Results 171 to 180 of about 389,148 (301)

Functional and Proteomic Profiles of CD3(+) Plasma-Derived Small Extracellular Vesicles Differentiate Cancer Patients From Healthy Donors. [PDF]

Eur J Immunol
Widlak P, Han J, Gluszko A, Mika J, Zebrowska A, Mondal SK, Gawin M, Najjar YG, Polańska J, Pietrowska M, Whiteside TL.   +10 more
europepmc   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Separation of plasma‐derived exosomes into CD3(+) and CD3(–) fractions allows for association of immune cell and tumour cell markers with disease activity in HNSCC patients

Clinical and Experimental Immunology, 2018
M. Theodoraki, T. Hoffmann, T. Whiteside
semanticscholar   +1 more source

Could the Immune Modulation of Invariant Natural Killer T Cell and the Expression of CD244 and CD196 on Natural Killer Cell Subtypes Impact the Treatment Outcomes of Acute Myeloid Leukemia Patients? [PDF]

J Hematol
Zahran AM, Rayan A, Refaat A, Elsayh AKI, Hussein NYH, Sabet MA, Seif Eldin S, Fergany A, Narouz MW, Mahboob YR, Albadry M Zahran Z.   +10 more
europepmc   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

The Thymic Microenvironment Shapes Age-Related Qualitative Changes in the TCR Repertoire. [PDF]

Aging Cell
Rowell J, Yanez DC, Ross S, Lau CI, Zhang E, Monfared A, Peña OA, Chain B, Crompton T.   +8 more
europepmc   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Selected signalling proteins recruited to the T‐cell receptor–CD3 complex

Immunology, 2018
Jatuporn Ngoenkam, W. Schamel, S. Pongcharoen   +2 more
semanticscholar   +1 more source

Comparative Immunopathology of Toxoplasma gondii Natural Infections in Marmosets (Callithrix spp.) and Howler Monkeys (Alouatta spp.), Brazil. [PDF]

J Med Primatol
Pellegrino M, Santos ALM, Dos Santos Cirqueira C, da Silva Gagliotti GFP, Ewbank AC, Sacristán C, Ressio RA, Fernandes NCCA, Guerra JM, Catão-Dias JL.   +9 more
europepmc   +1 more source