Results 41 to 50 of about 10,149 (182)

Promoter keyholes enable specific and persistent multi-gene expression programs in primary T cells without genome modification [PDF]

, 2020
Non-invasive epigenome editing is a promising strategy for engineering gene expression programs, yet potency, specificity, and persistence remain challenging.
Acosta, Reyes, Baker, David, Bates, Daniel, Bloom, Jordan, Boyken, Scott E., Chen, Zibo, Ciarlo, Christie, Dunn, Douglass, Federation, Alexander, Funnell, Alister, Green, Shon, Heberlein, Gregory, Liao, Hanna, Nandakumar, Vivek, Otterman, Ericka, Pearl, Jocelynn, Queitsch, Konstantin, Sandstrom, Richard, Schanzer, Elaine, Stamatoyannopoulos, John A., Urnov, Fyodor D., Van Biber, Benjamin, Vong, Shinny, Wang, Hao, Wilken, Matthew S., Zrazhevskey, Pavel   +25 more
core  

New insights into the anti-inflammatory mechanisms of glucocorticoids : an emerging role for glucocorticoid-receptor-mediated transactivation [PDF]

, 2013
Glucocorticoids are anti-inflammatory drugs that are widely used for the treatment of numerous (autoimmune) inflammatory diseases. They exert their actions by binding to the glucocorticoid receptor (GR), a member of the nuclear receptor family of ...
Dejager, Lien, Libert, Claude, Tuckermann, Jan, Vandevyver, Sofie   +3 more
core   +1 more source

The Role of KLF4 in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2018
Krüppel-like factor 4 (KLF4), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions.
Ziqian Cheng, Xiaohan Zou, Yang Jin, Shuohui Gao, Jiayin Lv, Bingjin Li, Ranji Cui   +6 more
doaj   +1 more source

Transcriptional Activity of Erythroid Kruppel-like Factor (EKLF/KLF1) Modulated by PIAS3 (Protein Inhibitor of Activated STAT3) [PDF]

Journal of Biological Chemistry, 2015
Erythroid Kruppel-like factor (EKLF or KLF1) is a transcription factor crucial for red cell development that is directly involved in regulation of a large number of erythroid genes. EKLF serves mostly as an activator of expression of these genes; however, it can act also as a repressor.
Miroslawa, Siatecka, Shefali, Soni, Antanas, Planutis, James J, Bieker   +3 more
openaire   +2 more sources

Krüppel-like factor 4 control of immune cell function

Frontiers in Immunology
Krüppel-like factor 4 (KLF4) belongs to a family of transcription factors that contain conserved zinc finger DNA binding domains, including specificity proteins (SPs) and Krüppel-like factors (KLFs).
Tapatee Das, Elaine Wang, Yitian Xu, Harrison Yang, Xudong Liao, Mukesh K. Jain, Mukesh K. Jain   +6 more
doaj   +1 more source

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells [PDF]

, 2010
KLF1 regulates a diverse suite of genes to direct erythroid cell differentiation from bipotent progenitors. To determine the local cis-regulatory contexts and transcription factor networks in which KLF1 operates, we performed KLF1 ChIP-seq in the mouse ...
Bailey, Timothy L., Cloonan, Nicole, Gardiner, Brooke B., Grimmond, Sean M., Keys, Janelle R., Nourbakhsh, Ehsan, Perkins, Andrew C., Tallack, Michael R., Wainwright, Elanor N., Whitington, Tom, Yuen, Wai Shan   +10 more
core   +1 more source

Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications.

PLoS ONE, 2012
The Kruppel-like factor (KLF) family of transcription factors regulates diverse cell biological processes including proliferation, differentiation, survival and growth. Previous studies have shown that KLF15 inhibits cardiac hypertrophy by repressing the
Joost J Leenders, Wino J Wijnen, Ingeborg van der Made, Monika Hiller, Melissa Swinnen, Thierry Vandendriessche, Marinee Chuah, Yigal M Pinto, Esther E Creemers   +8 more
doaj   +1 more source

Stress Induced Transcription Factors Transactivate the Herpes Simplex Virus 1 Infected Cell Protein 27 (ICP27) Transcriptional Enhancer

Viruses, 2021
Following acute infection, herpes simplex virus 1 (HSV-1) establishes lifelong latency in neurons, including sensory neurons within trigeminal ganglia. During latency, lytic cycle viral gene expression is silenced.
Jeffery B. Ostler, Clinton Jones
doaj   +1 more source

Increased Complement 3 With Suppression of miR‐145 Induces the Synthetic Phenotype in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We previously reported that vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHRs) show the increased expression of complement 3 (C3) and the synthetic phenotype.
Lan Chen, Noboru Fukuda, Tomoyasu Otsuki, Sho Tanaka, Yoshihiro Nakamura, Hiroki Kobayashi, Taro Matsumoto, Masanori Abe   +7 more
doaj   +1 more source

Cellular reprogramming with multigene activation by the delivery of CRISPR/dCas9 ribonucleoproteins via magnetic peptide-imprinted chitosan nanoparticles

Materials Today Bio, 2021
Induced pluripotent stem cells are usually derived by reprogramming transcription factors (OSKM), such as octamer-binding transcription factor 4 (OCT4), (sex determining region Y)-box 2 (SOX2), Krüppel-like factor 4 (KLF4), and cellular proto-oncogene (c-
Mei-Hwa Lee, Cheng-Chih Lin, James L. Thomas, Jin-An Li, Hung-Yin Lin   +4 more
doaj   +1 more source