Reduced membrane attack complex formation in umbilical cord blood during Eculizumab treatment of the mother: a case report [PDF]
BMC Nephrology, 2019 Background Atypical hemolytic uremic syndrome (aHUS) is a disorder of the microvasculature with hemolytic anemia, thrombocytopenia and acute kidney injury.
Subagini Nagarajah +7 more
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An Ancient Molecular Arms Race: Chlamydia vs. Membrane Attack Complex/Perforin (MACPF) Domain Proteins [PDF]
Frontiers in Immunology, 2020 Dynamic interactions that govern the balance between host and pathogen determine the outcome of infection and are shaped by evolutionary pressures. Eukaryotic hosts have evolved elaborate and formidable defense mechanisms that provide the basis for ...
Gabrielle Keb, Kenneth A. Fields
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Bacterial killing by complement requires direct anchoring of membrane attack complex precursor C5b-7. [PDF]
PLoS Pathogens, 2020 An important effector function of the human complement system is to directly kill Gram-negative bacteria via Membrane Attack Complex (MAC) pores. MAC pores are assembled when surface-bound convertase enzymes convert C5 into C5b, which together with C6 ...
Dennis J Doorduijn +7 more
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Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System [PDF]
Frontiers in Immunology, 2020 The complement system has developed different strategies to clear infections by several effector mechanisms, such as opsonization, which supports phagocytosis, attracting immune cells by C3 and C5 cleavage products, or direct killing of pathogens by the ...
Zahra Malekshahi +5 more
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Membrane Attack Complex in Myocardial Ischemia/Reperfusion Injury: A Systematic Review for Post Mortem Applications [PDF]
Diagnostics, 2020 The complement system has a significant role in myocardial ischemia/reperfusion injury, being responsible for cell lysis and amplification of inflammatory response.
Cristina Mondello +6 more
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Complement Membrane Attack Complex: New Roles, Mechanisms of Action, and Therapeutic Targets. [PDF]
Am J Pathol, 2020 Xie CB, Jane-Wit D, Pober JS.
europepmc +3 more sources
The membrane attack complex as an inflammatory trigger
Immunobiology, 2016 The final common pathway of all routes of complement activation involves the non-enzymatic assembly of a complex comprising newly formed C5b with the plasma proteins C6, C7, C8 and C9. When assembly occurs on a target cell membrane the forming complex inserts into and through the bilayer to create a pore, the membrane attack complex (MAC).
B Paul Morgan
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A Case of Neisseria sicca Bacteremia Due to Eculizumab Therapy
Annals of Internal Medicine: Clinical Cases, 2023 Eculizumab is a monoclonal antibody indicated for the treatment of complement-mediated disorders. Despite its utility, eculizumab increases risk for infection with Neisseria species, owing to membrane attack complex inhibition.
Kelly A. Russo, Ted Louie
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Frontiers in Immunology, 2022 Gram-negative bacteria from the genus Acinetobacter are responsible for life-threating hospital-related infections such as pneumonia, septicemia, and meningitis, especially in immunocompromised patients.
Michal Magda +6 more
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Cells, 2020 We have previously shown that blood astrocytic-origin extracellular vesicles (AEVs) from Alzheimer’s disease (AD) patients contain high complement levels.
Carlos J. Nogueras-Ortiz +9 more
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