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Proteins of the lectin pathway of the complement system activation: immunobiological functions, genetics and involvement in the pathogenesis of human diseases

Инфекция и иммунитет, 2022
The complement system is the most ancient components in the innate immunity, mainly functioning to primarily eliminate bacterial agents intravascularly.
Marina V. Smolnikova, Sergey Yu. Tereshchenko   +1 more
doaj   +1 more source

Complement System and C4d expression in cases of Membranous nephropathy

Brazilian Journal of Nephrology
Introduction: Membranous nephropathy (MN) is one of the major causes of nephrotic syndrome. The complement system plays a key role in the pathophysiology of MN.
Fabiano Bichuette Custódio, Crislaine Aparecida da Silva, Fernanda Rodrigues Helmo, Juliana Reis Machado, Marlene Antônia dos Reis   +4 more
doaj   +1 more source

SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems

Frontiers in Immunology, 2021
Infection with SARS-CoV-2 triggers the simultaneous activation of innate inflammatory pathways including the complement system and the kallikrein-kinin system (KKS) generating in the process potent vasoactive peptides that contribute to severe acute ...
Anne G. Savitt, Anne G. Savitt, Samantha Manimala, Tiara White, Tiara White, Marina Fandaros, Wei Yin, Huiquan Duan, Xin Xu, Brian V. Geisbrecht, David A. Rubenstein, Allen P. Kaplan, Ellinor I. Peerschke, Berhane Ghebrehiwet   +13 more
doaj   +1 more source

Evasion Mechanisms Used by Pathogens to Escape the Lectin Complement Pathway

Frontiers in Microbiology, 2017
The complement system is a crucial defensive network that protects the host against invading pathogens. It is part of the innate immune system and can be initiated via three pathways: the lectin, classical and alternative activation pathway.
Anne Rosbjerg, Ninette Genster, Katrine Pilely, Peter Garred   +3 more
doaj   +1 more source

Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system. [PDF]

Proceedings of the National Academy of Sciences, 1996
Xeroderma pigmentosum (XP) is caused by a defect in nucleotide excision repair. Patients in the complementation group E (XP-E) have the mildest form of the disease and the highest level of residual repair activity. About 20% of the cell strains derived from XP-E patients lack a damaged DNA-binding protein (DDB) activity that binds to ultraviolet ...
A, Kazantsev, D, Mu, A F, Nichols, X, Zhao, S, Linn, A, Sancar   +5 more
openaire   +2 more sources

The Role of Apoptosis Proteins and Complement Components in the Etiopathogenesis of Systemic Lupus Erythematosus [PDF]

Clinics, 2010
Systemic lupus erythematosus is a prototypical autoimmune disease characterized by the deregulation of T and B cells, tissue infiltration by mononuclear cells, tissue damage and the production of autoantibodies. There is a consensus that accelerated apoptosis of circulating lymphocytes and/or impaired clearance of apoptotic bodies may increase the ...
Liphaus, Bernadete L., Kiss, Maria Helena Bittencourt   +1 more
openaire   +5 more sources

Measuring Total Classical Pathway and Activities of Individual Components of the Mouse Complement Pathway

Bio-Protocol, 2021
The complement system is a central component of innate immunity, responsible for recognition and killing of bacteria by tagging invaders through opsonisation, thereby promoting phagocytosis, and by direct lysis.
Wioleta Zelek
doaj   +1 more source

Ancient origins: complement in invertebrates [PDF]

Invertebrate Survival Journal, 2005
Proteins with obvious similarities to mammalian complement are widely distributed in the animal kingdom.In the vertebrate lineage, deuterostomes like sea urchins and tunicates express proteins that arehomologues of C3, the central component of the ...
SV Nair, A Ramsden, DA Raftos
doaj   +2 more sources

A new perspective on the pathophysiology of kidney diseases: the intracellular complement system- “complosome”

Frontiers in Nephrology
The complement cascade is a vital component of the innate immune system. It consists of around 50 proteins, including circulating complement proteins and membrane-bound receptors. It operates through three main activation pathways: classical, lectin, and
Emre Leventoğlu, Sevcan A. Bakkaloğlu
doaj   +1 more source

Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities

Frontiers in Immunology, 2018
The complement system is a tightly regulated network of proteins involved in defense against pathogens, inflammatory processes, and coordination of the innate and adaptive immune responses.
Cecilie E. Hertz, Rafael Bayarri-Olmos, Nikolaj Kirketerp-Møller, Sander van Putten, Katrine Pilely, Mikkel-Ole Skjoedt, Peter Garred   +6 more
doaj   +1 more source