Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway [PDF]
Frontiers in Immunology, 2021 The complement system is central to first-line defense against invading pathogens. However, excessive complement activation and/or the loss of complement regulation contributes to the development of autoimmune diseases, systemic inflammation, and ...
Jonathan Barratt +2 more
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Novel Insights into Factor D Inhibition. [PDF]
Int J Mol Sci, 2022 Complement-mediated diseases or complementopathies, such as Paroxysmal nocturnal hemoglobinuria (PNH), cold agglutinin disease (CAD), and transplant-associated thrombotic microangiopathy (TA-TMA), demand advanced complement diagnostics and therapeutics be adopted in a vast field of medical specialties, such as hematology, transplantation, rheumatology,
Gavriilaki E +2 more
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Role of complement factor D in cardiovascular and metabolic diseases [PDF]
Frontiers in ImmunologyIn the genesis and progression of cardiovascular and metabolic diseases (CVMDs), adipose tissue plays a pivotal and dual role. Complement factor D (CFD, also known as adipsin), which is mainly produced by adipocytes, is the rate-limiting enzyme of the ...
Yingjin Kong +19 more
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The Role and Potential Mechanism of Complement Factor D in Fibromyalgia Development [PDF]
Journal of Pain Research, 2023 Xinhuan Lei,1,* Xiaoting Song,1,* Yongyong Fan,1,* Zhen Chen,1 Liwei Zhang1,2 1Department of Orthopedics, Taizhou Hospital of Zhejiang Province, Zhejiang University, Taizhou, Zhejiang, People’s Republic of China; 2Bone Metabolism and ...
Lei X, Song X, Fan Y, Chen Z, Zhang L
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Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria [PDF]
Haematologica, 2020 Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the absence of complement regulators CD55 and CD59 on affected erythrocytes.
Antonio M. Risitano +8 more
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Beyond the p factor: Is there a d factor? [PDF]
JCPP Advances, 2021 Samuele Cortese +3 more
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HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse [PDF]
Scientific Reports, 2020 Excessive intake of fat causes accumulation of fat in liver, leading to non-alcoholic fatty liver disease (NAFLD). High-fat diet (HFD) upregulates the expression of Factor D, a complement pathway component, in the liver of mice. However, the functions of
Hiromi Tsuru +3 more
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Psychodynamic Psychotherapy for Functional (Psychogenic) Movement Disorders [PDF]
Journal of Movement Disorders, 2017 Objective As the literature for the treatment of functional (psychogenic) movement disorders (FMD) is sparse, we assessed clinical outcomes in patients with FMD who underwent treatment with psychodynamic psychotherapy (PDP).
Vibhash D. Sharma +2 more
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Is Hypovitaminosis D a Risk Factor for Heart Failure?
Life, 2023 Background: Several studies in recent years have shown the association between vitamin D levels and heart failure. Vitamin D deficiency is related to increased cardiovascular morbidity and mortality, with a higher risk of developing heart failure.
Asmaa Carla Hagău +3 more
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Investigating the relationship between hypertension and regular consumption of vitamin D [PDF]
Reviews in Clinical Medicine, 2020 Introduction: Hypertension (HTN) is one of the most life-threatening disorders worldwide. Although some examinations have demonstrated an incidental relationship between blood pressure and serum level of 25-hydroxyvitamin D, there have been new exchanges
Nasrin Milani +3 more
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