Results 21 to 30 of about 1,857,462 (287)
Francisella tularensis Confronts the Complement System
Frontiers in Cellular and Infection Microbiology, 2017 Francisella tularensis has developed a number of effective evasion strategies to counteract host immune defenses, not the least of which is its ability to interact with the complement system to its own advantage.
Susan R. Brock, Michael J. Parmely
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New insights into the immune functions of podocytes: the role of complement
Molecular and Cellular Pediatrics, 2023 Podocytes are differentiated epithelial cells which play an essential role to ensure a normal function of the glomerular filtration barrier (GFB). In addition to their adhesive properties in maintaining the integrity of the filtration barrier, they have ...
Valentina Bruno +3 more
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Acidosis activates complement system in vitro
Mediators of Inflammation, 1998 We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12)
Michael Emeis +5 more
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Frontiers in Immunology, 2018 The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases.
József Dobó +2 more
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Combined anti-C1-INH and radiotherapy against glioblastoma
BMC Cancer, 2023 Background A more effective immune response against glioblastoma is needed in order to achieve better tumor control. Radiotherapy can induce anti-tumor mediated immune reactions, in addition to its dose response effects.
Emma Liljedahl +7 more
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An update on the role of complement in hepatocellular carcinoma
Frontiers in Immunology, 2022 As a main producer of complement, the environment in the liver is greatly affected by the complement system. Although the complement system is considered to have the ability of nonself discrimination, remarkable studies have revealed the tight ...
Zhijie Xiao +3 more
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British Journal of Anaesthesia, 1979 The complement system (C) is composed of group of plasma proteins which under certain conditions react with each other sequentially, resulting in the formation of highly specialized proteases. By their action multimolecular complexes are assembled, and when these events occur on the surface of some cells, the membrane function is impaired and the cell ...
openaire +3 more sources
The complement system in glioblastoma multiforme
Acta Neuropathologica Communications, 2018 The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute.
T. A. M. Bouwens van der Vlis +6 more
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Pitfalls in complement analysis: A systematic literature review of assessing complement activation
Frontiers in Immunology, 2022 BackgroundThe complement system is an essential component of our innate defense and plays a vital role in the pathogenesis of many diseases. Assessment of complement activation is critical in monitoring both disease progression and response to therapy ...
Ricardo J. M. G. E. Brandwijk +8 more
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Frontiers in Immunology, 2023 Primary complement system (C) deficiencies are rare but notably associated with an increased risk of infections, autoimmunity, or immune disorders.
Andrea Balduit +13 more
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