Results 71 to 80 of about 9,091 (172)
Association of CD46 Cellular Receptor Gene SNP in Measles Vaccine Response
The Iraqi Journal of Medical Sciences, 2021 Background: Measles is a highly contagious viral disease. It remains an important cause of death among young children globally, despite the availability of a safe and effective vaccine.
Sarah A.J. Al-Gburi +2 more
doaj +4 more sources
PLoS ONE, 2011 BackgroundAdequate termination of an immune response is as important as the induction of an appropriate response. CD46, a regulator of complement activity, promotes T cell activation and differentiation towards a regulatory Tr1 phenotype.
Siobhan Ni Choileain +5 more
doaj +1 more source
Decoding the Factor H‐Related Proteins: Gatekeepers of Complement Dysregulation in AMD
European Journal of Immunology, Volume 56, Issue 6, June 2026.This review will explore the role of the factor H‐related (FHR) proteins in age‐related macular degeneration (AMD), their accumulation in the outer blood/retinal barrier, and how they may contribute to barrier dysfunction and inflammation. ABSTRACT Age‐related macular degeneration (AMD) is the third most common form of blindness in the Western world ...
Jiaqi Tang +2 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, Volume 40, Issue 12, June 2026.We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu +9 more
wiley +1 more source
Human CD46 aberrant splicing in transgenic mice
Gene, 1997 RNA analysis of mice transgenic for human CD46 reveals almost undetectable levels of the expected transcript and the accumulation of a 900 nt shorter species. cDNA cloning and sequence analysis of this variant demonstrate an aberrant splicing of the transgene RNA.
L C, Mulder, M, Rossini, M, Mora
openaire +2 more sources
Adenovirus interactions with CD46 on transgenic mouse erythrocytes
Virology, 2010 Hemagglutination is an established method but has not been used previously to determine the efficacy of virus binding to a specific cellular receptor. Here we have utilized CD46-expressing erythrocytes from a transgenic mouse to establish whether and to what extent the species B adenoviruses (Ads) as well as Ad37 and Ad49 of species D can interact with
Andersson, Emma K. +2 more
openaire +2 more sources
Molecular Therapy, 2013 We have developed a technology that depletes the complement regulatory protein (CRP) CD46 from the cell surface, and thereby sensitizes tumor cells to complement-dependent cytotoxicity triggered by therapeutic monoclonal antibodies (mAbs). This technology is based on a small recombinant protein, Ad35K++, which induces the internalization and subsequent
Beyer, Ines +15 more
openaire +2 more sources
Frontiers in Immunology, 2018 The aberrant expression of human endogenous retrovirus (HERV) elements of the HERV-W family has been associated with different diseases, including multiple sclerosis (MS).
Benjamin Charvet +6 more
doaj +1 more source
CD46 as a Measles Receptor: Form Follows Function
Virology, 2000 Measles is the seventh leading cause of childhood mortality worldwide. Currently 30–40 million measles infections occur each year, leading to 1–2 million deaths. In addition to causing an acute respiratory infection, measles is associated with a profound, transient suppression of cell-mediated immunity.
Manchester, Marianne +2 more
openaire +2 more sources