Results 11 to 20 of about 580,131 (264)

Dynamics of hydrogen bonds in the secondary structures of allosteric protein Avena Sativa phototropin 1

open access: yesComputational and Structural Biotechnology Journal, 2022
The Light-Oxygen-Voltage 2 (LOV2) domain of Avena Sativa phototropin 1 (AsLOV2) protein is one of the most studied domains in the field of designing photoswitches.
Mayar Tarek Ibrahim   +2 more
doaj   +1 more source

Explore Protein Conformational Space With Variational Autoencoder

open access: yesFrontiers in Molecular Biosciences, 2021
Molecular dynamics (MD) simulations have been actively used in the study of protein structure and function. However, extensive sampling in the protein conformational space requires large computational resources and takes a prohibitive amount of time.
Hao Tian   +5 more
doaj   +1 more source

Ex vivo expanation T CD4+ and T CD8+ isolated from human peripheral blood mononuclear cells

open access: yesTạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2022
Immunotherapy is currently an attractive method in the treatment of cancer. Immune cells are isolated, activated, ex vivo proliferated, functionally manipulation and then given back into the patient.
Phùng Thị Việt Anh   +2 more
doaj   +1 more source

Viral Load And Cd4+ among Hiv/Aids Patients Receiving Antiretroviral Therapy In Jayawijaya District, Papua Province, Indonesia

open access: yesFolia Medica Indonesiana, 2022
Hightlight:• Clinical conditions, CD4+ cell counts, and the viral copies number in the blood for AIDS/HIV were given antiretroviral therapy. • The profile of CD4+ levels and plasma viral load in HIV patients receiving antiretroviral therapy • The lower ...
Mirna Widiyanti   +4 more
doaj   +1 more source

Role of B cell activating factor in the development of periodontitis

open access: yes口腔疾病防治, 2020
B cell activating factor (BAFF) is the key regulator of B cells and is considered as a potential therapeutic target for immune inflammatory diseases.
ZHANG Zheng, WANG Zuomin
doaj   +1 more source

Dynamical Behavior of β-Lactamases and Penicillin- Binding Proteins in Different Functional States and Its Potential Role in Evolution

open access: yesEntropy, 2019
β-Lactamases are enzymes produced by bacteria to hydrolyze β-lactam-based antibiotics, and pose serious threat to public health through related antibiotic resistance.
Feng Wang   +3 more
doaj   +1 more source

Machine Learning Classification Model for Functional Binding Modes of TEM-1 β-Lactamase

open access: yesFrontiers in Molecular Biosciences, 2019
TEM family of enzymes is one of the most commonly encountered β-lactamases groups with different catalytic capabilities against various antibiotics. Despite the studies investigating the catalytic mechanism of TEM β-lactamases, the binding modes of these
Feng Wang   +5 more
doaj   +1 more source

Epidemiology and results of the first line therapy for HIV-related Hodgkin lymphoma

open access: yesУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022
Introduction. The risk of developing Hodgkin lymphoma (HL) with HIV infection is higher than in the general population, and the course of the disease itself is more aggressive.
A. M. Chekalov   +17 more
doaj   +1 more source

Insights into the interaction of CD4 with anti-CD4 antibodies

open access: yesImmunobiology, 2017
Knowledge about the mechanism by which some antibodies can block HIV-1 entry is critical to our understanding of their function and may offer new avenues for controlling the adhesion of HIV-1 to the host cells. While much progress has been made, this mechanism remains unclear.
Van-Chien, Bui, Thi-Huong, Nguyen
openaire   +2 more sources

Laboratory biomarkers and immunological modulation of sintilimab in gastric cancer: A meta-analysis focused on tumor markers and T-cell subsets [PDF]

open access: yesJournal of Medical Biochemistry
Background: Sintilimab, a PD-1 inhibitor, has emerged as a promising immunotherapeutic agent in gastric cancer. However, its impact on laboratory-based biochemical markers and immune indicators remains underexplored.
Zhang Xian   +6 more
doaj   +1 more source

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