Results 1 to 10 of about 23,011 (205)

Beyond CD30: Dual‐Targeting of Malignant and Regulatory T Cells by Brentuximab Vedotin Remodels the Lymphoma Microenvironment and Overcomes Resistance via BCL2 Inhibition in Mycosis Fungoides [PDF]

Advanced Science
Mycosis fungoides (MF), the most common subtype of cutaneous T cell lymphoma (CTCL), has a poor prognosis in advanced stages. Brentuximab vedotin (BV), a CD30‐targeting antigen‐drug conjugate approved for CD30+ MF following prior systemic treatment ...
Yi Jiang, Pan Lai, Mingjia Li, Yujie Wen, Mengzhou Cao, Yu Xiao, Zhuojing Chen, Jingru Sun, Yang Wang   +8 more
doaj   +2 more sources

Blocking CD30 on CD19 CAR T cells augments their functional capacities against B-cell leukemia/lymphoma [PDF]

Frontiers in Immunology
Adoptive therapy with CD19 chimeric antigen receptor (CAR) T cells is effective against B-cell malignancies; however, T-cell activation rapidly declines, increasing the risk of early leukemia relapses.
Tim Schlierkamp-Voosen, Markus Barden, Helena Janning, Marcell Kaljanac, Dennis Christoph Harrer, Celine Dreger, Kathrin Hammon, Moritz Ertelt, Moritz Ertelt, Clara T. Schoeder, Clara T. Schoeder, Hólmfridur Rósa Halldórsdóttir, Carlos Rodriguez-Pardo, Sine Reker Hadrup, Simone Thomas, Simone Thomas, Hinrich Abken   +16 more
doaj   +2 more sources

CD30-CD30 Ligand Interaction in Primary Cutaneous CD30+T-Cell Lymphomas: A Clue to the Pathophysiology of Clinical Regression [PDF]

Blood, 1999
Primary CD30+ cutaneous T-cell lymphomas (CTCLs) represent a spectrum of non-Hodgkin’s lymphomas (NHLs) that have been well defined at the clinical, histologic, and immunologic level. This group, which includes 2 main entities (large cell lymphoma and lymphomatoid papulosis [LyP]) and borderline cases, is characterized by the expression of CD30 antigen
Maggi E
exaly   +4 more sources

Synergistic adverse prognostic impact of CD30 and Epstein–Barr virus in peripheral T-cell lymphoma: CD30 identifies a high-risk subgroup in Epstein–Barr virus–encoded RNA -positive patients [PDF]

Annals of Hematology
Patients with Epstein–Barr virus–encoded RNA (EBER)-positive Peripheral T-cell lymphoma (PTCL) exhibit poor survival. Current prognostic scores lack efficacy in this group, necessitating more specific biological markers.
Ze-Tao Chen, Ling Huang, Xiao-Dan Zhang, Ning Wang, Xin-Miao Jiang, Xiao-Juan Wei, Hong Zhang, Han-Guo Guo, Cai-Di Lin, Fei-Li Chen, Si-Chu Liu, Zhan-Li Liang, Wen-Yu Li   +12 more
doaj   +2 more sources

CD30 in Systemic Mastocytosis

Immunology and Allergy Clinics of North America, 2014
CD30 is a transmembrane receptor, normally not expressed by mast cells, which regulates proliferation/apoptosis and antibody responses. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis.
, Hanneke N G Oude Elberink, Philip M Kluin   +2 more
exaly   +3 more sources

CD30 knockout attenuates experimental colitis by reducing inflammatory cytokine production [PDF]

BMC Immunology
Background Inflammatory bowel disease (IBD) is characterized by dysregulated T helper immune responses. Crohn’s disease is predominantly associated with excessive Th1 and Th17 responses, while ulcerative colitis displays a more heterogeneous immune ...
Lili Guo, Zhaocai He, Changqing Yang, Xiaorong Chen, Juan Wang   +4 more
doaj   +2 more sources

Immunoexpression of CD30 and CD30 ligand in deciduas from spontaneous abortions

European Journal of Histochemistry, 2009
In the present study, using immunohistochemistry, we studied the expression of CD30 and CD30-L in 35 deciduas obtained from women following elective abortion during normal physiological gestation and in 60 deciduas obtained from women after spontaneous ...
M Trovato, M Grosso, E Vitarelli, M Le Donne, V Barresi, F Trimarchi, G Barresi   +6 more
doaj   +6 more sources

Research note: Marek's disease oncogene Meq directly regulates CD30 high expression through binding to two regions in promoter [PDF]

Poultry Science
Marek's disease (MD), caused by the oncogenic Marek's disease virus (MDV), is a lymphoproliferative disease in chickens and serves as a natural animal model for CD30-overexpressing lymphomas.
Yushuang Du, Gang Zheng, Yuqin Yang, Jiannan Zhang, Juan Li, Ling Lian   +5 more
doaj   +2 more sources

Detection of CD30 expression in lymphomas: status and challenges [PDF]

Zhongguo aizheng zazhi, 2022
CD30, a member of tumor necrosis factor receptor family, is expressed in a variety of lymphoma subtypes, such as classic Hodgkin lymphoma (CHL) and anaplastic large cell lymphoma (ALCL).
LI Xiaoqiu, CD30 Positive Lymphoma Pathology Expert Group
doaj   +3 more sources

CD30-Positive Extracellular Vesicles Enable the Targeting of CD30-Negative DLBCL Cells by the CD30 Antibody-Drug Conjugate Brentuximab Vedotin

Frontiers in Cell and Developmental Biology, 2021
CD30, a member of the TNF receptor superfamily, is selectively expressed on a subset of activated lymphocytes and on malignant cells of certain lymphomas, such as classical Hodgkin Lymphoma (cHL), where it activates critical bystander cells in the tumor ...
Liudmila Lobastova, Liudmila Lobastova, Liudmila Lobastova, Liudmila Lobastova, Marcus Lettau, Marcus Lettau, Felix Babatz, Thais Dolzany de Oliveira, Thais Dolzany de Oliveira, Thais Dolzany de Oliveira, Thais Dolzany de Oliveira, Phuong-Hien Nguyen, Phuong-Hien Nguyen, Phuong-Hien Nguyen, Phuong-Hien Nguyen, Bianca Alves Pauletti, Astrid C. Schauss, Horst Dürkop, Ottmar Janssen, Adriana F. Paes Leme, Michael Hallek, Michael Hallek, Michael Hallek, Michael Hallek, Hinrich P. Hansen, Hinrich P. Hansen, Hinrich P. Hansen, Hinrich P. Hansen   +27 more
doaj   +1 more source