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Анти-CD20-терапия и планирование беременности при рассеянном склерозе

Хачанова Наталья Валерьевна, Краснов Владимир Сергеевич, Евдошенко Евгений Петрович, Закройщикова Инесса Владимировна, Касаткин Дмитрий Сергеевич, Коробко Денис Сергеевич, Котий Светлана Александровна, Кузнецов Павел Андреевич, Новикова Екатерина Сергеевна, Попова Екатерина Валериевна, Тотолян Наталья Агафоновна, Трифонова Наталья Сяитовна, Шумилина Мария Васильевна, Якушина Татьяна Игоревна, Давыдовская Мария Вафаевна   +14 more
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Sequential Antigen-loss and Branching Evolution in Lymphoma after CD19- and CD20-Targeted T-cell Redirecting Therapy.

Blood, 2023
CD19 CAR T-cells and CD20 targeting T-cell engaging bispecific antibodies have been approved in B-cell Non-Hodgkin lymphoma lately, heralding a new clinical setting where patients are treated with both approaches, sequentially.
Johannes Duell, A. Leipold, S. Appenzeller, Viktoria Fuhr, Hilka Rauert-Wunderlich, M. D. Da Vià, O. Dietrich, C. Toussaint, Fabian Imdahl, F. Eisele, Nazia Afrin, Lars Grundheber, H. Einsele, Niels Weinhold, Andreas Rosenwald, Max S. Topp, A. Saliba, L. Rasche   +17 more
semanticscholar   +1 more source

Proinflammatory CD20+ T cells contribute to CNS-directed autoimmunity

Science Translational Medicine, 2022
The origin and function of CD20+ T cells are poorly understood. Here, we characterized CD20+ T cells in mice and humans and investigated how they are affected by anti-CD20 antibody treatment. We report that murine CD20+ T cells are unable to endogenously
Jasmin Ochs, Nitzan Nissimov, Sebastian Torke, M. Freier, Katja Grondey, J. Koch, M. Klein, L. Feldmann, C. Gudd, T. Bopp, Silke Häusser-Kinzel, Martin S. Weber   +11 more
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Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models

Science Translational Medicine, 2021
Trispecific duoCAR-T cells with optimized costimulatory domains effectively kill tumor cells in antigen-heterogeneous and antigen-replete tumor models.
D. Schneider, Y. Xiong, Darong Wu, Peirong Hu, Leah M. Alabanza, Brittany L. Steimle, Hasan Mahmud, K. Anthony-Gonda, W. Krueger, Zhongyu Zhu, D. Dimitrov, R. Orentas, B. Dropulić   +12 more
semanticscholar   +1 more source