Results 41 to 50 of about 19,068,086 (301)
Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]
, 2012 Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel +25 more
core +1 more source
Frontiers in Immunology, 2018 The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases.
József Dobó +2 more
doaj +1 more source
An update on the role of complement in hepatocellular carcinoma
Frontiers in Immunology, 2022 As a main producer of complement, the environment in the liver is greatly affected by the complement system. Although the complement system is considered to have the ability of nonself discrimination, remarkable studies have revealed the tight ...
Zhijie Xiao +3 more
doaj +1 more source
Complement-Coagulation Cross-Talk: A Potential Mediator of the Physiological Activation of Complement by Low pH. [PDF]
, 2015 The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
H. I. Kenawy (7637687) +2 more
core +3 more sources
Acidosis activates complement system in vitro
Mediators of Inflammation, 1998 We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12)
Michael Emeis +5 more
doaj +1 more source
Pitfalls in complement analysis: A systematic literature review of assessing complement activation
Frontiers in Immunology, 2022 BackgroundThe complement system is an essential component of our innate defense and plays a vital role in the pathogenesis of many diseases. Assessment of complement activation is critical in monitoring both disease progression and response to therapy ...
Ricardo J. M. G. E. Brandwijk +8 more
doaj +1 more source
British Journal of Anaesthesia, 1979 The complement system (C) is composed of group of plasma proteins which under certain conditions react with each other sequentially, resulting in the formation of highly specialized proteases. By their action multimolecular complexes are assembled, and when these events occur on the surface of some cells, the membrane function is impaired and the cell ...
openaire +3 more sources
Frontiers in Immunology, 2023 Primary complement system (C) deficiencies are rare but notably associated with an increased risk of infections, autoimmunity, or immune disorders.
Andrea Balduit +13 more
doaj +1 more source
The complement system in glioblastoma multiforme
Acta Neuropathologica Communications, 2018 The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute.
T. A. M. Bouwens van der Vlis +6 more
doaj +1 more source
The Complement System and Preeclampsia [PDF]
Current Hypertension Reports, 2017 Preeclampsia affects 3-4% of pregnancies with few treatment options to reduce maternal and fetal harm. Recent evidence that targeting the complement system may be an effective therapeutic strategy in prevention or treatment of preeclampsia will be reviewed.Studies in humans confirm the safety and efficacy of C5 blockade in complement-mediated disorders
Jean F, Regal +2 more
openaire +2 more sources