Results 221 to 230 of about 807,388 (265)

Targeting the HPGDS-PGD₂ axis to treat Th17 cell-mediated autoimmunity in multiple sclerosis. [PDF]

Signal Transduct Target Ther
Zhuang Y, Lei K, Li Y, Deng W, Yue J, Wan J, Wu Q, Lu Q, Tang Y, Rasko JEJ, Liu J, Monteiro O, Bian X, Qiu W, Li T.   +14 more
europepmc   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Machine-learning model for distinguishing cytomegalovirus infection status in hospitalised patients with systemic lupus erythematosus: a retrospective cohort study with temporal validation. [PDF]

BMJ Open
Qin L, Hong J, Liu J, Zhou S, Liu J, Cao W, Wu Q, Zeng X, Li T.   +8 more
europepmc   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

IL-6 receptor inhibition promotes expansion of cytolytic CD4+ T cells after cellular immunotherapy.

Blood
Williams CG, Zhang P, Adams RC, Gong H, Haeseleer F, Olver SD, Engel JA, Bhise SS, Lee HJ, Moreira ML, Furlan SN, Haque A, Varelias A, Hill GR.   +13 more
europepmc   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Task shifting of point-of-care testing to lay health workers in rural primary health facilities in Nsanje, Malawi. [PDF]

Glob Health Action
Ndlovu Z, Burton R, Steenssens M, Makwale K, Maleka S, Madaliso G, Chapweteka G, Mphande-Nyasulu F, Kabwe E, Falconer J, Steele SJ, Ellman T, Casas EC, Fatti G.   +13 more
europepmc   +1 more source

A human self-stimulatory CD4+ T cell antigen-presenting cell subset presents and recognizes agonistic self-antigens to sustain exponential autologous clonal expansion. [PDF]

J Immunol
Smallwood CK, Sneed SL, Williford CL, Roof TS, Mannie MD.   +4 more
europepmc   +1 more source