Results 41 to 50 of about 23,011 (205)

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Characterization of CD123 expression by mast cells in systemic mastocytosis with multicolor flow cytometry

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Systemic mastocytosis (SM) is a clonal mast cell (MC) disorder characterized by aberrant immunophenotypes, including expression of CD25, CD2, and occasionally CD30. CD123, the α‐subunit of the interleukin‐3 receptor, is a therapeutic target in hematologic malignancies and has been reported to be expressed on neoplastic MCs by ...
Ryan C. Shean, Tracy I. George, David P. Ng   +2 more
wiley   +1 more source

Novel anti-CD30/CD3 bispecific antibodies activate human T cells and mediate potent anti-tumor activity

Frontiers in Immunology, 2023
CD30 is expressed on Hodgkin lymphomas (HL), many non-Hodgkin lymphomas (NHLs), and non-lymphoid malignancies in children and adults. Tumor expression, combined with restricted expression in healthy tissues, identifies CD30 as a promising immunotherapy ...
Mary L. Faber, Robyn A. A. Oldham, Robyn A. A. Oldham, Archana Thakur, Mary Jo Rademacher, Ewa Kubicka, Theresa A. Dlugi, Steven A. Gifford, William M. McKillop, Nathan J. Schloemer, Lawrence G. Lum, Jeffrey A. Medin, Jeffrey A. Medin, Jeffrey A. Medin   +13 more
doaj   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL FAILURE AND HEMODIALYTIC PATIENTS

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2008
BACKGROUND AND OBJECTIVE: Various abnormalities of the immune system have been demonstrated in patients on hemodialysis. Imbalances in Th1 and Th2 responses have an important role in these complications.
AR Rafiei,, A Makhlough, S Hashemi Nasab, MR Mahdavi, AM Mirabi   +4 more
doaj  

Hodgkin lymphoma of the ampulla of Vater: A rare cause of obstructive jaundice in children

JPGN Reports, EarlyView.
Abstract Hodgkin lymphoma (HL) has a wide spectrum of presentation. Most cases affect lymph nodes (nodal), while extranodal involvement is rare. Whereas the gastrointestinal tract is enriched with lymphoid tissues, the ampulla of Vater is not rich in lymphoid tissue. Involvement of the ampulla of Vater with HL has rarely been reported in adults and has
Sultana Alshammari, Homoud Alhebbi, Awad Al Qahtani, Sarah Algubaisi, Faisal Alhaffaf, Abdulrahman Al Robayan, Mohammed Almutairi, Saeed Alshieban, Mohammad Alshahrani, Tarek Khaled Alfawzan, Khalid Alkhamis, Ibrahim Al Hasan, Sami Wali   +12 more
wiley   +1 more source

Prevalence of Colonization, Association With Disease Stage and Effect of Eradication of Staphylococcus aureus in Cutaneous T‐Cell Lymphoma: A Systematic Review and Meta‐Analysis

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Cutaneous T‐cell lymphoma (CTCL) is a rare and heterogeneous group of skin‐homing lymphomas with a largely unknown pathogenesis. Staphylococcus aureus (S. aureus) colonization has been implicated in exacerbating CTCL, particularly in advanced stages. Objectives This study assessed the prevalence of S.
Ida Lind Holm, Sarah Søltoft Rasmussen, Somaia Naassan, Misbah N. Ghazanfar, Kenneth Thomsen, Rikke Bech, Lise M. Lindahl, Maria Kamstrup, Simon Francis Thomsen, Zarqa Ali   +9 more
wiley   +1 more source

The Evolving Role of Brentuximab Vedotin in Classical Hodgkin Lymphoma

Blood and Lymphatic Cancer: Targets and Therapy, 2019
Catherine Lai,1 Adrese Michael Kandahari,1 Chaitra Ujjani2 1Lombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital, Washington, DC, USA; 2Seattle Cancer Care Alliance, Fred Hutchinson CRC, University of Washington, Seattle, WA ...
Lai C, Kandahari AM, Ujjani C
doaj  

Brentuximab Vedotin‐Induced Rash Sparing CD30‐Positive Mycosis Fungoides Lesions

JEADV Clinical Practice, EarlyView.
ABSTRACT Brentuximab vedotin (BV) is an effective treatment for CD30‐positive lymphomas, including mycosis fungoides (MF). However, its use can be associated with various cutaneous adverse effects, including rashes. This case describes a 60‐year‐old male with stage IIB MF who developed a drug‐induced erythematous rash after three infusions of BV ...
Isabel Hariri, Alexander H. Enk, Jessica C. Hassel   +2 more
wiley   +1 more source

CD19 and CD30 CAR T-Cell Immunotherapy for High-Risk Classical Hodgkin’s Lymphoma

Frontiers in Oncology, 2021
BackgroundIn clinical applications of CAR T-cell therapy, life-threatening adverse events including cytokine release syndrome and neurotoxicity can lead to treatment failure. Outcomes of patients treated with anti-CD30 CAR T- cell have been disappointing
YuanBo Xue, YuanBo Xue, Xun Lai, RuiLei Li, ChunLei Ge, BaoZhen Zeng, Zhen Li, QiaoFen Fu, LiuFang Zhao, SuWei Dong, JinYan Yang, JiYin Guo, QingYin Meng, QingHua Tan, ZhenHui Li, HaiYan Ding, YanLei Zhang, ShaoHui Liu, Alex H. Chang, Hong Yao, RongCheng Luo   +20 more
doaj   +1 more source