Results 201 to 210 of about 92,785 (261)

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani, Remco G. A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T. M. Putmans, Freya M. C. H. Huijsmans, Lyanne J. P. M. Sijbers, Aafke M. De Ligt, Maurice J. H. Van Haaren, Rianne C. Scholman, Noël M. M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastiaan J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source

Hydrogel-Dependent Angiogenic Sprouting in the Ex Vivo Aortic Ring Assay: A Comparative Functional Approach for Biomaterial Evaluation. [PDF]

J Funct Biomater
Götz L, Dogan L, Wörsdörfer P, Chicaiza-Cabezas NA, Ergün S, Groll J, Kleefeldt F.   +6 more
europepmc   +1 more source

CD248/Endosialin Regulates Synovial Fibroblast State to Control Coupling of Inflammation and Bone Damage in Murine Models of Immune‐Mediated Inflammatory Arthritis and Aging

Arthritis &Rheumatology, EarlyView.
Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/endosialin is expressed by fibroblasts in the synovium, is highly up‐regulated during inflammation, and has been proposed as a potential therapeutic target.
Samuel Kemble, Corinna Wehmeyer, James M. Brown, Charlotte G. Smith, Holly R. Adams, Eva Crombie, Ellie Northall, Maryam Imran, Paulynn Chin, Harris R. Perlman, Christopher D. Buckley, Adam P. Croft, Amy J. Naylor   +12 more
wiley   +1 more source

MYZAP promotes angiogenesis by targeting RND1 after myocardial infarction. [PDF]

iScience
Xuan L, Wang G, Li X, Wang S, Gao Y, Wang J, Zhang H, Zhuang S, Luo H, Guo J, Zhang M, Yang X, Zhang H, Zhang Q, Qiao Y, Kang K, Zhang Y, Sun L.   +17 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

LGMN regulates endothelial-to-mesenchymal transition via the p38 MAPK pathway to promote pulmonary fibrosis. [PDF]

Funct Integr Genomics
Zou Y, Zhang J, Chen D, Zhang Y, Fan J, Cai K.   +5 more
europepmc   +1 more source

Mechanistic Study of Platelet Membrane-Coated Resveratrol Nanosystem in Mitochondrial Dysfunction and Endothelial Senescence During Atherosclerotic Lesion Development via FOXM1 Activation. [PDF]

Aging Cell
Xiao L, Zhan Z, Liu P, Qin B.
europepmc   +1 more source

Integrated Epidemiological and Extracellular Vesicle Profiling Identifies miR-126-3p, miR-21-5p, miR-92a-3p and SNAIL as Candidate Biomarkers of Endothelial Dysfunction and Cardio-Metabolic Risk. [PDF]

Int J Mol Sci
Gómez-Grosso LA, Montoya Ortiz GE, Osorio-Méndez JJ, Aulestia-Vacca MP, Iza Rodríguez SN, Forero Torres AY.   +5 more
europepmc   +1 more source

Understanding Channel Complementarity for Multiplex Cell Segmentation. [PDF]

ACM BCB
Ma H, Lin Y, Godschall E, Matuck B, Byrd KM, Peng Y, Liu J.   +6 more
europepmc   +1 more source

Retiform hemangioendothelioma of the breast: a case report and considerations for effective management. [PDF]

J Surg Case Rep
Papanikolaou GE, Merkouris SA, Giannaki KP, Papaefthymiou ZE, Douvetzemis SE.   +4 more
europepmc   +1 more source