Results 11 to 20 of about 116,413 (235)

Bactericidal membrane attack complex formation initiates at the new pole of E. coli [PDF]

EMBO Reports
Human immune protection against bacteria critically depends on activation of the complement system. The direct bacteriolytic activity of complement molecules against Gram-negative bacteria acts via the formation of Membrane Attack Complex (MAC) pores ...
Marije F L van ‘t Wout, Fabian Hauser, Philippa I P Holzapfel, Bart W Bardoel, Carla J C de Haas, Jaroslaw Jacak, Suzan H M Rooijakkers, Dani A C Heesterbeek   +7 more
doaj   +2 more sources

Design of miniprotein inhibitors targeting complement C9 to block membrane attack complex assembly [PDF]

Nature Communications
The abnormal formation of the membrane attack complex (MAC) is intrinsically linked to a range of acute and chronic immune diseases. The insertion of complement C9 into the membrane is the final step and kinetic bottleneck of MAC formation.
Min Li, Ningning Wang, Xiaoyan Fu, Gege Wei, Ze Zhang, Yanghan Yu, Tianshui Xue, Yifei Zhao, Jinheng Pan, Dongfeng Wang, Meifang Liu, Yong Li, Jinbao Tang, Longxing Cao, Zhaocheng Jian, Shujuan Liang, Bowen Yu   +16 more
doaj   +2 more sources

Single-molecule kinetics of pore assembly by the membrane attack complex [PDF]

Nature Communications, 2019
The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. Here, the authors use atomic force microscopy to show that MAC proteins oligomerize within the membrane, allowing them to ...
Edward S. Parsons, George J. Stanley, Alice L. B. Pyne, Adrian W. Hodel, Adrian P. Nievergelt, Anaïs Menny, Alexander R. Yon, Ashlea Rowley, Ralf P. Richter, Georg E. Fantner, Doryen Bubeck, Bart W. Hoogenboom   +11 more
doaj   +2 more sources

CD59 Protects Primary Human Cerebrovascular Smooth Muscle Cells from Cytolytic Membrane Attack Complex [PDF]

Brain Sciences
Cerebral amyloid angiopathy is characterized by a weakening of the small- and medium-sized cerebral arteries, as their smooth muscle cells are progressively replaced with acellular amyloid β, increasing vessel fragility and vulnerability to ...
Carson D. Whinnery, Ying Nie, Danilo S. Boskovic, Salvador Soriano, Wolff M. Kirsch   +4 more
doaj   +2 more sources

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers [PDF]

Nature Communications, 2018
The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to ...
Anaïs Menny, Marina Serna, Courtney M. Boyd, Scott Gardner, Agnel Praveen Joseph, B. Paul Morgan, Maya Topf, Nicholas J. Brooks, Doryen Bubeck   +8 more
doaj   +2 more sources

Structural basis of complement membrane attack complex formation

Nature Communications, 2016
The membrane attack complex (MAC) is an immune effector that kills pathogens by forming pores in their membrane. Here the authors use cryo-electron microscopy to reveal that the full MAC is an asymmetric pore with a split-washer configuration and ...
Marina Serna, Joanna L. Giles, B. Paul Morgan, Doryen Bubeck   +3 more
doaj   +4 more sources

Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes. [PDF]

PLoS Pathogens, 2021
Infections with Gram-negative bacteria form an increasing risk for human health due to antibiotic resistance. Our immune system contains various antimicrobial proteins that can degrade the bacterial cell envelope.
Dani A C Heesterbeek, Remy M Muts, Vincent P van Hensbergen, Pieter de Saint Aulaire, Tom Wennekes, Bart W Bardoel, Nina M van Sorge, Suzan H M Rooijakkers   +7 more
doaj   +2 more sources

The mystery behind membrane insertion: a review of the complement membrane attack complex [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2017
The membrane attack complex (MAC) is an important innate immune effector of the complement terminal pathway that forms cytotoxic pores on the surface of microbes. Despite many years of research, MAC structure and mechanism of action have remained elusive, relying heavily on modelling and inference from biochemical experiments.
Doryen Bubeck, Michelle A Dunstone, Charles Bayly-Jones   +2 more
exaly   +6 more sources

Novel Selection Approaches to Identify Antibodies Targeting Neoepitopes on the C5b6 Intermediate Complex to Inhibit Membrane Attack Complex Formation [PDF]

Antibodies, 2021
The terminal pathway of complement is implicated in the pathology of multiple diseases and its inhibition is, therefore, an attractive therapeutic proposition. The practicalities of inhibiting this pathway, however, are challenging, as highlighted by the
Lasse Stach, Emily K. H. Dinley, Nadia Tournier, Ryan P. Bingham, Darren A. Gormley, Jo L. Bramhall, Adam Taylor, Jane E. Clarkson, Katherine A. Welbeck, Claire L. Harris, Maria Feeney, Jane P. Hughes, Armin Sepp, Thil D. Batuwangala, Semra J. Kitchen, Eva-Maria Nichols   +15 more
doaj   +2 more sources

Reduced membrane attack complex formation in umbilical cord blood during Eculizumab treatment of the mother: a case report [PDF]

BMC Nephrology, 2019
Background Atypical hemolytic uremic syndrome (aHUS) is a disorder of the microvasculature with hemolytic anemia, thrombocytopenia and acute kidney injury.
Subagini Nagarajah, Martin Tepel, Christian Nielsen, Kristian Assing, Yaseelan Palarasah, Lise Lotte Torvin Andersen, Lotte Borg Lange, Claus Bistrup   +7 more
doaj   +2 more sources