Results 351 to 360 of about 168,682 (384)

Single-Cell Sequence and Machine Learning Identify a CD79A+B Cells-Related Transcriptional Signature for Predicting Clinical Outcomes and Immune Microenvironment in Breast Cancer. [PDF]

Cancer Inform
Hu H, Zhan W, Zhu H, Hao B, Yan T, Zhang J, Wang S, Zhang T.   +7 more
europepmc   +1 more source

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Sequential Antigen-loss and Branching Evolution in Lymphoma after CD19- and CD20-Targeted T-cell Redirecting Therapy.

Blood, 2023
CD19 CAR T-cells and CD20 targeting T-cell engaging bispecific antibodies have been approved in B-cell Non-Hodgkin lymphoma lately, heralding a new clinical setting where patients are treated with both approaches, sequentially.
Johannes Duell, A. Leipold, S. Appenzeller, Viktoria Fuhr, Hilka Rauert-Wunderlich, M. D. Da Vià, O. Dietrich, C. Toussaint, F. Imdahl, F. Eisele, Nazia Afrin, Lars Grundheber, H. Einsele, Niels Weinhold, Andreas Rosenwald, Max S. Topp, A. Saliba, L. Rasche   +17 more
semanticscholar   +1 more source

Proinflammatory CD20+ T cells contribute to CNS-directed autoimmunity

Science Translational Medicine, 2022
The origin and function of CD20+ T cells are poorly understood. Here, we characterized CD20+ T cells in mice and humans and investigated how they are affected by anti-CD20 antibody treatment. We report that murine CD20+ T cells are unable to endogenously
Jasmin Ochs, Nitzan Nissimov, Sebastian Torke, M. Freier, Katja Grondey, Julian Koch, M. Klein, L. Feldmann, Cathrin Gudd, T. Bopp, Silke Häusser-Kinzel, Martin S. Weber   +11 more
semanticscholar   +1 more source

Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models

Science Translational Medicine, 2021
Trispecific duoCAR-T cells with optimized costimulatory domains effectively kill tumor cells in antigen-heterogeneous and antigen-replete tumor models.
D. Schneider, Y. Xiong, Darong Wu, Peirong Hu, Leah M. Alabanza, Brittany L. Steimle, Hasan Mahmud, K. Anthony-Gonda, W. Krueger, Zhongyu Zhu, D. Dimitrov, R. Orentas, B. Dropulić   +12 more
semanticscholar   +1 more source

FMC7 is an epitope of CD20

Blood, 2008
To the editor: The FMC7 antibody, originally described in 1981,[1][1] detects an antigen expressed on mature human B cells and is used in immunophenotypic analysis and differential diagnosis of lymphomas and leukemias. The identity of the FMC7 antigen was unclear for many years.
Julie P. Deans, Maria J. Polyak
openaire   +3 more sources

Canine CD20 gene

Veterinary Immunology and Immunopathology, 2005
The human CD20 antigen, a 35kDa cell surface nonglycosylated hydrophobic phoshpoprotein is expressed consistently on almost all human B-cells, and its monoclonal antibody is used for the therapy on human B-cell lymphoma. In the present study, canine CD20 gene was cloned and sequenced, and the expression of CD20 mRNA was investigated in canine ...
Rui, Kano, Chika, Inoiue, Hiromi, Okano, Junpei, Yamazaki, Tomoko, Takahashi, Toshihiro, Watari, Mikihiko, Tokuriki, Atsuhiko, Hasegawa   +7 more
openaire   +2 more sources

Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.

Journal of Clinical Oncology, 1998
PURPOSE The CD20 antigen is expressed on more than 90% of B-cell lymphomas. It is appealing for targeted therapy, because it does not shed or modulate.
P. Mclaughlin, A. Grillo‐López, B. Link, R. Levy, M. Czuczman, Michael E. Williams, M. Heyman, I. Bence-Bruckler, C. White, F. Cabanillas, V. Jain, A. Ho, J. Lister, K. Wey, D. Shen, B. Dallaire   +15 more
semanticscholar   +1 more source

Engineering CD20 CARs with a Twist

Cancer Immunology Research, 2023
CD20 is highly expressed in several types of B-cell lymphoma and is an intuitive target for chimeric antigen receptor (CAR) T-cell therapy. However, with conventional approaches, it has been challenging to provide CD20 CAR designs that confer efficacy in preclinical models and in clinical trials.
Lukas Scheller, Michael Hudecek
openaire   +2 more sources