The Role and Potential Mechanism of Complement Factor D in Fibromyalgia Development [PDF]
Journal of Pain Research, 2023 Xinhuan Lei,1,* Xiaoting Song,1,* Yongyong Fan,1,* Zhen Chen,1 Liwei Zhang1,2 1Department of Orthopedics, Taizhou Hospital of Zhejiang Province, Zhejiang University, Taizhou, Zhejiang, People’s Republic of China; 2Bone Metabolism and ...
Lei X, Song X, Fan Y, Chen Z, Zhang L
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Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway [PDF]
Frontiers in Immunology, 2021 The complement system is central to first-line defense against invading pathogens. However, excessive complement activation and/or the loss of complement regulation contributes to the development of autoimmune diseases, systemic inflammation, and ...
Jonathan Barratt +2 more
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Complement factor D is linked to platelet activation in human and rodent sepsis [PDF]
Intensive Care Medicine Experimental, 2021 Background The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear. Materials Wild-type and CFD-deficient mice (n = 91) were
O. Sommerfeld +6 more
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Role of complement factor D in cardiovascular and metabolic diseases [PDF]
Frontiers in ImmunologyIn the genesis and progression of cardiovascular and metabolic diseases (CVMDs), adipose tissue plays a pivotal and dual role. Complement factor D (CFD, also known as adipsin), which is mainly produced by adipocytes, is the rate-limiting enzyme of the ...
Yingjin Kong +19 more
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Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing [PDF]
Clinical & Translational Immunology, 2021 Objectives Complete deficiency of alternative pathway (AP) complement factors, explained by homozygous mutations, is a well‐known risk factor for invasive bacterial infections; however, this is less obvious for heterozygous mutations.
Jeroen D Langereis +10 more
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Quantification of the zymogenicity and the substrate-induced activity enhancement of complement factor D [PDF]
Frontiers in Immunology, 2023 Complement factor D (FD) is a serine protease present predominantly in the active form in circulation. It is synthesized as a zymogen (pro-FD), but it is continuously converted to FD by circulating active MASP-3.
Ráhel Dani +8 more
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The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves' Orbitopathy. [PDF]
Invest Ophthalmol Vis Sci, 2023 Graves' orbitopathy (GO) is an orbital manifestation of autoimmune Graves' disease, and orbital fibroblast is considered a target cell, producing pro-inflammatory cytokines and/or differentiating into adipocytes. Adipose tissue has been focused on as an endocrine and inflammatory organ secreting adipokines.
Byeon HJ +6 more
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Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria [PDF]
Haematologica, 2020 Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the absence of complement regulators CD55 and CD59 on affected erythrocytes.
Antonio M. Risitano +8 more
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Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D [PDF]
iScience, 2023 Summary: Patients with HNF1A variants may develop liver steatosis, while the underlying mechanism is still unclear. Here, we established a mouse model carrying the dominant-negative HNF1α P291fsinsC mutation (hHNF1Amut/-) and found that the mutant mice ...
Moke Liu +11 more
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The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure [PDF]
Nature Communications, 2022 Right ventricular (RV) failure is clinically crucial, but there is no specific therapy. Here, the authors show that the complement alternative pathway is activated in RV failure and that blockade of the pathway ameliorates RV failure in mice.
Shogo Ito +34 more
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