Results 1 to 10 of about 2,166,159 (300)

In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients. [PDF]

Sci Rep
Kiszel P, Miklós J, Kajdácsi E, Sinkovits G, Cervenak L, Prohászka Z.   +5 more
europepmc   +1 more source

IgM Anti-Ganglioside Binding and Complement Activation in an iPSC-Derived Motor Neuron Model for Multifocal Motor Neuropathy. [PDF]

Neurol Neuroimmunol Neuroinflamm
Krijgsman D, Dijkxhoorn K, de Zeeuw E, Bloemenkamp LM, Bos JW, van Eijk RPA, Van de Walle I, Huizinga R, Jacobs BC, Leusen JHW, Pasterkamp RJ, Hack CE, Budding K, van der Pol WL.   +13 more
europepmc   +1 more source

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease. [PDF]

Am J Hematol
Allali S, Sbeih N, Rignault-Bricard R, Bruce J, Gall ML, Heilbronner C, de Cacqueray N, Angyalosy S, Taylor M, Brice J, de Montalembert M, Bevacqua M, Gautier EF, Hermine O, Maciel TT.   +14 more
europepmc   +1 more source

Complement activation

Immunology Today, 1981
When activated, the system of serum proteins known as complement is involved in a wide variety of responses to inflammatory and noxious stimuli. In this article Eric Brown and Michael Frank review the activation of complement by the classical and alternative pathways and discuss some of its biological effects.
E J, Brown, M M, Frank
openaire   +2 more sources

Initiation of Complement Activation

Springer Seminars in Immunopathology, 1984
The complement system is an excellent one to look at as an example of a triggered enzyme system. It is found to use almost all the strategies of enzyme cascades and for initiation which were discussed in the introduction. The classical pathway is a fine example of an active zymogen form of activation and the alternative pathway is the canonical example
P J, Lachmann, N C, Hughes-Jones
openaire   +2 more sources

Bispecific Complement Engagers for Targeted Complement Activation

The Journal of Immunology, 2023
Abstract Activation of the complement system represents an important effector mechanism of endogenous and therapeutic Abs. However, efficient complement activation is restricted to a subset of Abs due to the requirement of multivalent interactions between the Ab Fc regions and the C1 complex.
Dennis V Pedersen, Heidi Gytz, Mikael B L Winkler, Alessandra Zarantonello, Niklas Baumann, Annette G Hansen, Steffen Thiel, Gregers R Andersen, Thomas Valerius, Nick S Laursen   +9 more
openaire   +3 more sources

Complement activation in psoriasis

Clinical and Experimental Dermatology, 1990
Plasma from 16 patients with psoriasis and 12 healthy control subjects were measured for iC3b, C4d, and Bb fragments generated by complement activation. Plasma concentrations for iC3b, C4d, and Bb fragments were found to be significantly increased in the patients with psoriasis.
E W, Rosenberg, P W, Noah, R J, Wyatt, R M, Jones, W P, Kolb   +4 more
openaire   +2 more sources

Complement activation and atherosclerosis

Molecular Immunology, 1999
Atherosclerosis is an inflammatory disease mediated through the action of monocyte/macrophages, complement and T-lymphocytes. C5a and monocyte chemotactic factor released during complement activation in the arterial wall may participate in the initial monocyte recruitment. Assembly of C5b-9 on cells of the arterial wall may also induce cell lysis.
F, Niculescu, H, Rus
openaire   +2 more sources

Activity of Mouse Complement

The Journal of Immunology, 1962
Summary A test has been devised to measure hemolytic complement activity of mouse serum. The chief requirement for detecting mouse hemolytic complement is the use of extremely large amounts of sensitizing antibody. The hemolytic factor measured in mouse serum is indeed complement.
Rosenberg, L T, Tachibana, D K
openaire   +2 more sources