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Virus-Encoded Complement Regulators: Current Status

Viruses, 2021
Viruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and ...
Anwesha Sinha, Anup Kumar Singh, Trupti Satish Kadni, Jayati Mullick, Arvind Sahu   +4 more
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Different Complement Activation Pathways Underly Cognitive Impairment and Type 2 Diabetes Mellitus Combined With Cognitive Impairment

Frontiers in Aging Neuroscience, 2022
BackgroundThe immune response and the complement system are associated with cognitive impairment and diabetes mellitus, respectively. Activation of the complement system in these diseases occurs mainly through either the classical pathway or the ...
Zhenxing Li, Weiwei Zhang, Feng Gao, Feng Gao, Qiqiang Tang, Dongmei Kang, Yong Shen, Yong Shen   +7 more
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Interaction Between the Complement System and Infectious Agents – A Potential Mechanistic Link to Neurodegeneration and Dementia

Frontiers in Cellular Neuroscience, 2021
As part of the innate immune system, complement plays a critical role in the elimination of pathogens and mobilization of cellular immune responses. In the central nervous system (CNS), many complement proteins are locally produced and regulate nervous ...
Noriko Shinjyo, Noriko Shinjyo, Wataru Kagaya, Marcela Pekna, Marcela Pekna   +4 more
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Profiling Complement System Components in Primary CNS Vasculitis

Cells, 2021
Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji, Christian W. Keller, Simon Koch, Heinz Wiendl, Christian Gerloff, Tim Magnus, Jan D. Lünemann   +6 more
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Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host

Frontiers in Microbiology, 2019
Parasitic infections induce host immune responses that eliminate the invading parasites. However, parasites have evolved to develop many strategies to evade host immune attacks and survive in a hostile environment. The complement system acts as the first
Shuai Shao, Ximeng Sun, Yi Chen, Bin Zhan, Xinping Zhu   +4 more
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Local Activation of the Alternative Pathway of Complement System in Mycotic Keratitis Patient Tear

Frontiers in Cellular and Infection Microbiology, 2020
Aspergillus flavus and Fusarium solani are the predominant causative agents of mycotic keratitis in the tropical part of the world. Tear proteins play a major role in the innate immune response against these fungal infections as has been shown by the ...
Mohammed Razeeth Shait Mohammed, Sandhya Krishnan, Rabbind Singh Amrathlal, Jeya Maheshwari Jayapal, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Dharmalingam Kuppamuthu   +6 more
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Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity

Frontiers in Immunology, 2022
The complement system is a part of the innate immune system, where it labels intruding pathogens as well as dying host cells for clearance. If complement regulation is compromised, the system may contribute to pathogenesis.
Henrik Pedersen, Rasmus Kjeldsen Jensen, Annette Gudmann Hansen, Steen Vang Petersen, Steffen Thiel, Nick Stub Laursen, Nick Stub Laursen, Gregers Rom Andersen   +7 more
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Implications of Complement Imbalance in COVID-19: A Molecular Mechanistic Discussion on the Importance of Complement Balance [PDF]

Iranian Journal of Immunology, 2023
Two central questions in COVID-19 treatment which should be considered are: “How does the imbalance of the complement system affect the therapeutic approaches?” and “Do we consider complement inhibitors in therapeutic protocols?”.
Mehdi Torabizadeh, Helia Modaresi Asfeh, Zeinab Deris Zayeri, Cerdan Dominique, Hashem Kazemi, Najmaldin Saki   +5 more
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Biosynthetic homeostasis and resilience of the complement system in health and infectious diseaseResearch in context

EBioMedicine, 2019
Background: The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis.
Esther Willems, Wynand Alkema, Jenneke Keizer-Garritsen, Anouk Suppers, Michiel van der Flier, Ria H.L.A. Philipsen, Lambert P. van den Heuvel, Elena Volokhina, Renate G. van der Molen, Jethro A. Herberg, Michael Levin, Victoria J. Wright, Inge M.L. Ahout, Gerben Ferwerda, Marieke Emonts, Navin P. Boeddha, Irene Rivero-Calle, Federico Martinon Torres, Hans J.C.T. Wessels, Ronald de Groot, Alain J. van Gool, Jolein Gloerich, Marien I. de Jonge   +22 more
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Factor H Family Proteins in Complement Evasion of Microorganisms

Frontiers in Immunology, 2017
Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Mihály Józsi
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