Results 81 to 90 of about 1,507 (156)

Population pharmacokinetics of imetelstat, a first‐in‐class oligonucleotide telomerase inhibitor

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 7, Page 1264-1277, July 2024.
Abstract Imetelstat is a novel, first‐in‐class, oligonucleotide telomerase inhibitor in development for the treatment of hematologic malignancies including lower‐risk myelodysplastic syndromes and myelofibrosis. A nonlinear mixed‐effects model was developed to characterize the population pharmacokinetics of imetelstat and identify and quantify ...
Mario González‐Sales, Ashley L. Lennox, Fei Huang, Chandra Pamulapati, Ying Wan, Libo Sun, Tymara Berry, Melissa Kelly Behrs, Faye Feller, Peter N. Morcos   +9 more
wiley   +1 more source

COVID‐19 associated oral and oropharyngeal microbiome: Systematic review and meta‐analysis

Periodontology 2000, Volume 94, Issue 1, Page 603-626, February 2024.
Abstract Three years into the coronavirus disease 2019 (COVID‐19) pandemic, there are still growing concerns with the emergence of different variants, unknown long‐ and short‐term effects of the virus, and potential biological mechanisms underlying etiopathogenesis and increased risk for morbidity and mortality.
Sukirth M. Ganesan, Tabitha K. Peter, Miyuraj H. H. Withanage, Frank Boksa, Erliang Zeng, April Martinez, Shareef M. Dabdoub, Kunaal Dhingra, Yvonne Hernandez‐Kapila   +8 more
wiley   +1 more source

CCoV-II infection induces bax translocation into the mitochondria and bcl-2 decrease.

, 2013
(A) A-72 cells were mock-infected (lane cc, control cells) and CCoV-II infected (4, 8, 12, 24, 36 and 48 h p.i.). The bax and bcl-2 expression was evaluated in the cytosol and in the mitochondrial fractions during the infection; equal amounts of proteins
Luisa De Martino (339970), Giuseppe Iovane (339969), Marco Tafani (339963), Filomena Fiorito (339966), Gabriella Marfè (2527216), Ugo Pagnini (339967)   +5 more
core   +1 more source

The risk of pet animals in spreading severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and public health importance: An updated review

Veterinary Medicine and Science, Volume 10, Issue 1, January 2024.
Dogs and cats are infected with SARS‐CoV‐2 either naturally or experimentally. SARS‐CoV‐2 can be transmitted to dogs and cats through close contact with coronavirus disease 2019 (COVID‐19) infected owners. COVID‐19‐infected owners should limit close contact with their pets and follow hygienic measures.
Sina Salajegheh Tazerji, Rasha Gharieb, Mohammadreza Manouchehri Ardestani, Baharak Akhtardanesh, Farrokhreza Kabir, Bita Vazir, Phelipe Magalhães Duarte, Niloufar Saberi, Ehsan Khaksar, Sadegh Haerian, Mohamed Fawzy   +10 more
wiley   +1 more source

Molecular epidemiology of Canine corona viruses (CCoV) among domestic dogs

, 2015
In this study, enlucidating not only the prevalance of CCoV, important disease of dogs, but also molecular characterization of the viruses with M and S genes based RT-PCR and sequencing were aimed. During this study 100 dogs were sampled.
Kudu, Ayşegül
core  

CCoV-II infection modulates the gene regulation of SIRT3 and SIRT4.

, 2013
(A) To perform Northern blot assay, RNA was extracted from mock-infected (lanes cc, control cells) and infected cells at the indicated times, electrophoresed and hybridized with a labelled probe as described under Material and Methods.
Luisa De Martino (339970), Giuseppe Iovane (339969), Marco Tafani (339963), Filomena Fiorito (339966), Gabriella Marfè (2527216), Ugo Pagnini (339967)   +5 more
core   +1 more source

Isolation and Genomic Characteristics of a Novel Pathogenicity Type I Feline Coronavirus in Mainland China

Transboundary and Emerging Diseases, Volume 2024, Issue 1, 2024.
Feline coronavirus (FCoV) is an enveloped, positive‐sense RNA virus, which is widespread among feline populations, and can cause a fatal serious disease called feline infectious peritonitis (FIP). According to the differences of antigen and genetic composition, FCoV consists of two genotypes, FCoV I and FCoV II.
Yuanhong Wang, Junna Wang, You Zhao, Yun Liu, Miao Zhang, Xiaoying Deng, Jie Zhu, Guoxin Li, Guangqing Liu, Zongfu Wu   +9 more
wiley   +1 more source

EFFECT OF WATER EXTRACT FROM BROWN PROPOLIS ON PRODUCTION OF IFN-γ AFTER IMMUNIZATION AGAINST CANINE PARVOVIRUS (CPV) AND CANINE CORONAVIRUS (CCoV)

, 2015
The purpose of this study was to evaluate the imunnostimulatory adjuvant capacity of water extract from brown propolis (WEBP) when added to a vaccine against canine parvovirus (CPV) and canine coronavirus (CCoV), regarding the production of IFN-γ.
Maureen Hoch Vieira Fernandes (6150020), Lilian das Neves Ferreira (6150023), Geferson Fischer (849988), Gilberto D'Avila Vargas (6150026), Silvia de Oliveira Hübner (6118133)   +4 more
core   +1 more source

HCoV‐HKU1 and TMPRSS2 interaction: uncovering mechanisms of viral invasion

MedComm, Volume 6, Issue 1, January 2025.
Zehan Pang, Huahao Fan, Xiaolong Xu
wiley   +1 more source

In Silico Assessment for Risk of Possible Human Transmission of FCoV‐23

Transboundary and Emerging Diseases, Volume 2024, Issue 1, 2024.
Since the pandemic in 2019, coronaviruses (CoVs) have been a great concern for public health burden. The fact that CoVs can infect all animals including domestic ones and livestock points to a future pandemic even though interaction between human and wildlife animals is restricted. Moreover, interspecies transmission abilities of CoVs by mutations make
Ahmet Caglar Ozketen, Hasan Huseyin Kazan, Cenk Serhan Özverel, Tamer Şanlıdağ, Chunfu Zheng   +4 more
wiley   +1 more source