Results 211 to 220 of about 138,386 (251)
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A conformation- and avidity-based proofreading mechanism for the TCR–CD3 complex
Trends in Immunology, 2006During antigen recognition, T cells show high sensitivity and specificity, and a wide dynamic range. Paradoxically, these characteristics are based on low-affinity receptor-ligand interactions [between the T-cell antigen receptor (TCR-CD3) complex and the antigen peptide bound to MHC].
Schamel, Wolfgang +4 more
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CD3/TCR Complex-Associated Lymphocyte Activation Gene-3 Molecules Inhibit CD3/TCR Signaling
The Journal of Immunology, 1998Abstract The lymphocyte activation gene-3 (LAG-3) molecule is a T cell activation Ag closely related to CD4 at the gene and protein levels. We investigated whether LAG-3 itself may down-regulate the immune response by interfering with TCR signaling.
S, Hannier +3 more
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The Journal of Immunology, 1992
Abstract The TCR is composed of two chains (alpha/beta) containing variable regions associated at the cell surface with invariant chains (CD3 gamma-, delta-, epsilon-, and zeta/eta chains). The latter control assembly and surface expression of the TCR/CD3 complex, as well as its cytoplasmic association with signal transduction relays. In
Buferne, M. +8 more
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Abstract The TCR is composed of two chains (alpha/beta) containing variable regions associated at the cell surface with invariant chains (CD3 gamma-, delta-, epsilon-, and zeta/eta chains). The latter control assembly and surface expression of the TCR/CD3 complex, as well as its cytoplasmic association with signal transduction relays. In
Buferne, M. +8 more
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Transmembrane signalling through the T-cell-receptor-CD3 complex
Current Opinion in Immunology, 1993Recent data support the existence of activation motifs within different subunits of the T-cell-receptor-CD3 complex. This architecture generates a receptor composed of discrete modules, each capable of being coupled to an effector pathway. Although new T-cell specific protein tyrosine kinases have recently been identified, the nature of the proximal ...
B, Malissen, A M, Schmitt-Verhulst
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The conformation of the CD3 complex on T lymphocytes is modified by calcium ions
European Journal of Immunology, 1989AbstractWhile calcium ions are known to play a prominent role in signal transduction in the activation of T lymphocytes, its mechanism of action, target and function have not been elucidated. One crucial event in the calcium‐dependent process is the activation of the CD3 complex, and this, too, is not understood. While studying the release of Ca2+ from
J P, Breittmayer +3 more
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Assembly of the T Cell Receptor/CD3 Complex
1989The human T cell receptor for antigens is a multichain cell surface receptor consisting of variable (TCR -α/β or TCR -γ/δ and constant elements (CD3 — γ δeζThe exquisite specificity for antigen plus MHC (or CD1) resides in the variable regions of the TCR α/β (or TCR — γ /δ) glycoproteins (1, 2, 3).
C. Terhorst +10 more
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[Expression anomalies of the CD3-TCR complex expression and immunodeficiencies].
Medecine sciences : M/S, 2007Molecular characterization of immunodeficiencies contributes to a better understanding of the physiological mechanisms of immune function. The T cell receptor is a heterodimer (alpha/beta or gamma/delta) associated with four transmembrane units of the CD3 complex (gamma, delta, epsilon and zeta).
Françoise, Le Deist +4 more
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Pre-TCR/CD3 and TCR/CD3 complexes: decamers with differential signalling properties?
Immunology today, 1998Currently, the favoured model for the structure of the T-cell receptor (TCR)/CD3 complex proposes a monovalent TCR alpha beta/CD3 gamma epsilon delta epsilon zeta zeta octameric complex. However, other biochemical, structural and functional data point to a bivalent (TCR alpha beta)2/CD3 gamma epsilon delta epsilon zeta zeta decameric organization ...
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Assembly and stoichiometry of the TCR/CD3 complex
Immunology Letters, 1997E. San José, B. Alarcón
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On the complexity of human CD3− intraepithelial lymphocytes
Gastroenterology, 2004Francisco, Leon, Garbiñe, Roy
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