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CD44 in hematological neoplasias
Annals of Hematology, 2011The CD44 protein family spans a large group of transmembrane glycoproteins acquired by alternative splicing and post-translational modifications. The great heterogeneity in molecular structure is reflected in its various important functions: CD44 mediates (1) interaction between cell and extracellular matrix, (2) signal submission, e.g., by acting as ...
Magdalena Katharina, Hertweck +2 more
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Expression of CD44s and CD44 splice variants in human melanoma
Oncology Reports, 2002The ability of tumor cells to adhere and detach from extracellular matrix and endothelial cells, is a crucial step in the metastatic process and may alter the clinical prognosis of some human tumors such as melanomas. CD44, the major cell surface receptor for hyaluronate, has been implicated in cell adhesion and in tumor progression.
Stella Maris, Ranuncolo +10 more
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The International Journal of Biochemistry & Cell Biology, 2002
CD44 is a widely expressed cell surface hyaluronan receptor which plays a key role in mediating cell migration. A number of recent papers demonstrating an interplay between CD44 and matrix metalloproteinases (MMPs) have shed important insights into the molecular mechanisms underlying these events.
Clare M, Isacke, Helen, Yarwood
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CD44 is a widely expressed cell surface hyaluronan receptor which plays a key role in mediating cell migration. A number of recent papers demonstrating an interplay between CD44 and matrix metalloproteinases (MMPs) have shed important insights into the molecular mechanisms underlying these events.
Clare M, Isacke, Helen, Yarwood
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CD44: From adhesion molecules to signalling regulators
Nature reviews. Molecular cell biology, 2003H. Ponta, L. Sherman, P. Herrlich
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CD44-Based Detection of CSCs: CD44 Immunodetection by Flow Cytometry
CD44 has been described in many malignancies as a marker of cancer stem cells (CSCs). Several techniques can be used to detect these cells. Here we detail CD44 detection by flow cytometry, a precise technique allowing to determine the percentage of positive cells and the mean fluorescent intensity reflecting the CD44 expression by cells in the samples.Lornella, Seeneevassen +2 more
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CD44 is the principal cell surface receptor for hyaluronate
Cell, 1990A. Aruffo +4 more
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1996
CD44 has been implicated to act in processes such as lymphocyte homing, hematopoiesis, tumor dissemination, lymphocyte activation, pattern formation in embryogenesis, and inflammatory reactions. Possible explanations for the supposedly multipurpose nature of CD44 include the existence of an enormous number of isoforms and/or the potential likelihood ...
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CD44 has been implicated to act in processes such as lymphocyte homing, hematopoiesis, tumor dissemination, lymphocyte activation, pattern formation in embryogenesis, and inflammatory reactions. Possible explanations for the supposedly multipurpose nature of CD44 include the existence of an enormous number of isoforms and/or the potential likelihood ...
openaire +2 more sources