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Pretargeted Anti-CD20 Radioimmunotherapy with scFv Fusion Protein Safely Combines with BEAM and ASCT in Patients with High-risk B-cell Lymphomas. [PDF]
Mol Cancer TherOrozco JJ +10 more
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Glofitamab CD20-TCB bispecific antibody
Leukemia & Lymphoma, 2021Bispecific T-cell recruiting antibodies are emerging as a potent immunotherapeutic class in the treatment of B-cell malignancies and act by simultaneously targeting antigens on T-cells and malignant cells to effect tumor cell death. Glofitamab is a novel full-length IgG-like CD20-CD3 bispecific with a unique 2:1 configuration that provides an extended ...
Adrian, Minson, Michael, Dickinson
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Veterinary Immunology and Immunopathology, 2005
The human CD20 antigen, a 35kDa cell surface nonglycosylated hydrophobic phoshpoprotein is expressed consistently on almost all human B-cells, and its monoclonal antibody is used for the therapy on human B-cell lymphoma. In the present study, canine CD20 gene was cloned and sequenced, and the expression of CD20 mRNA was investigated in canine ...
Rui, Kano +7 more
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The human CD20 antigen, a 35kDa cell surface nonglycosylated hydrophobic phoshpoprotein is expressed consistently on almost all human B-cells, and its monoclonal antibody is used for the therapy on human B-cell lymphoma. In the present study, canine CD20 gene was cloned and sequenced, and the expression of CD20 mRNA was investigated in canine ...
Rui, Kano +7 more
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Papillary thyroid carcinoma expressing CD20
Pathology International, 2017We identified a case of lymphadenopathy of metastatic papillary thyroid carcinoma (PTC) with CD20 expression, which was also expressed by the primary tumor. CD20 expression was identified using immunohistochemistry (IHC) in metastatic PTC biopsy samples from a 58‐year‐old woman.
Yuya, Sasaki +6 more
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Info Onkologie, 2016
Follikulare Lymphome (FL) werden meist im fortgeschrittenen Stadium entdeckt, sodass eine palliative Therapie gefragt ist. Bei vorbehandelten Patienten mit Progress steht nun mit Obinutuzumab plus Bendamustin eine wirksame Alternative zur Verfugung.
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Follikulare Lymphome (FL) werden meist im fortgeschrittenen Stadium entdeckt, sodass eine palliative Therapie gefragt ist. Bei vorbehandelten Patienten mit Progress steht nun mit Obinutuzumab plus Bendamustin eine wirksame Alternative zur Verfugung.
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2015
The CD20 inhibitors are protein constructs which bind and inactivate CD20. They are members of a group of drugs active in rheumatoid arthritis known as biological disease-modifying antirheumatic drugs (bDMARDs). They are not included in the group slow-acting antirheumatic drugs (SAARDs) because they are considered to have more specific actions and ...
Pile, Kevin (R17082) +2 more
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The CD20 inhibitors are protein constructs which bind and inactivate CD20. They are members of a group of drugs active in rheumatoid arthritis known as biological disease-modifying antirheumatic drugs (bDMARDs). They are not included in the group slow-acting antirheumatic drugs (SAARDs) because they are considered to have more specific actions and ...
Pile, Kevin (R17082) +2 more
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CD20-negative follicular lymphoma
Diagnostic Histopathology, 2012Abstract Follicular lymphoma is one of the commoner diagnosed Non-Hodgkin Lymphomas (NHL) of adults in the North America and Europe. It is a B-cell lymphoma, composed of neoplastic centrocytes and centroblasts that express the pan-B cell antigens CD20 and CD79a and the follicle centre markers CD10 and bcl-6.
Orla H. O'Mahony, Annette Riley
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Immunotherapy with anti-CD20 compounds
Seminars in Cancer Biology, 2003The B-cell surface antigen CD20 is currently the prime target for near-selective treatment of mature B-cell malignancies and a range of reactive B-cell associated disorders (including virus-associated lymphoproliferation or autoimmune conditions). CD20 is strongly and homogeneously expressed on the majority of mature B-cell neoplasms except chronic ...
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Inhibitory FcγRIIb and CD20 internalization
Blood, 2014In this issue of Blood, Vaughan et al demonstrate that certain antibodies that are used therapeutically in lymphoma treatment (e.g., rituximab) undergo Fcg receptor IIb (FcgRIIb)–mediated internalization from the B-cell surface in a manner that is independent of activation of FcgRIIb with important implications for the design of antibody-based ...
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