Results 131 to 140 of about 10,149 (182)

Endothelial cell activation by antiphospholipid antibodies is modulated by Krüppel-like transcription factors

Blood, 2011
Abstract Antiphospholipid syndrome is characterized by thrombosis and/or recurrent pregnancy loss in the presence of antiphospholipid antibodies (APLAs). The majority of APLAs are directed against phospholipid-binding proteins, particularly β2-glycoprotein I (β2GPI).
Kristi L, Allen, Anne, Hamik, Mukesh K, Jain, Keith R, McCrae   +3 more
openaire   +3 more sources

Age‐Dependent Alterations of Chromosomal Passenger Complex Members During Implantation and Decidualization in the Mouse Uterus

Aging Cell, Volume 25, Issue 5, May 2026.
Aging in females reduces the number of implantation sites and leads to specific, compartment‐dependent changes in components of the chromosomal passenger complex (pIncenp, Aurora B, Survivin, Borealin) during mouse uterine implantation and decidualization.
Ezgi Golal, Cemre Nur Balci, Nuray Acar
wiley   +1 more source

KLF feedback loops in innate immunity

Frontiers in Immunology
The Krüppel-like factor (KLF) family of zinc finger transcription factors regulate the expression of genes involved in a wide range of cellular processes, including cell proliferation and differentiation.
Jessica M. Salmon, Holly Adams, Graham W. Magor, Andrew C. Perkins   +3 more
doaj   +1 more source

Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae

Journal of Immunology Research, 2017
In asthmatic airways, repeated epithelial damage and repair occur. No current therapy directly targets this process. We aimed to determine the effects of mannan derived from S. cerevisiae (SC-MN) on airway epithelial wound repair, in vitro.
Christie F. Michael, Christopher M. Waters, Kim S. LeMessurier, Amali E. Samarasinghe, Chi Y. Song, Kafait U. Malik, D. Betty Lew   +6 more
doaj   +1 more source

TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]

, 2010
Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
core   +1 more source

The Multifaceted Role of Keratinocytes in Hidradenitis Suppurativa Pathogenesis

Experimental Dermatology, Volume 35, Issue 5, May 2026.
ABSTRACT Hidradenitis suppurativa (HS) is a chronic autoinflammatory skin disorder of the pilosebaceous unit, with multiple factors contributing to its onset, activity and progression. Alongside a predisposing genetic background, hormonal and microbiome alterations, dysregulation of innate and adaptive immune response, as well as environmental ...
Chiara Moltrasio, Angelo Valerio Marzano, Maurizio Romagnuolo   +2 more
wiley   +1 more source

Kruppel-like factor 4 regulates neutrophil activation

Blood Advances, 2017
: Neutrophils are the most abundant white blood cells in circulation and are key components of the innate immune response. Clinical and experimental studies support an important role for the neutrophils in a broad spectrum of acute and chronic ...
Yuyan Shen, Hong Hong, Panjamaporn Sangwung, Stephanie Lapping, Lalitha Nayak, Lilei Zhang, Mukesh K. Jain, Xudong Liao   +7 more
doaj   +1 more source

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, Volume 293, Issue 9, Page 2519-2540, May 2026.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch

Scientific Reports, 2017
The Krüppel-like factor (KLF) family of transcription factors play critical roles in haematopoiesis. KLF1, the founding member of the family, has been implicated in the control of both erythropoiesis and megakaryopoiesis.
Laura J. Norton, Samantha Hallal, Elizabeth S. Stout, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley, Kate G. R. Quinlan   +6 more
doaj   +1 more source

Bioinformatics analysis of the early inflammatory response in a rat thermal injury model

BMC Bioinformatics, 2007
Background Thermal injury is among the most severe forms of trauma and its effects are both local and systemic. Response to thermal injury includes cellular protection mechanisms, inflammation, hypermetabolism, prolonged catabolism, organ dysfunction and
Berthiaume Francois, Yarmush Martin L, Maguire Timothy, Yang Eric, Androulakis Ioannis P   +4 more
doaj   +1 more source