not completely understood, it is known that VSMC proliferation and migration ...
Alloza Moral, Iraide, Elizagaray, Elena, Freijo, María del Mar, Goikuria Iriondo, Haize, Lorenzo, Ana, Sastre, María, Vandenbroeck, Koen, Vega Manrique, Reyes   +7 more
core   +3 more sources

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Glucose metabolic reprogramming is a central driver of immunosuppression in the tumour microenvironment, orchestrating immune dysfunction through multiple interconnected mechanisms. Glucose competition establishes a selective bioenergetic hierarchy that constrains antitumour immunity, whereas lactate accumulation and its reciprocal crosstalk with ...
Yang Wang, Yijun Lu, Jian Zhou, Xinrong Yang   +3 more
wiley   +1 more source

Ehf and Fezf2 regulate late medullary thymic epithelial cell and thymic tuft cell development

Frontiers in Immunology
Thymic epithelial cells are indispensable for T cell maturation and selection and the induction of central immune tolerance. The self-peptide repertoire expressed by medullary thymic epithelial cells is in part regulated by the transcriptional regulator ...
Sören Lammers, Victor Barrera, Philip Brennecke, Philip Brennecke, Corey Miller, Joon Yoon, Jared Balolong, Mark S. Anderson, Shannan Ho Sui, Lars M. Steinmetz, Lars M. Steinmetz, Lars M. Steinmetz, Ulrich H. von Andrian, Ulrich H. von Andrian, Kristin Rattay, Kristin Rattay   +15 more
doaj   +1 more source

Consolidating Clinical Insights and Uncovering Novel Regulatory Mechanisms of Exosomal MicroRNAs in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease: A Systematic Review and Bioinformatics Analysis

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Clinical studies identified 93 obesity‐associated and 24 NAFLD‐associated exosomal miRNAs, with let‐7b and miR‐335‐5p emerging as common nodes. Bioinformatics analysis revealed extensive overlap at the functional level, including 40,410 shared miRNA‐mRNA interactions and 42 common target genes. Several circulating exosomal miRNAs from obese individuals,
Qigui Mo, Amirreza Ghafourian, Masoomeh Hamdi, Arian Alidadipour, Mahdieh Soleimani, Maryam Davoudi, Xiaolei Miao, Reza Afrisham, Molood Bagherieh   +8 more
wiley   +1 more source

Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis [PDF]

, 2015
Induced pluripotent stem (iPS) cells can be generated from somatic cells by coexpression of four transcription factors: Sox2, Oct4, Klf4, and c-Myc.
Dai, Xiangpeng, Inuzuka, Hiroyuki, Lau, Alan W, Liu, Pengda, Liu, Yueyong   +4 more
core   +1 more source

Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 5, May 2026.
This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng, Yu‐Xuan Gao, Mei‐Xing Guo, Li‐Ting Wang, Xiao‐Wen Zheng, Yi‐Hao Liao, Ya Li, Jun‐Ping Zhu, Jia‐Ming Wei   +8 more
wiley   +1 more source

The hardwiring of development: Organization and function of genomic regulatory systems [PDF]

, 1997
The gene regulatory apparatus that directs development is encoded in the DNA, in the form of organized arrays of transcription factor target sites. Genes are regulated by interactions with multiple transcription factors and the target sites for the ...
Arnone, Maria I., Davidson, Eric H.
core  

Role of noncoding RNA in vascular remodelling [PDF]

, 2016
Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H., Bradshaw, Angela C., Deng, Lin   +2 more
core   +1 more source