An Ancient Molecular Arms Race: Chlamydia vs. Membrane Attack Complex/Perforin (MACPF) Domain Proteins [PDF]
Frontiers in Immunology, 2020 Dynamic interactions that govern the balance between host and pathogen determine the outcome of infection and are shaped by evolutionary pressures. Eukaryotic hosts have evolved elaborate and formidable defense mechanisms that provide the basis for ...
Gabrielle Keb, Kenneth A. Fields
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Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System [PDF]
Frontiers in Immunology, 2020 The complement system has developed different strategies to clear infections by several effector mechanisms, such as opsonization, which supports phagocytosis, attracting immune cells by C3 and C5 cleavage products, or direct killing of pathogens by the ...
Zahra Malekshahi +5 more
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Bacterial killing by complement requires direct anchoring of membrane attack complex precursor C5b-7. [PDF]
PLoS Pathogens, 2020 An important effector function of the human complement system is to directly kill Gram-negative bacteria via Membrane Attack Complex (MAC) pores. MAC pores are assembled when surface-bound convertase enzymes convert C5 into C5b, which together with C6 ...
Dennis J Doorduijn +7 more
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Membrane Attack Complex in Myocardial Ischemia/Reperfusion Injury: A Systematic Review for Post Mortem Applications [PDF]
Diagnostics, 2020 The complement system has a significant role in myocardial ischemia/reperfusion injury, being responsible for cell lysis and amplification of inflammatory response.
Cristina Mondello +6 more
doaj +2 more sources
Complement Membrane Attack Complex: New Roles, Mechanisms of Action, and Therapeutic Targets. [PDF]
Am J Pathol, 2020 The complement membrane attack complex (MAC) is classically known as a cytolytic effector of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or targeted cells, leading to osmolysis. Nucleated cells resist MAC-mediated cytolysis by expression of inhibitors that block MAC assembly or by rapid removal of MAC through ...
Xie CB, Jane-Wit D, Pober JS.
europepmc +4 more sources
The Membrane Attack Complex/Perforin Superfamily. [PDF]
J Mol Microbiol Biotechnol, 2017 The membrane attack complex/perforin (MACPF) superfamily consists of a diverse group of proteins involved in bacterial pathogenesis and sporulation as well as eukaryotic immunity, embryonic development, neural migration and fruiting body formation.
Moreno-Hagelsieb G +3 more
europepmc +6 more sources
A Case of Neisseria sicca Bacteremia Due to Eculizumab Therapy
Annals of Internal Medicine: Clinical Cases, 2023 Eculizumab is a monoclonal antibody indicated for the treatment of complement-mediated disorders. Despite its utility, eculizumab increases risk for infection with Neisseria species, owing to membrane attack complex inhibition.
Kelly A. Russo, Ted Louie
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Bacterial killing by complement requires membrane attack complex formation via surface‐bound C5 convertases [PDF]
EMBO Journal, 2019 Bart Bardoel +2 more
exaly +2 more sources
Structural basis for membrane attack complex inhibition by CD59
Nature Communications, 2022 Abstract CD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement proteins C8 and C9 at the membrane to prevent insertion and polymerization of membrane attack complex (MAC) pores. We present cryoelectron microscopy structures of two
Couves EC +6 more
europepmc +6 more sources
Frontiers in Immunology, 2022 Gram-negative bacteria from the genus Acinetobacter are responsible for life-threating hospital-related infections such as pneumonia, septicemia, and meningitis, especially in immunocompromised patients.
Michal Magda +6 more
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