Results 321 to 330 of about 229,337 (378)

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44⁺ nasopharyngeal carcinoma cancer stem‑like cells. [PDF]

Oncol Rep
Xu X, Liu Y, Su J, Li D, Hu J, Huang Q, Lu M, Liu X, Ren J, Chen W, Sun L.   +10 more
europepmc   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

ROS-responsive graphene-hyaluronic acid nanomedicine for targeted therapy in renal ischemia/reperfusion injury. [PDF]

Theranostics
Lee S, Suh SH, Ma SK, Kim J, Park S, Kim SW, Lee JY.   +6 more
europepmc   +1 more source

circNR3C2 promotes chondrogenic differentiation and cartilage repair of human adipose‐derived stem cells via the hsa‐miR‐647/SOX9 pathway

Animal Models and Experimental Medicine, EarlyView.
The hypothesis diagram illustrates the function and mechanism of circNR3C2: circNR3C2 overexpression can up‐regulate COL2, Aggrecan and SOX9 expression, and regulate chondrogenic differentiation of hADSCs by targeting hsa‐miR‐647. Abstract Background Human adipose‐derived stem cells (hADSCs) are seed cells with application prospects in cartilage repair.
Dabiao Hou, Huajun Wang, Hao Guo, Dongbin Luo, Xiaofei Zheng, Simin Luo   +5 more
wiley   +1 more source

Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Angewandte Chemie, EarlyView.
Electrostatically layered nanoparticles (NPs) coated with anionic polypeptides selectively target cancer cells by engaging amino acid transporters. Poly(L‐glutamate) (PLE) coatings cluster the glutamine transporter SLC1A5, prolonging NP surface retention, while poly(L‐aspartate) (PLD) coatings also bind SLC1A3, potentially promoting faster ...
Ivan S. Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering, Eva Cai, Gonzalo J. Esparza, Mae L. Pryor, Alexander D. Stoneman, Aidan Kindopp, Darrell J. Irvine, Paula T. Hammond   +10 more
wiley   +2 more sources

SPP1 regulates tumor progression through modulation of signaling pathways and the tumor microenvironment. [PDF]

Discov Oncol
Feng Y, Shao X, Xu ZF, Liu P, Wu H, Cheng Y, Qi M, Meng H, Zhang B, Jian FZ, Chen Z, Duan W.   +11 more
europepmc   +1 more source

Advances and Challenges in Micro/Nanocarrier‐Based Dermal Drug Delivery Systems for Acne Treatment

Advanced NanoBiomed Research, EarlyView.
Topical acne treatment faces challenges from skin barriers and complex causes. Micro/nanocarriers improve drug delivery by enhancing bioavailability, targeting, and duration. Combining carriers creates synergistic effects for systematic intervention.
Jintao Yang, Jie Chen, Yunmiao Ma, Qingwei Zhou, Yu Kong, Yingxiang Chen, Junjie Chi, Haihua Hu   +7 more
wiley   +1 more source

Tumor-intrinsic redox programming drives an SPP1-CD44 axis of immune suppression in uveal melanoma. [PDF]

Redox Biol
Ge T, Yang Y, Zhang W, Li M, Gu X, Yang L, Jia R, Wang X, Fan X, Zhuang A.   +9 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Epithelial-Mesenchymal Transition and Stress Adaptations Underlie Yttrium-90 Resistance in Liver Cancer Cell Lines. [PDF]

Cancer Res Commun
Zheleznyak A, Duraiyan D, Thunuguntla P, Camacho J, Wu S, Liu J, Weber JD, Thorek DLJ, Strnad BS, Fields RC, Ciorba MA, Yoon C, Blanc V, Davidson N, Silva-Fisher J, Malone CD.   +15 more
europepmc   +1 more source