Results 21 to 30 of about 1,004 (85)

Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This review explores the complex and self‐reinforcing cycle of mechanical stress, inflammation, and altered vascularity in tendinopathy—a common, painful tendon disorder. It integrates current findings on cellular, molecular, and biomechanical mechanisms, highlighting how mechanical overload, inflammatory signals, and abnormal blood vessel behavior ...
Renate Gehwolf, Herbert Tempfer, Nevra Pelin Cesur, Andrea Wagner, Andreas Traweger, Christine Lehner   +5 more
wiley   +1 more source

Enhancing therapeutic efficacy through degradation of endogenous extracellular matrix in primary breast tumor spheroids

The FEBS Journal, Volume 292, Issue 13, Page 3494-3507, July 2025.
Solid tumors have a complex extracellular matrix (ECM) that can significantly affect tumor behavior and treatment response. Understanding the role of the ECM is therefore critical for understanding tumor biology and improving therapeutic responses. In this study, we isolated primary cells from a DMBA‐induced tumor mass to generate three‐dimensional ...
Alessandra Lo Cicero, Simona Campora, Gabriele Lo Buglio, Paolo Cinà, Margot Lo Pinto, Simone Dario Scilabra, Giulio Ghersi   +6 more
wiley   +1 more source

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

Advanced Science, Volume 12, Issue 23, June 20, 2025.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin, Ye Wu, Xiao‐Hui Liang, Min Tang, Xin Sun, Sheng‐Xin Lu, Jin‐Mei Jin, Xin Guo, Bei Wang, Hong‐Zhuan Chen, Wei‐Dong Zhang, Xin Luan   +11 more
wiley   +1 more source

Early Detection and Longitudinal Follow‐Up of Non‐Invasive Biomarkers for Laryngeal Squamous Cell Carcinoma: First Results of the BEAL‐Study

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Introduction Despite therapeutic and prognostic improvements in the early treatment of laryngeal squamous cell carcinoma (LSCC), screening for early detection of laryngeal cancer has not yet been established. Methods A study has been designed to address this issue based on an analysis of exosomal serum biomarkers for LSCC.
Ann‐Christin Winkelmann, Olaf Wendler, Johannes Schuster, Abbas Agaimy, Marlen Haderlein, Benjamin Frey, Sarina Katrin Mueller   +6 more
wiley   +1 more source

DDX3 participates in miRNA biogenesis and RNA interference through translational control of PACT and interaction with AGO2

FEBS Open Bio, Volume 15, Issue 1, Page 180-195, January 2025.
DDX3 participates in microRNA (miRNA) biogenesis and RNA interference (RNAi) through translational control of protein activator of the interferon‐induced protein kinase (PACT) and interaction with Argonaute 2 (AGO2). (1) DDX3 regulates the translation of PACT, which is critical for efficient precursor miRNA and short hairpin RNA (shRNA) cleavage.
Ming‐Chih Lai, Yen‐Ling Yu, Chiao‐Nung Chen, Jau‐Song Yu, Hsin‐Yuan Hung, Shih‐Peng Chan   +5 more
wiley   +1 more source

Abstracts

Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
wiley   +1 more source

Matricellular Regulation of Alveolar Epithelial Cell Plasticity in Neonatal Lung Injury: Insights from CCN5 and Beyond. [PDF]

Med Res Arch
Fiaturi N, Nielsen HC, Castellot J.
europepmc   +1 more source

WISP-3 facilitates CCL4-dependent monocyte migration and M1 polarization in rheumatoid arthritis by inhibiting miR-6894-5p. [PDF]

Int J Med Sci
Wang GS, Lee KT, Lin SL, Hou SM, Fong YC, Tang CH, Lin CY.   +6 more
europepmc   +1 more source

CCN Proteins as Matricellular Regulators of Bone in Aging and Disease. [PDF]

Curr Osteoporos Rep
Abdul-Azees PA, Rajesh R, Block TJ, Dean DD, Yeh CK, Capitano M, Kacena M, Chen XD, Marinković M.   +8 more
europepmc   +1 more source

Co-Exposure to Lunasin and Other Drugs as a Potential Chemopreventive Strategy Against Breast and Colon Cancers: A Review. [PDF]

Int J Mol Sci
Janiak A, Kaufman-Szymczyk A, Lubecka-Gajewska K.   +2 more
europepmc   +1 more source