Results 141 to 150 of about 594,874 (263)

Task shifting of point-of-care testing to lay health workers in rural primary health facilities in Nsanje, Malawi. [PDF]

Glob Health Action
Ndlovu Z, Burton R, Steenssens M, Makwale K, Maleka S, Madaliso G, Chapweteka G, Mphande-Nyasulu F, Kabwe E, Falconer J, Steele SJ, Ellman T, Casas EC, Fatti G.   +13 more
europepmc   +1 more source

CD4 [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Aging-associated SATB1 deficiency remodels 3D genome architecture and transcriptional programs in naive CD4⁺ T cells. [PDF]

Sci Adv
Wang B, Ji L, Bian Q.
europepmc   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Associations Between Gut Microbiota and Immune Profiles in Community-Dwelling Older Adults and the Regulatory Role of Polygonatum odoratum. [PDF]

Aging Cell
Xia T, Wu H, Cui T, Yang W, Zhang M, Huang Y, Zhou S, Wu Y, Yan D, Jia F, Zhang L, Cui Z, An J, Zhong X, Lv B, Zhao X, Niu K, Gao X.   +17 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Injury polarized CD4⁺ T cells orchestrate redox and unfolded protein responses to promote cardiac repair after myocardial infarction. [PDF]

Redox Biol
Knight TW, Saaoud F, Asangwe N, Shao Y, Khan I, Kubo H, Khan M, Wang H, Kishore R, Yang X, Mohsin S.   +10 more
europepmc   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

IL-23-engineered oncolytic vaccinia virus enhances pancreatic cancer control through inflammasome-driven Th17-skewed CD4⁺ T-cell responses. [PDF]

J Immunother Cancer
Guo Y, Wang M, Xuan Y, Pan L, Yan W, Cheng J, Yu Y, Wang X, Xu L, Sun X, Han R, Si L, Wang Y, Li S, Wang P.   +14 more
europepmc   +1 more source