Membrane Attack Complex C5b-9 Promotes Renal Tubular Epithelial Cell Pyroptosis in Trichloroethylene-Sensitized Mice [PDF]
Frontiers in Pharmacology, 2022 Trichloroethylene (TCE), a commonly used organic solvent, is known to cause trichloroethylene hypersensitivity syndrome (THS), also called occupational medicamentosa–like dermatitis due to TCE (OMDT) in China.
Feng Wang +8 more
doaj +2 more sources
Structural basis for membrane attack complex inhibition by CD59
Nature Communications, 2022 AbstractCD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement proteins C8 and C9 at the membrane to prevent insertion and polymerization of membrane attack complex (MAC) pores.
Couves EC +6 more
europepmc +9 more sources
Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages [PDF]
Frontiers in Immunology, 2021 Interleukin 1β (IL-1β) plays a major role in inflammation and is secreted by immune cells, such as macrophages, upon recognition of danger signals. Its secretion is regulated by the inflammasome, the assembly of which results in caspase 1 activation ...
Ines Diaz-del-Olmo +8 more
doaj +2 more sources
Bactericidal membrane attack complex formation initiates at the new pole of E. coli [PDF]
EMBO ReportsHuman immune protection against bacteria critically depends on activation of the complement system. The direct bacteriolytic activity of complement molecules against Gram-negative bacteria acts via the formation of Membrane Attack Complex (MAC) pores ...
Marije F L van ‘t Wout +7 more
doaj +2 more sources
The Membrane Attack Complex/Perforin Superfamily. [PDF]
J Mol Microbiol Biotechnol, 2017 The membrane attack complex/perforin (MACPF) superfamily consists of a diverse group of proteins involved in bacterial pathogenesis and sporulation as well as eukaryotic immunity, embryonic development, neural migration and fruiting body formation.
Moreno-Hagelsieb G +3 more
europepmc +6 more sources
Single-molecule kinetics of pore assembly by the membrane attack complex [PDF]
Nature Communications, 2019 The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. Here, the authors use atomic force microscopy to show that MAC proteins oligomerize within the membrane, allowing them to ...
Edward S. Parsons +11 more
doaj +2 more sources
CD59 Protects Primary Human Cerebrovascular Smooth Muscle Cells from Cytolytic Membrane Attack Complex [PDF]
Brain SciencesCerebral amyloid angiopathy is characterized by a weakening of the small- and medium-sized cerebral arteries, as their smooth muscle cells are progressively replaced with acellular amyloid β, increasing vessel fragility and vulnerability to ...
Carson D. Whinnery +4 more
doaj +2 more sources
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers [PDF]
Nature Communications, 2018 The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to ...
Anaïs Menny +8 more
doaj +2 more sources
Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes. [PDF]
PLoS Pathogens, 2021 Infections with Gram-negative bacteria form an increasing risk for human health due to antibiotic resistance. Our immune system contains various antimicrobial proteins that can degrade the bacterial cell envelope.
Dani A C Heesterbeek +7 more
doaj +2 more sources
Novel Selection Approaches to Identify Antibodies Targeting Neoepitopes on the C5b6 Intermediate Complex to Inhibit Membrane Attack Complex Formation [PDF]
Antibodies, 2021 The terminal pathway of complement is implicated in the pathology of multiple diseases and its inhibition is, therefore, an attractive therapeutic proposition. The practicalities of inhibiting this pathway, however, are challenging, as highlighted by the
Lasse Stach +15 more
doaj +2 more sources