Soluble Membrane Attack Complex: Biochemistry and Immunobiology [PDF]
Frontiers in Immunology, 2020 The soluble membrane attack complex (sMAC, a.k.a., sC5b-9 or TCC) is generated on activation of complement and contains the complement proteins C5b, C6, C7, C8, C9 together with the regulatory proteins clusterin and/or vitronectin.
Scott R. Barnum +2 more
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In vitro Measurement of Membrane Attack Complex in RPE Cells [PDF]
Bio-Protocol, 2021 Initiation of the complement system results in the formation of a multiprotein pore termed the membrane attack complex (MAC, C5b-C9). MAC pores accumulate on a cell surface and can result in cell lysis.
Kelly Mulfaul, Sarah Doyle
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Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys [PDF]
Frontiers in Immunology, 2021 The membrane attack complex—also known as C5b-9—is the end-product of the classical, lectin, and alternative complement pathways. It is thought to play an important role in the pathogenesis of various kidney diseases by causing cellular injury and tissue
Jacob J. E. Koopman +5 more
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Structural basis for membrane attack complex inhibition by CD59 [PDF]
Nature Communications, 2023 CD59 protects human cells from damage by the MAC immune pore. The authors show how CD59 inhibits MAC, by deflecting pore-forming β-hairpins of complement proteins.
Emma C. Couves +6 more
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The mystery behind membrane insertion: a review of the complement membrane attack complex. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2017 The membrane attack complex (MAC) is an important innate immune effector of the complement terminal pathway that forms cytotoxic pores on the surface of microbes. Despite many years of research, MAC structure and mechanism of action have remained elusive, relying heavily on modelling and inference from biochemical experiments.
Bayly-Jones C, Bubeck D, Dunstone MA.
europepmc +6 more sources
Structural basis of soluble membrane attack complex packaging for clearance [PDF]
Nature Communications, 2021 To prevent unregulated complement activation, extracellular chaperones capture soluble precursors to the membrane attack complex (sMAC). Here, structural analysis of sMAC reveals how clusterin recognizes heterogeneous sMAC complexes and inhibits ...
Anaïs Menny +5 more
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Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration [PDF]
Cells, 2022 Recessive Stargardt disease (STGD1) is an inherited retinopathy caused by mutations in the ABCA4 gene. The ABCA4 protein is a phospholipid-retinoid flippase in the outer segments of photoreceptors and the internal membranes of retinal pigment epithelial (
Eunice Sze Yin Ng +8 more
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The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9 [PDF]
Communications Biology, 2023 The cryo-EM structure of monoclonal antibody aE11 bound to polyC9 reveals that the binding site within the Membrane Attack Complex is a quaternary discontinuous epitope formed by two separate surfaces of the oligomeric C9 periphery.
Charles Bayly-Jones +11 more
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Quantitative Analysis of Complement Membrane Attack Complex Proteins Associated with Extracellular Vesicles [PDF]
ProteomesExtracellular vesicles (EVs) represent a universal mechanism of intercellular communication in normal and pathological conditions. There are reports showing the presence of complement proteins in EV preparations, specifically those that can form a ...
Illarion V. Turko
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Membrane Attack Complex C5b-9 Promotes Renal Tubular Epithelial Cell Pyroptosis in Trichloroethylene-Sensitized Mice [PDF]
Frontiers in Pharmacology, 2022 Trichloroethylene (TCE), a commonly used organic solvent, is known to cause trichloroethylene hypersensitivity syndrome (THS), also called occupational medicamentosa–like dermatitis due to TCE (OMDT) in China.
Feng Wang +8 more
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