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Diagnosis of complement alternative pathway disorders [PDF]
Kidney International, 2016 Kidney diseases resulting from abnormal control of the complement alternative pathway include atypical hemolytic uremic syndrome, C3 glomerulonephritis, and dense-deposit disease, as well as atypical postinfectious glomerulonephritis. Although clinically diverse, they all result from loss of surface or fluid-phase complement control, caused by acquired
Andrea Angioï +2 more
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Looking back on the alternative complement pathway [PDF]
Immunobiology, 2018 The alternative pathway of complement originated from the Properdin pathway originally described by the Pillemer laboratory in the 1950s. This work generated great controversy and it took several decades for a consensus on its components, its reaction sequence and its functions to emerge.
Peter Lachmann
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The alternative complement pathway revisited [PDF]
Journal of Cellular and Molecular Medicine, 2008 Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
Tom Mollnes
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Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway
Frontiers in Immunology, 2021 The complement system is central to first-line defense against invading pathogens. However, excessive complement activation and/or the loss of complement regulation contributes to the development of autoimmune diseases, systemic inflammation, and ...
Jonathan Barratt +2 more
doaj +3 more sources
DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER
Медицинская иммунология, 2014 . During attacks of familial mediterranean fever (FMF), multiple systemic events are triggered, most of which promote autoinflammatory reactions. A molecular pattern of immune abnormalities in FMF is yet unclear.
G. M. Mkrtchyan +4 more
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Dengue virus and the complement alternative pathway [PDF]
FEBS Letters, 2020 Dengue disease is an inflammatory‐driven pathology, and complement overactivation is linked to disease severity and vascular leakage. Additionally, dysregulation of complement alternative pathway (AP) components has been described, such as upregulation of complement factor D and downregulation of complement factor H (FH), which activate and inhibit the
Jillian Carr
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Frontiers in Immunology, 2018 The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases.
József Dobó +2 more
doaj +3 more sources
Correction: Sez6L2 inhibits complement by facilitating factor I cleavage of C3b and accelerating the decay of C3 convertases [PDF]
Frontiers in ImmunologyWen Q. Qiu +7 more
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Alternative Complement Pathway Inhibition by Lampalizumab
Ophthalmology Science, 2023 Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS +3 more
doaj +1 more source
Complement factor D is linked to platelet activation in human and rodent sepsis
Intensive Care Medicine Experimental, 2021 Background The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear. Materials Wild-type and CFD-deficient mice (n = 91) were
O. Sommerfeld +6 more
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