Results 21 to 30 of about 392,488 (288)

Small-molecule factor D inhibitors targeting the alternative complement pathway [PDF]

Nature Chemical Biology, 2016
Complement is a key component of the innate immune system, recognizing pathogens and promoting their elimination. Complement component 3 (C3) is the central component of the system. Activation of C3 can be initiated by three distinct routes-the classical, the lectin and the alternative pathways-with the alternative pathway also acting as an ...
Maibaum, Jürgen, Liao, Sha Mei, Vulpetti, Anna, Ostermann, Nils, Randl, Stefan, Rüdisser, Simon, Lorthiois, Edwige, Erbel, Paul, Kinzel, Bernd, Kolb, Fabrice A, Barbieri, Samuel, Wagner, Julia, Durand, Corinne, Fettis, Kamal, Dussauge, Solene, Hughes, Nicola, Delgado, Omar, Hommel, Ulrich, Gould, Ty, Sweeney, Aengus Mac, Gerhartz, Bernd, Cumin, Frederic, Flohr, Stefanie, Schubart, Anna, Jaffee, Bruce, Harrison, Richard, RISITANO, ANTONIO MARIA, Eder, Jörg, Anderson, Karen   +28 more
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The Effect of Eight Weeks Aerobic Training and Omega3 Ingestion on the Levels of Adipsin and Insulin Resistance in Overweight and Obese Women [PDF]

Women’s Health Bulletin, 2021
Background: Exercise training and omega-3 supplementation are believed to have a positive effect on obese and overweight people. We conducted the present study in order to investigate the effect of aerobic training and omega3 ingestion on the levels of ...
Saleheh Ahmadzadeh, Mandana Gholami, Shahram Soheili, Farshad Ghazalian   +3 more
doaj   +1 more source

Adipsin – summing up large-scale results: A review

Consilium Medicum, 2022
Adipsin is one of the first discovered adipokines hormones produced by adipose tissue. Adipsin performs the function of a regulator of carbohydrate and lipid metabolism and participates in the adaptation of metabolism to the real needs of the body ...
Vladimir V. Salukhov, Yaroslav R. Lopatin, Alexey A. Minakov   +2 more
doaj   +1 more source

A family with complement factor D deficiency [PDF]

Journal of Clinical Investigation, 2001
A complement factor D deficiency was found in a young woman who had experienced a serious Neisseria meningitidis infection, in a deceased family member with a history of meningitis, and in three relatives without a history of serious infections. The patient and these three relatives showed a normal activity of the classical complement pathway, but a ...
Biesma, D.H., Hannema, A.J., van Velzen-Blad, H., Mulder, L., van Zwieten, R., Kluijt, I., Roos, D.   +6 more
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Systemic complement activation in age-related macular degeneration. [PDF]

PLoS ONE, 2008
Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly. To further test the hypothesis that defective control of
Hendrik P N Scholl, Peter Charbel Issa, Maja Walier, Stefanie Janzer, Beatrix Pollok-Kopp, Florian Börncke, Lars G Fritsche, Ngaihang V Chong, Rolf Fimmers, Thomas Wienker, Frank G Holz, Bernhard H F Weber, Martin Oppermann   +12 more
doaj   +1 more source

Complement factor D, a novel serine protease [PDF]

Protein Science, 1996
AbstractFactor D is unique among serine proteases in that it requires neither enzymatic cleavage for expression of proteolytic activity nor inactivation by a serpin for its control. Regulation of factor D activity is instead attained by a novel mechanism that depends on reversible conformational changes for expression and control of catalytic activity.
J E, Volanakis, S V, Narayana
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Complement activation in factor D-deficient mice [PDF]

Proceedings of the National Academy of Sciences, 2001
To assess the contribution of the alternative pathway in complement activation and host defense and its possible role in the regulation of systemic energy balancein vivo, factor D-deficient mice were generated by gene targeting. The mutant mice have no apparent abnormality in development and their body weights are similar to those of factor D ...
Y, Xu, M, Ma, G C, Ippolito, H W, Schroeder, M C, Carroll, J E, Volanakis   +5 more
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Platelet-Derived Growth Factor-D Activates Complement System to Propagate Macrophage Polarization and Neovascularization

Frontiers in Cell and Developmental Biology, 2021
Platelet-derived growth factor-D (PDGF-D) is highly expressed in immune cells. However, the potential role of PDGF-D in immune system remains thus far unclear.
Zhen Xiong, Qianqian Wang, Wanhong Li, Lijuan Huang, Jianing Zhang, Juanhua Zhu, Bingbing Xie, Shasha Wang, Haiqing Kuang, Xianchai Lin, Chunsik Lee, Anil Kumar, Xuri Li   +12 more
doaj   +1 more source

Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients

Cells, 2023
Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler, Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin   +3 more
doaj   +1 more source

Quantification of the pro-form of human complement component factor D (adipsin) [PDF]

Journal of Immunological Methods, 2022
Factor D (also known as adipsin) is a serine protease and part of the complement system, involved in innate immune responses and effector functions of antibodies. Factor D cleaves factor B complexed with C3b, leading to the C3 convertase C3bBb. This C3 convertase is central in the alternative activation pathway and the amplification loop, which ...
Henriksen, Maiken Lumby, Nielsen, Christian, Pedersen, Dennis, Andersen, Gregers Rom; id_orcid 0000-0001-6292-3319, Thiel, Steffen; id_orcid 0000-0002-4817-155X, Palarasah, Yaseelan, Hansen, Soren Werner Karlskov   +6 more
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