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The Complement System of Agnathans [PDF]
Frontiers in Immunology, 2018 Agnathans (lamprey and hagfish) are a group of primitive jawless fish. Jawed vertebrates possess adaptive immunity including immunoglobulins, while agnathans lack immunoglobulins but have alternative adaptive immunity in which variable lymphocyte ...
Misao Matsushita
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A new perspective on the pathophysiology of kidney diseases: the intracellular complement system- “complosome” [PDF]
Frontiers in NephrologyThe complement cascade is a vital component of the innate immune system. It consists of around 50 proteins, including circulating complement proteins and membrane-bound receptors. It operates through three main activation pathways: classical, lectin, and
Emre Leventoğlu, Sevcan A. Bakkaloğlu
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Complement System: An Immunotherapy Target in Colorectal Cancer
Frontiers in Immunology, 2022 Colorectal cancer (CRC) is the third most common malignant tumor and the second most fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer including the innate complement system.
Iman M. Talaat +7 more
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Congenital Human Cytomegalovirus and the Complement System [PDF]
VirusesCongenital human cytomegalovirus (HCMV) infection is the most common vertically transmitted viral infection, and it affects 1 in 200 live births worldwide.
Andrea Canto Garon +2 more
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The complement system in lipid-mediated pathologies [PDF]
Frontiers in ImmunologyThe complement system, a coordinator and facilitator of the innate immune response, plays an essential role in maintaining host homeostasis. It promotes clearance of pathogen- and danger-associated molecular patterns, regulates adaptive immunity, and can
Lejla Alic +2 more
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Biomarkers of the Complement System in Cancer [PDF]
Medeniyet Medical JournalObjective: Cancer is a disease characterized by an unregulated division of abnormal cells in the body. The discovery of oncogenes and tumor suppressor genes has paved the way for the targeted use of individual biomarkers and proteins in cancer therapy ...
Elif KUBAT OKTEM
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Complement system part II: role in immunity
Frontiers in Immunology, 2015 The complement system has been considered for a long time as a simple lytic system, aimed to kill bacteria infecting the host organism. Nowadays this vision has changed and it is well accepted that complement is a complex innate immune surveillance ...
Nicolas S. Merle +4 more
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Targeting the Roots of Kidney Disease: Systematic Review of the Therapies Targeting the Complement System [PDF]
MedicinaBackground/Objectives: The field of nephrology is increasingly embracing advanced treatments and clinical trials that focus on inhibiting specific components of the complement cascade, a key driver in complement-mediated kidney diseases.
Maja Roman, Michał Nowicki
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COVID-19, Pre-Eclampsia, and Complement System
Frontiers in Immunology, 2021 COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with thrombotic events.
Chiara Agostinis +7 more
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Terminal Complement Pathway Deficiency in an Adult Patient with Meningococcal Sepsis
Case Reports in Immunology, 2022 The complement system is an essential part of our innate immune system. Three enzymatic activation pathways are described, all converging into a common terminal pathway which causes lysis of the target cell.
F. Staels +8 more
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