Results 231 to 240 of about 27,769 (271)
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Preparation and identification of monoclonal antibodies against porcine CD103
Applied Microbiology and Biotechnology, 2022Dendritic cells (DCs) play an important role in activating, regulating, and maintaining the immune response. CD103+ DCs, one of the DC subpopulations, mainly function in the mucosal immune response. They are responsible for capturing and carrying antigens to the relevant lymph nodes to activate the downstream immune responses. However, there is limited
Tao Zhang +10 more
openaire +2 more sources
International Immunopharmacology, 2015
CD103 plays an important role in the destruction of islet allografts, and previous studies found that a CD103 immunotoxin (M290-Saporin, or M290-SAP) promoted the long-term survival of pancreatic islet allografts. However, systemic toxicity to the host and the bystander effects of M290-SAP obscure the underlying mechanisms of action and restrict its ...
Yuanyi, Mang +5 more
openaire +2 more sources
CD103 plays an important role in the destruction of islet allografts, and previous studies found that a CD103 immunotoxin (M290-Saporin, or M290-SAP) promoted the long-term survival of pancreatic islet allografts. However, systemic toxicity to the host and the bystander effects of M290-SAP obscure the underlying mechanisms of action and restrict its ...
Yuanyi, Mang +5 more
openaire +2 more sources
Journal of Controlled Release, 2022
Current methods of STING activation based on intra-tumoral injections of cyclic dinucleotides (CDNs) are not suitable for addressing tumor heterogeneity or for inaccessible, metastatic and abscopal tumors.
Aatman S Doshi +4 more
semanticscholar +1 more source
Current methods of STING activation based on intra-tumoral injections of cyclic dinucleotides (CDNs) are not suitable for addressing tumor heterogeneity or for inaccessible, metastatic and abscopal tumors.
Aatman S Doshi +4 more
semanticscholar +1 more source
CD103 blockade impair anti-CTLA-4 immunotherapy in oral cancer.
Oral Oncology, 2023OBJECTIVES CD103+CD8+T cells is a subtype of T cells with excellent tumor killing ability and it could response to immune checkpoint blockade therapy in several types of cancer, but the phenotype, role and molecular mechanism CD103+CD8+T cells in the ...
Yao Xiao +7 more
semanticscholar +1 more source
Intestinal CD103+CD4+ and CD103+CD8+ T-Cell Subsets in the Gut of Inflammatory Bowel Disease Patients at Diagnosis and During Follow-Up [PDF]
Inflammatory Bowel Diseases, 2019 AbstractBackgroundThe integrin CD103 is proposed to be a potential therapeutical target in inflammatory bowel disease (IBD), as it can form a heterodimeric integrin with β7 (Etrolizumab, anti-β7 integrin) on epithelial T cells. Therefore, we aimed to study the frequencies of different intestinal CD103+T-cell subsets, both CD4+ and CD8+, in newly ...
Britt Roosenboom +2 more
exaly +3 more sources
Expression of inflammatory mediators in CD103+ and CD103- T cells isolated from periodontitis tissue
2023Despite the important role of tissue - resident memory T (TRM) cells in immunity and pathology of mucosal tissues, the study of tissue-resident memory T cells in periodontitis tissues is limited. Previous investigation in our laboratory identified the localization of TRM (CD103+ T cells) in periodontitis tissue.
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CD103 and Intratumoral Immune Response in Breast Cancer
Clinical Cancer Research, 2016Abstract Purpose: CD103 is expressed in several immune cell types but in the context of the intratumoral immune response may be most important as a marker of antigen-activated CD8 T cells. Methods: We have examined the prognostic significance of CD103 TILs in breast cancer by IHC in a cohort of 424 breast cancer ...
Zhi-Qiang, Wang +5 more
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Secondary infections rejuvenate the intestinal CD103+ tissue-resident memory T cell pool
Science immunology, 2022Resident T lymphocytes (TRM) protect tissues during pathogen reexposure. Although TRM phenotype and restricted migratory pattern are established, we have a limited understanding of their response kinetics, stability, and turnover during reinfections ...
Madlaina von Hoesslin +8 more
semanticscholar +1 more source
Distinct recirculation potential of CD69+CD103− and CD103+ thymic memory CD8+ T cells
Immunology & Cell Biology, 2016Tissue‐resident memory T (TRM) cells occupy peripheral and lymphoid tissues where they confer protection against local infection. While epithelial CD8+ TRM cells coexpress CD69 and CD103, CD103− memory cells have been described in various organs and are often presumed non‐recirculating based on their expression of CD69.
Simone L, Park +2 more
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Journal of Immunology, 2023
Dermal regulatory T cells (Tregs) are essential for maintenance of skin homeostasis and control of skin inflammatory responses. In mice, Tregs in the skin are characterized by high expression of CD103, the αE integrin.
M. Norman +7 more
semanticscholar +1 more source
Dermal regulatory T cells (Tregs) are essential for maintenance of skin homeostasis and control of skin inflammatory responses. In mice, Tregs in the skin are characterized by high expression of CD103, the αE integrin.
M. Norman +7 more
semanticscholar +1 more source