Results 151 to 160 of about 10,149 (182)
Role of kruppel-like transcription factors in adipogenesis
Developmental Biology, 2013 The zinc-finger transcription factors of the kruppel-like factor family (KLF) are critical in many physiological and pathological processes including cell proliferation, differentiation, inflammation, and apoptosis. Recently, there is increasing evidence that suggests these KLFs have an important role in fat biology.
Suqing Wang
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Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6 [PDF]
Oncogene, 2004 The Kruppel-like transcription factor KLF6 is a novel tumor-suppressor gene mutated in a significant fraction of human prostate cancer. It is localized to human chromosome 10p14-15, a region that displays frequent loss of heterozygosity in glioblastoma multiforme (GBM).
Alec C Kimmelman +2 more
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Transcriptional repression of the tyrosinase-related protein 2 gene by transforming growth factor-β and the Kruppel-like transcription factor GLI2 [PDF]
Journal of Dermatological Science, 2019 Tyrosinase-Related Protein 2 (TRP2) is an enzyme involved in melanogenesis, that also exerts proliferative, anti-apoptotic and immunogenic functions in melanoma cells. TRP2 transcription is regulated by the melanocytic master transcription factor MITF.
Véronique Marsaud +2 more
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Tissue and Cell, 2022
This study is to investigate the effect of Kruppel-like factor 9 (KLF9) on the occurrence and progression of cholangiocarcinoma (CCA) and its underlying mechanism. After the CCA cells were transfected with OE-KLF9 and/or sh-metallothionein 1 M (sh-MT1M), KLF9 and MT1M expression levels were measured.
Wenhui Chen
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This study is to investigate the effect of Kruppel-like factor 9 (KLF9) on the occurrence and progression of cholangiocarcinoma (CCA) and its underlying mechanism. After the CCA cells were transfected with OE-KLF9 and/or sh-metallothionein 1 M (sh-MT1M), KLF9 and MT1M expression levels were measured.
Wenhui Chen
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Kruppel-like Factor-9 (KLF9) Inhibits Glioblastoma Stemness through Global Transcription Repression and Integrin α6 Inhibition [PDF]
Journal of Biological Chemistry, 2014 It is increasingly important to understand the molecular basis for the plasticity of neoplastic cells and their capacity to transition between differentiated and stemlike phenotypes. Kruppel-like factor-9 (KLF9), a member of the large KLF transcription factor family, has emerged as a regulator of oncogenesis, cell differentiation, and neural ...
Mingyao Ying +2 more
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Archives of Medical Research, 2019 Diabetic nephropathy (DN) is one of the most serious microvascular complications in diabetic patients. The kruppel-like transcription factor-4 (KLF-4) affects the expression of genes involved in the pathogenesis of DN. The present study aims to identify the KLF-4 expression and DNA methylation (DNAMe) status in patients with type-2 diabetes (T2D) and ...
Zeynep Mine Coşkun +2 more
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The transcription factor Gbx2 induces expression of Kruppel-like factor 4 to maintain and induce naïve pluripotency of embryonic stem cells [PDF]
Journal of Biological Chemistry, 2017 The transcription factor Gbx2 (gastrulation brain homeobox 2) is a direct target of the LIF/STAT3 signaling pathway, maintains mouse embryonic stem cell (mESC) self-renewal, and facilitates mouse epiblast stem cell (mEpiSC) reprogramming to naïve pluripotency.
Dahai Liu, Shoudong Ye
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Biochemistry, 2005
Kruppel-like factor 2 (KLF2) is expressed in several cell types, and knockout animals have shown that KLF2 gene regulation is involved in multiple biological processes. These include maintaining T-cells in the quiescent state, preventing preadipocytes from differentiating into mature adipocytes, stabilizing blood vessel walls through endothelial cell ...
Nisar, Ahmad, Jerry B, Lingrel
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Kruppel-like factor 2 (KLF2) is expressed in several cell types, and knockout animals have shown that KLF2 gene regulation is involved in multiple biological processes. These include maintaining T-cells in the quiescent state, preventing preadipocytes from differentiating into mature adipocytes, stabilizing blood vessel walls through endothelial cell ...
Nisar, Ahmad, Jerry B, Lingrel
openaire +2 more sources
Molecular Biology Reports, 2020
AarF domain containing kinase 4 (ADCK4) is identified as a candidate gene associated with hereditary nephrotic syndrome (NS). Kruppel-like factor 5 (KLF5) is reported to promote podocyte survival by blocking the ERK/p38 MAPK pathways. Both ADCK4 and KLF5 are involved in the occurrence and development of podocyte disease, but their interaction remains ...
Xi Chen +4 more
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AarF domain containing kinase 4 (ADCK4) is identified as a candidate gene associated with hereditary nephrotic syndrome (NS). Kruppel-like factor 5 (KLF5) is reported to promote podocyte survival by blocking the ERK/p38 MAPK pathways. Both ADCK4 and KLF5 are involved in the occurrence and development of podocyte disease, but their interaction remains ...
Xi Chen +4 more
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International Journal of Molecular SciencesAtherosclerosis is a leading contributor to cerebrovascular and cardiovascular diseases, which can be driven by multiple pathological processes, including chronic inflammation, lipid dysregulation, and vascular remodeling. Currently, lifestyle intervention and pharmacological intervention, like statins, are recommended in clinical treatments.
Yiyang Cao +5 more
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