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Deciphering CD30 ligand biology and its role in humoral immunity
Immunology, 2006 SummaryLigands and receptors in the tumour necrosis factor (TNF) and tumour necrosis factor receptor (TNFR) superfamilies have been the subject of extensive investigation over the past 10–15 years. For certain TNFR family members, such as Fas and CD40, some of the consequences of receptor ligation were predicted before the identification and cloning of
Mary K, Kennedy +2 more
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Trogocytosis of ligand–receptor complex and its intracellular transport in CD30 signalling
Biology of the Cell, 2018Background InformationCD30, which is characteristically expressed in classical Hodgkin lymphoma (cHL), is thought to transduce signals by ligation of trimerised CD30 ligand (CD30L) on the surface of surrounding cells and recruitment of downstream molecules. In this report, we propose a new mechanism for CD30 signalling by its ligand.
Ryouichi HORIE, Kaoru Uchimaru
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Thyroid, 2001
Because the CD30 ligand (CD30L)/CD30 receptor (CD30) system is expressed in certain malignancies, but has not been studied in thyroid nodules, we investigated its immunohistochemical expression in 6 normal thyroids (NT) and 131 thyroid nodules: 28 colloid nodules (CN), 45 adenomas (15 oncocytic [OA], 30 follicular [FA]) and 58 carcinomas (15 follicular
TROVATO, Maria Concetta +10 more
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Because the CD30 ligand (CD30L)/CD30 receptor (CD30) system is expressed in certain malignancies, but has not been studied in thyroid nodules, we investigated its immunohistochemical expression in 6 normal thyroids (NT) and 131 thyroid nodules: 28 colloid nodules (CN), 45 adenomas (15 oncocytic [OA], 30 follicular [FA]) and 58 carcinomas (15 follicular
TROVATO, Maria Concetta +10 more
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Molecular Immunology, 1994
CD30L, the ligand for the activation antigen CD30, is a member of the tumor necrosis factor family of cytokines. Binding of CD30L to CD30, which is a member of the nerve growth factor/tumor necrosis factor receptor family, induces proliferation in peripheral blood lymphocytes and Hodgkin's derived cell lines with a T-cell phenotype such as HDLM-2 and ...
Michael Pfreundschuh +2 more
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CD30L, the ligand for the activation antigen CD30, is a member of the tumor necrosis factor family of cytokines. Binding of CD30L to CD30, which is a member of the nerve growth factor/tumor necrosis factor receptor family, induces proliferation in peripheral blood lymphocytes and Hodgkin's derived cell lines with a T-cell phenotype such as HDLM-2 and ...
Michael Pfreundschuh +2 more
exaly +3 more sources
CD30 Ligand Is Frequently Expressed in Human Hematopoietic Malignancies of Myeloid and Lymphoid Origin [PDF]
Blood, 1997 AbstractCD30 ligand (CD30L) is a type-II membrane glycoprotein capable of transducing signals leading to either cell death or proliferation through its specific counterstructure CD30. Although several lines of evidence indicate that CD30L plays a key role as a paracrine- or autocrine-acting surface molecule in the deregulated cytokine cascade of ...
Massimo Degan +2 more
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CD30 Ligand: Cloning, Characterisation and Biological Activities
1995Hodgkin’s disease (HD) is characterised by the presence of a small number (< 1% of total tumour mass) of the typical, presumed malignant Hodgkin and Reed-Sternberg (H-RS) cells in a hyperplastic background of normal, reactive lymphocytes, plasma cells, histiocytes, neutrophils, eosinophils, and stromal cells.
Hans-Jürgen. Gruss, Steven. K. Dower
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Expression of CD30 and CD30 ligand in cultured cell lines from human germ-cell tumors.
Laboratory investigation; a journal of technical methods and pathology, 1997Embryonal carcinoma (EC) cells are the multipotent stem cells of human teratocarcinomas. EC cell lines isolated from human testicular teratocarcinomas retain pluripotentiality and show cell-surface marker phenotype and growth characteristics similar to those of primate embryonic stem cells.
M F, Pera, W, Bennett, D P, Cerretti
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CD30 and its ligand: Possible role in regulation of teratoma stem cells
Apmis, 1998Like the oocyte, the cells of the early embryo, and primordial germ cells, human teratocarcinoma stem cells are pluripotent, capable of giving rise to a wide range of somatic and extraembryonic tissues. Growth factors which regulate the growth of multipotent stem cells in the mouse have been identified, but none of these have been shown conclusively to
Martin Pera +2 more
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Characterization of the murine CD30 ligand (CD153) gene: Gene structure and expression
Tissue Antigens, 2002Abstract: CD153 (CD30 ligand) has been described as a 40‐kDa type II transmembrane glycoprotein belonging to the TNF superfamily and is expressed primarily by activated T cells, B cells and monocytes. In this study, we have determined that the murine CD153 gene consists of four exons, with three intervening introns, spaced over approximately 26 kb of ...
L C, Goldie-Cregan +2 more
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CD30 ligand is expressed on resting normal and malignant human B lymphocytes
British Journal of Haematology, 1996CD30, a member of the tumour necrosis receptor superfamily, is physiologically expressed on a subpopulation of T helper cells in normal individuals but is also expressed on several malignant and virally transformed cells. Its ligand (CD30L) is a pleiotropic cellular transmembrane protein that can induce cell death in several CD30+ cell lines.
A, Younes +7 more
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