Results 1 to 10 of about 1,266,783 (261)

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Frontiers in Immunology, 2022
Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal ...
Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Zoltán Prohászka, Anna Erdei, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi, Mihály Józsi   +16 more
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Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton

Communications Biology
Overexpression of complement genes in the tumor microenvironment, including Factor H (FH), is a strong predictor of poor prognosis in multiple cancers. Its canonical functions in the bloodborne complement cascade, though, cannot explain this prognostic ...
Mikel Rezola Artero, Andrea Minery, Margot Revel, Angela Armento, Mohamed-Ali Jarboui, Idris Boudhabhay, Marina de Castro Deus, Alessandra Zarantonello, Emma Fleury, Lou Segarra, Alaeddine Redissi, Nicolas S. Merle, Marie-Agnes Dragon-Durey, Catherine Monnot, Catherine Sautes-Fridman, Jordan D. Dimitrov, Wolf Herman Fridman, Marius Ueffing, Lubka T. Roumenina   +18 more
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Long-term safety and efficacy of the combination of belimumab and rituximab in the treatment of severe and refractory SLE: a preliminary report

Lupus Science and Medicine
Objective Combination therapy with rituximab and belimumab is a novel treatment strategy for severe SLE and lupus nephritis. Phase II studies have shown promising results, although long-term data are currently lacking.
Tineke Kraaij, Cees van Kooten, Y K Onno Teng, Tom Huizinga, Eline J Arends, Robbert J Goekoop, Ton Rabelink, Mieke van Schaik, Marjolein J A L Wetzels, Stéphanie H Verbruggen, Sandra W van der Kooij, Sylvia W A Kamerling   +11 more
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Case Report: Combined Liver-Kidney Transplantation to Correct a Mutation in Complement Factor B in an Atypical Hemolytic Uremic Syndrome Patient

Frontiers in Immunology, 2021
Pathogenic gain-of-function variants in complement Factor B were identified as causative of atypical Hemolytic Uremic syndrome (aHUS) in 2007. These mutations generate a reduction on the plasma levels of complement C3.
Margarita López-Trascasa, Margarita López-Trascasa, Ángel Alonso-Melgar, Marta Melgosa-Hijosa, Marta Melgosa-Hijosa, Laura Espinosa-Román, Laura Espinosa-Román, María Dolores Lledín-Barbancho, Eugenia García-Fernández, Santiago Rodríguez de Córdoba, Santiago Rodríguez de Córdoba, Pilar Sánchez-Corral, Pilar Sánchez-Corral   +12 more
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BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

Nature Communications, 2017
BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and ...
Adonia E. Papathanassiu, Jeong-Hun Ko, Martha Imprialou, Marta Bagnati, Prashant K. Srivastava, Hong A. Vu, Danilo Cucchi, Stephen P. McAdoo, Elitsa A. Ananieva, Claudio Mauro, Jacques Behmoaras   +10 more
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Correction to: Immunological features of patients affected by Barraquer-Simons syndrome

Orphanet Journal of Rare Diseases, 2020
Following the publication of the original article [1], the authors have requested to amend the Abstract and Discussion section as follows.
Fernando Corvillo, Giovanni Ceccarini, Pilar Nozal, Silvia Magno, Caterina Pelosini, Sofía Garrido, Alberto López-Lera, Manuela Moraru, Carlos Vilches, Silvia Fornaciari, Sabrina Gabbriellini, Ferruccio Santini, David Araújo-Vilar, Margarita López-Trascasa   +13 more
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The Murine Factor H-Related Protein FHR-B Promotes Complement Activation

Frontiers in Immunology, 2017
Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of sequence identity to respective domains of the alternative pathway complement inhibitor factor H (FH). While such FHR proteins
Marcell Cserhalmi, Ádám I. Csincsi, Zoltán Mezei, Anne Kopp, Mario Hebecker, Barbara Uzonyi, Mihály Józsi   +6 more
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Factor H Family Proteins in Complement Evasion of Microorganisms

Frontiers in Immunology, 2017
Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Mihály Józsi
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Nephritic Factors: An Overview of Classification, Diagnostic Tools and Clinical Associations

Frontiers in Immunology, 2019
Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation.
Fernando Corvillo, Fernando Corvillo, Marcin Okrój, Pilar Nozal, Pilar Nozal, Pilar Nozal, Marta Melgosa, Marta Melgosa, Pilar Sánchez-Corral, Pilar Sánchez-Corral, Margarita López-Trascasa, Margarita López-Trascasa   +11 more
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Immunological features of patients affected by Barraquer-Simons syndrome

Orphanet Journal of Rare Diseases, 2020
Background C3 hypocomplementemia and the presence of C3 nephritic factor (C3NeF), an autoantibody causing complement system over-activation, are common features among most patients affected by Barraquer-Simons syndrome (BSS), an acquired form of partial ...
Fernando Corvillo, Giovanni Ceccarini, Pilar Nozal, Silvia Magno, Caterina Pelosini, Sofía Garrido, Alberto López-Lera, Manuela Moraru, Carlos Vilches, Silvia Fornaciari, Sabrina Gabbriellini, Ferruccio Santini, David Araújo-Vilar, Margarita López-Trascasa   +13 more
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