Results 141 to 150 of about 27,769 (271)

Higher percentage of CD103⁺cells and CD103⁻cells inside the CD8⁺GranzymeB⁺-population in RE.

, 2014
Panel A depicts percentage of CD103+-cells and CD103–cells inside the CD8+GranzymeB+-population in 14 days ex vivo culture of squamous epithelial biopsies from controls (C SQ 5 cm: 5 cm above the Z-line) and BE patients (BE SQ 5 cm: 5 cm above the BE ...
Leo Koenderman (278722), Johannes G. Kusters (109529), Peter D. Siersema (109521), Alexandra Lind (327452)   +3 more
core   +1 more source

Diminished CD103 (aEb7) Expression on Resident T cells from the Female Genital Tract of HIV-positive women

Pathogens and Immunity, 2017
Background:Tissue resident memory T cells (TrM) provide an enhanced response against infection at mucosal surfaces, yet their function has not been extensively studied in humans, including the female genital tract (FGT).
David C. Moylan, Paul A. Goepfert, Mirjam-Colette Kempf, Michael S. Saag, Holly E. Richter, Jiri Mestecky, Steffanie Sabbaj   +6 more
doaj   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

GM-CSF promotes development of CD103⁺ DCs and expression of CD103 in young and adult mice, respectively.

, 2014
Analysis of lung DC subsets in (A–C) 6–8 week-old and (D–E) 6-day-old mice. (A, D) Gated cells in dot plots show CD103+ and CD11b+ DCs with values indicating percentages among CD11c+Siglec-F− lung DCs. Cells were pre-gated on CD45+eFluor780− viable cells.
Manfred Kopf (224264), Alex K. Heer (546912), Glynis Klinke (546913), Nico van Rooijen (4110211), Johannes Vogel (515351), Michael Kurrer (224262), Samuel P. Nobs (546911), Christoph Schneider (413360)   +7 more
core   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Higher frequency of peripheral blood CD103+CD8+ T cells with lower levels of PD-1 and TIGIT expression related to favorable outcomes in leukemia patients

Frontiers in Immunology
BackgroundLeukemia is a prevalent pediatric life-threatening hematologic malignancy with a poor prognosis. Targeting immune checkpoints (ICs) to reverse T cell exhaustion is a potentially effective treatment for leukemia.
Lian Liu, Lian Liu, Wenpu Lai, Wenpu Lai, Wenpu Lai, Xiaoling Zhuo, Sihui Chen, Sihui Chen, Xiaodan Luo, Xiaodan Luo, Huo Tan, Huo Tan   +11 more
doaj   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

CD103+CD8+ tissue‐resident memory T lymphocytes of melanoma boost anti‐tumour immunity and predict immunotherapy outcomes

Clinical and Translational Medicine
Background Immunotherapy has revolutionised melanoma treatment, providing significant clinical benefits by reactivating the anti‐tumour immune system. CD8+ tissue‐resident memory T lymphocytes (CD8+ TRM) have emerged as crucial mediators of anti‐tumour ...
Tianyi Zhang, Junquan Song, Yinlam Li, Kangjie Shen, Jiangying Xuan, Yuan Gao, Lili Lu, Zhi Pang, Lu Wang, Yang Yang, Zixu Gao, Qianrong Hu, Yu Zhu, Chenlu Wei, Shaoluan Zheng, Rongkui Luo, Yingyong Hou, Yuhong Zhou, Chuanyuan Wei, Jianying Gu   +19 more
doaj   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source